Extractions: Question Topics Click on a category below to read questions and answers previously posted, or search the archives by keyword: Help support this website: Donate to Ask the Geneticist ... Reload Page Autoimmune Disorders and Ankylosing spondylitis Last Updated Question My wife suspects she has Ankylosing Spondylitis based on symptomology and positive HLAb27 blood work. We are told that there may be two other genetic markers that can lead to a more definitive diagnosis. Do you know what those markers are and how they are determined? Thank you so much! Answer http://www.spondylitis.org/about/as.aspx. We will review the genetics here and highly recommend that your wife be evaluated by a rheumatologist who can determine the appropriate testing for her. Most autoimmune disorders are thought to be multifactorial. Multifactorial inheritance means that "many factors" are involved in causing a health problem. The factors are usually both genetic and environmental. A combination of genes from both parents, in addition to unknown environmental factors, produce the trait or condition. Multifactorial traits do recur in families because they are partly caused by genes. The environmental factors are generally thought to trigger an immune response to certain environmental influences such as viral infections or sunlight. Once an autoimmune disease is present in a family, other relatives may be at risk to develop the same autoimmune disease, or a different autoimmune disease. For example, a mother may have rheumatoid arthritis, and one of her siblings may develop lupus. Genes and family history are not the only factors involved in determining who will get an autoimmune disease. In other words, if autoimmune diseases are in your family, it does not automatically mean that all relatives will develop one of these conditions. A positive family history of autoimmune disorders means that there is a genetic predisposition that may increase your risk to develop an autoimmune disease.
Extractions: National Institutes of Health Home About MedlinePlus ... Contact Us Search MedlinePlus A histocompatibility antigen blood test looks at proteins called human leukocyte antigens (HLAs), which are found on the surface of nearly every cell in the human body. HLAs are found in large amounts on the surface of white blood cells. They help the immune system tell the difference between body tissue and foreign substances. Blood is drawn from a vein, usually from the inside of the elbow or the back of the hand. The site is cleaned with germ-killing medicine (antiseptic). The health care provider wraps an elastic band around the upper arm to apply pressure to the area and make the vein swell with blood. Next, the health care provider gently inserts a needle into the vein. The blood collects into an airtight vial or tube attached to the needle. The elastic band is removed from your arm. Once the blood has been collected, the needle is removed, and the puncture site is covered to stop any bleeding.
HLA-B27 Antigen: MedlinePlus Medical Encyclopedia Ankylosing spondylitis; Autoimmune disorders; Bone marrow transplant; Histocompatibility antigen test; Kidney transplant; Reactive arthritis http://www.nlm.nih.gov/medlineplus/ency/article/003551.htm
Extractions: National Institutes of Health Home About MedlinePlus ... Contact Us Search MedlinePlus HLA-B27 is a blood test to look for specific protein found on the surface of white blood cells. The protein is called human leukocyte antigen B27 (HLA-B27). Human leukocyte antigens (HLAs) are proteins that help the body’s immune system tell the difference between its own cells and foreign, harmful substances. See also: Histocompatibility antigen test Blood is drawn from a vein, usually from the inside of the elbow or the back of the hand. The puncture site is cleaned with antiseptic. An elastic band is placed around the upper arm to apply pressure and cause the vein to swell with blood. A needle is inserted into the vein, and the blood is collected in an air-tight vial or a syringe. During the procedure, the band is removed to restore circulation. Once the blood has been collected, the needle is removed, and the puncture site is covered to stop any bleeding. In infants or young children: The area is cleansed with antiseptic and punctured with a sharp needle or a lancet. The blood may be collected in a pipette (small glass tube), on a slide, onto a test strip, or into a small container. A bandage may be applied to the puncture site if there is any bleeding.
Understanding Genetics: Human Health And The Genome Ankylosing spondylitis; Autoimmune diseases. Scientists have also used these tests to identify genes involved in how we look. For example, they identified a gene that partly explains http://www.thetech.org/genetics/news.php?id=74
Tendinitis It may also be seen with certain inflammatory conditions (for example, Reiter's syndrome, ankylosing spondylitis), autoimmune disorders (for example, diabetes mellitus), and some http://www.acupuncture4pain.com/diseases_tendinitis.asp
Extractions: Tendinitis involves inflammation of a tendon, the fibrous cord that attaches muscle to bone. It usually affects only one part of the body at a time, and usually lasts a short time, unless involved tissues are continuously irritated. Typical symptoms are: Tendinitis can occur as a result of injury, overuse, or with aging as the tendon loses elasticity. It can also be seen in systemic diseases such as rheumatoid arthritis or diabetes. It may also be seen with certain inflammatory conditions (for example, Reiter's syndrome, ankylosing spondylitis), autoimmune disorders (for example, diabetes mellitus), and some infections. In traditional Chinese medicine, the tendinitis (or tennis elbow)is seen as problem affecting the
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Extractions: Share Ankylosing Spondylitis: Overview Ankylosing spondylitis is an autoimmune disease which affects collagen structures, specifically the joints between the vertebrae of the spine. The joints and ligaments that normally permit the spine to move become inflamed and stiff. The bones of the spine may grow together, causing the spine to become rigid and inflexible. Other joints such as the hips, shoulders, knees, or ankles also may become involved. Incidence; Risk Factors Symptoms of ankylosing spondylitis appear most frequently in young men between the ages of 16 and 35. It is less common in women, whose symptoms are often milder and more difficult to diagnose. About 5% of ankylosing spondylitis cases begin in childhood; boys are more likely to have it than girls.
Rheumatologic Conditions - National Jewish Health Ankylosing Spondylitis Autoimmune Related Lung Diseases; Gout; Lupus (Systemic Lupus Erythematous) Myositis; Osteoarthritis; Osteoporosis; Polymyalgia Rheumatica http://www.nationaljewish.org/healthinfo/conditions/rheumatologic/index.aspx
Extractions: Dept. of Medicine View full profile A rheumatologic condition is one of many systemic (whole body) inflammatory diseases that may affect the skin, joints, muscles, and internal organs. While the underlying causes of rheumatologic conditions are not entirely understood, we do know that rheumatologic diseases are typically autoimmune in nature. This means that the body's immune system attacks itself. As a result of the immune system dysfunction, widespread inflammation can result. Treatment of these systemic autoimmune diseases often relies on immune-suppressing medications. Rheumatologic conditions include: There are many things you can do to reduce the severity of your symptoms. Learn how you can
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Tendinitis Tendinitis may also accompany some inflammatory conditions (such as Reiter syndrome or ankylosing spondylitis), autoimmune disorders (such as type 1 diabetes), and some infections. http://www.umm.edu/altmed/articles/tendinitis-000163.htm
Extractions: Email this page Print this page Note: The resources listed in this guide are not intended to be fully systematic or complete, nor does inclusion here imply any endorsement or recommendation by The University of Maryland or the Center for Integrative Medicine. The University of Maryland and the Center for Integrative Medicine make no warranties, express or implied, about the value or utility for any purpose of the information and resources contained herein. Center for Integrative Medicine Physicians and Staff Tendinitis is the painful inflammation of a tendon and its ligaments, which attach the tendon to bone. It often results from the stress of repetitive movements. Acute or sudden tendinitis may become chronic or long-lasting if it is not treated. People get tendinitis most often in the shoulder (rotator cuff tendinitis), elbow (tennis elbow or golfer's elbow), wrist and thumb (de Quervain's disease), knee (jumper's knee), ankle (Achilles tendinitis), and hip. Calcific tendinitis, which happens when calcium deposits build up in a joint, often occurs in people who have a chronic disease, such as diabetes. What Causes It?:
B Review Pathology Study Tools. Ankylosing spondylitis autoimmune disease, HLA B27 First group of muscles involved in Duchenne muscular dystrophy? pelvic girdle Vitamin K deficiency http://www.studystack.com/menu-218643
Extractions: Home Medical ... B review pathology addthis_pub = 'studystack'; Description: board review for pathology Category: Chiropractic Created by: Kirra Leigh Guidry Randolph on 2009-03-12 Question Answer Ankylosing spondylitis autoimmune disease, HLA B-27 First group of muscles involved in Duchenne muscular dystrophy? pelvic girdle Vitamin K deficiency bruising and bleeding Reiter's syndrome arthritis, Urthritis, conjunctivitis and skin rash Fissures in articular cartilage and decreased proteoglycan within the matrix osteoarthritis deficiency of vitamin B12 results in this anemia megaloblastic anemia Chronic rheumatoid arthritis and splenomegaly Felty's syndrome Elephantiasis obstruction of draining lymphatics Multiple myeloma malignant plasma cells, Bence Jones protein, M spike
Flashcards About B Review Pathology Ankylosing spondylitis autoimmune disease, HLA B27 First group of muscles involved in Duchenne muscular dystrophy? pelvic girdle Vitamin K deficiency http://www.studystack.com/flashcard-218643
Extractions: Home About FAQs Contact Us ... AllRefer Channels :: Yellow Pages Reference Health Quick Jump ADD/ADHD Allergies Alzheimer's Disease Arthritis Asthma Back Pain Breast Cancer Cancer Colon Cancer Depression Diabetes Gallbladder Disease Heart Attack Hepatitis High Cholesterol HIV/AIDS Hypertension Lung Cancer Menopause Migraines/Headaches Osteoporosis Pneumonia Prostate Cancer SARS Stroke Urinary Tract Infection 1600+ More Conditions Health News Symptoms Guide Special Topics Medical Encyclopedia Related Content Most Popular AIDS Ankylosing spondylitis Autoimmune disorders Cataract ... Vision problems Other Topics Eye pain Eye redness Photophobia Eye The eye is the organ of sight, a nearly spherical hollow globe filled with fluids (humors). The outer layer or tunic (sclera, or white, and cornea) is fibrous and protective. The middle tunic layer (choroid, ciliary body and the iris) is vascular. The innermost layer (the retina) is nervous or sensory. The fluids in the eye are divided by the lens into the vitreous humor (behind the lens) and the aqueous humor (in front of the lens). The lens itself is flexible and suspended by ligaments which allow it to change shape to focus light on the retina, which is composed of sensory neurons.
Extractions: Home About FAQs Contact Us ... AllRefer Channels :: Yellow Pages Reference Health Quick Jump ADD/ADHD Allergies Alzheimer's Disease Arthritis Asthma Back Pain Breast Cancer Cancer Colon Cancer Depression Diabetes Gallbladder Disease Heart Attack Hepatitis High Cholesterol HIV/AIDS Hypertension Lung Cancer Menopause Migraines/Headaches Osteoporosis Pneumonia Prostate Cancer SARS Stroke Urinary Tract Infection 1600+ More Conditions Health News Symptoms Guide Special Topics Medical Encyclopedia Related Content Most Popular AIDS Ankylosing spondylitis Autoimmune disorders Cataract ... Vision problems Other Topics Eye pain Eye redness Photophobia You are here : AllRefer.com Health Uveitis Uveitis Alternate Names Iritis, Pars planitis, Choroiditis, Chorioretinitis, Anterior uveitis, Posterior uveitis Definition Uveitis is swelling and irritation of the uvea , the middle layer of the eye. The uvea provides most of the blood supply to the retina Uveitis can be caused by autoimmune disorders such as rheumatoid arthritis or ankylosing spondylitis , infection, or exposure to toxins. However, in many cases the cause is unknown. The most common form of uveitis is anterior uveitis, which involves inflammation in the front part of the eye. It is often called iritis because it is usually only effects the iris, the colored part of the eye. The inflammation may be associated with autoimmune diseases, but most cases occur in healthy people. The disorder may affect only one eye. It is most common in young and middle-aged people.
Rheumatologic Conditions - National Jewish Health Ankylosing Spondylitis Autoimmune Related Lung Diseases; Gout; Lupus (Systemic Lupus Erythematous) Myositis; Osteoarthritis; Osteoporosis; Polymyalgia Rheumatica http://www.nationaljewish.org/healthinfo/conditions/rheumatologic/
Extractions: Dept. of Medicine View full profile A rheumatologic condition is one of many systemic (whole body) inflammatory diseases that may affect the skin, joints, muscles, and internal organs. While the underlying causes of rheumatologic conditions are not entirely understood, we do know that rheumatologic diseases are typically autoimmune in nature. This means that the body's immune system attacks itself. As a result of the immune system dysfunction, widespread inflammation can result. Treatment of these systemic autoimmune diseases often relies on immune-suppressing medications. Rheumatologic conditions include: There are many things you can do to reduce the severity of your symptoms. Learn how you can
Diabetes-related Causes Of Iritis - WrongDiagnosis.com Ankylosing spondylitis; Autoimmune retinal vasculitis Behcet's disease; Behet's syndrome See full list of possible disease causes of Iritis http://www.wrongdiagnosis.com/symptoms/iritis/diabetes.htm
Thyroid Disease Resource Center News - Index Two Genes May Be Associated With 4 Major Autoimmune Disorders Ankylosing spondylitis, autoimmune thyroid disease, multiple sclerosis, and breast cancer may be associated with genes http://www.medscape.com/index/list_3837_0
Autoimmune Disease: Is There A Cure? « Rue309 Ankylosing Spondylitis Autoimmune Hemolytic Anemia Antiphospholipid syndrome Aplastic Anemia Bursitis Chronic active hepatitis Celiac disease Crohn’s disease http://rue309.wordpress.com/2008/06/26/autoimmune-disease-is-there-a-cure/
