81. Personalized Medicine - Information And Resources Portal for research and clinical news and articles related to personalized medicine. http://www.personalizedmedicine.com

More Articles Videos Related Books News ... Contact Info Personalized Medicine Personalized Medicine: The Background Personalized medicine is an extension of traditional approaches to understanding and treating illness. Since the beginning of the study of medicine, physicians have employed evidence found through observation to make a diagnosis or to prescribe treatment. In the past, this was presumably tailored to each individual, but personalized medicine makes treatment more specific. In the modern conception of personalized medicine, the tools provided to the physician are more precise, probing not just the obvious, such as a tumor on a mammogram or cells under a microscope, but the very molecular makeup of each patient. Looking at the patient on this level helps the physician get a profile of the patient’s genetic distinction, or mapping. By investigating this genetic mapping, medical professionals are then able to profile patients, and use the found information to plan out a course of treatment that is much more in step with the way their body works. Genomic medicine and personalized medicine use genetic information to prevent or treat disease in adults or their children. What Can We Gain from a Genetic Map?

82. The Annals Of Pharmacotherapy Independent, interdisciplinary, peer-reviewed journal dedicated to the advancement of pharmacotherapy. http://www.theannals.com

Earn Pharmacist CE from Unbiased, Expert-Written, Peer-Reviewed Articles on Contemporary Clinical Topics Subscriptions Subscribe/Rates Individual Subscription ... Terms and Conditions Journal Resources Author Information Reviewer Information Editorial Board Acknowledgments ... The Annals Related Resources Continuing Education j Pharm Technol Harvey Whitney Books How to use this site Site Map Contact Us 'Net Tips Help ... Harvey Whitney Books Company publishes The Annals of Pharmacotherapy Current Issue November 2010 For Our Patients SM The Annals Pipeline Archived Issues January 1967 - November 2010 Articles Ahead of Print Updated November 9, 2010 Articles Ahead of Print Highlights: RSS feed Acamprosate Calcium as Augmentation Therapy for Anxiety Disorders Carisoprodol Legal Status and Patterns of Abuse Quick Search advanced Author: (e.g., Smith, JS) Keyword(s): Year: Vol: Page: Stanford University Libraries' assists in the publication of The Annals Online Online ISSN: 1542-6270 Print ISSN: 1060-0280

83. 110INTRO Economic, medical and regulatory issues around antidepressants, esp. paroxetine withdrawal syndrome; public accountability and freedom of information; discussion pages. http://www.socialaudit.org.uk/

The Social Audit website was last updated on 4 April 2008 pharmageddon - a world of sickness created and sustained by exploitation of the fear of disease, indifference to real health needs, dependence on authority, and misplaced trust in the triumph of drug benefits over harm. These are the main themes in Medicines out of Control? Medicines out of Control? The Antidepressant Web (1997 to 2003) (4 April 2008) Contents and site index Users discuss experiences with with antidepressants (1998 to date) What was New? (1997 to 2003) Problem taxonomy and forum - suspended You can reach us via mail@socialaudit.org.uk The Antidepressant Web was last updated on 20 November 2003 . At its heart is a 250K paper you can download This paper and the website built around it develop two interwoven themes: How are medicines used to treat depression? and What can be learned from this about the conduct of the main providers of 'healthcare' - doctors, pharmaceutical companies, and government regulators? There are two main ways in. Please click on one: Contents Page What's New?

84. The Lycaeum An Entheogenic Database Includes a comprehensive listing of various mind altering substances, including their chemical structures and effects (with first person accounts). http://www.lycaeum.org/

85. Elliot Brown Consulting Ltd - Welcome To Elliot Brown Consulting MedDRA training courses, CdRom of courses available, and an online demo of MedDRA MedDicIt training. http://www.ebconsulting.co.uk/

Elliot Brown Consulting Beck House, 55 Elmete Drive, Leeds, LS8 2LA, United Kingdom tel: 44 (0)20 8144 5617 fax: 44 (0)870 112 8196 Elliot Brown Consulting and Ergomed CRO have launched PrimeVigilance, a new pharmacovigilance services company. Founded by two globally respected experts, the newly formed PrimeVigilance Ltd. provides a unique offering in the field of pharmacovigilance, more here... Welcome to Elliot Brown Consulting Elliot Brown Consulting provides a dedicated pharmacovigilance resource for the international pharmaceutical and biologicals industries. Our team of highly experienced pharmaceutical and regulatory affairs consultants and associates can provide expert and cost-effective solutions for: Pharmacovigilance systems and processes Safety evaluation and risk management Regulatory compliance Training (including MedDRA training) Services include support for: Safety surveillance PSURs, Clinical Expert Reports Safety Overviews Signal review, benefit-risk assessment Compliance audits MedDRA® and other terminologies Process review and improvements Risk management strategies Pharmacovigilance Services Our consultants are at the leading edge of developments in pharmacovigilance and therapeutic risk management. Elliot Brown Consulting offers a range of services including:

86. Optimizing A Unimodal Response Function In Phase I/II Clinical Trials Adaptive sampling to locate the best dose. http://www.eecs.umich.edu/~qstout/abs/Design2000.html

Optimizing a Unimodal Response Function for Binary Variables Janis Hardwick Quentin F. Stout University of Michigan Abstract : In some dose response settings in clinical trials, there are completing failure modes where low doses do not elicit a positive response, while overly large doses elicit a toxic response. Typically this occurs in trials known as phase I/II trials. In such settings, often the dose response curve which plots dose vs. success (efficacious and non-toxic), is unimodal, i.e., it is increasing and then decreasing. This then leads to the problem of finding the mode (highest point) of the curve. In this paper, several sampling designs are examined for the problem of optimizing a response function from a set of Bernoulli populations, where the population means are assumed to have a strict unimodal structure. The designs are evaluated both on their efficiency in identifying a good population at the end of the experiment, and in their efficiency in sampling from good populations during the trial. A new design, that adapts multiarm bandit approaches to this unimodal structure, is shown to be superior to the designs previously proposed. These earlier designs were based on Polya urns, stochastic approximation, and up and down rules (random walks, Markov chains). The bandit design utilizes approximate Gittins indices and shape constrained regression to model the dependencies between the arms. Note that our design, and some of the others, are nonparametric, so they are quite flexible and do not make strong assumptions about the shape of the curve.

87. Body Surface Area Calculator Calculates Body Surface Area, with advanced features such as automatic units conversion. The can be used for medication dose calculations. http://www.halls.md/body-surface-area/bsa.htm

88. PsychopharmINFO Daily and monthly updates of Medline research articles about psychiatric medications, mostly antidepressants. http://www.psychopharminfo.com

89. Psychiatric Medications - HealthyPlace APA article and resources regarding psychiatric medications. http://www.healthyplace.com/site/psychiatric_medications.htm

90. Psychiatric Drug Facts With Dr. Peter Breggin - HOME Peter R. Breggin, M.D., presents his views about the potential dangers of SSRIs, psychostimulants, benzodiazepines, antipsychotic drugs, electroshock, and other treatments. Books available for sale. http://www.breggin.com/

91. Crazy Meds - Mental Illness With An Attitude A guide to psychiatric medications from first-hand experience, anecdotal evidence and personal research. http://www.crazymeds.us/

92. Personalized Medicine (Pharmacogenetics) Provides an easily understandable introduction to pharmacogenomics, the study of how different drugs interact with multiple genes and the biological molecules they encode. http://learn.genetics.utah.edu/units/pharma/phwhatis/

About Us Feedback HOME PERSONALIZED MEDICINE (PHARMACOGENOMICS) PERSONALIZED MEDICINE (PHARMACOGENOMICS) Why do people vary in their responses to prescribed medications, both with respect to how well it works and adverse reactions to it? Researchers think the answer lies in our genes. Scientists, physicians and the pharmaceutical industry are actively developing ways to customize medical treatments to suit our unique genetic signatures. The study of how genetic variations interface with drug response and disease risk is called pharmacogenomics. interactive explore YOUR DOCTOR'S NEW GENETIC TOOLS Investigate a pharmacogenetic test that is being used in the clinic today. learn more MAKING SNPs MAKE SENSE See how tiny variations in a person's DNA make-up can help predict drug response or disease risk. interactive explore PUS-POPPIN' FROGS You are the researcher! Use single nucleotide polymorphism (SNP) data to prescribe medications for frogs with bad skin. learn more DRUG DEVELOPMENT TODAY AND TOMORROW Consider how pharmacogenetics might remake the drug development process. learn more CHALLENGES AND ISSUES IN PERSONALIZED MEDICINE Think about some important questions facing pharmacogenomic research.

93. Pharmacogenomics: Medicine And The New Genetics Overview, anticipated benefits, and links to related resources. From the U.S. Human Genome Project. http://www.ornl.gov/sci/techresources/Human_Genome/medicine/pharma.shtml

Human Genome Project Information Genomic Science Program DOE Microbial Genomics home ... Disorders Pharmacogenomics Basic Information FAQs Glossary Acronyms Links ... Media Guide About the Project What is it? Goals Landmark Papers Sequence Databases ... FAQs the New Genetics Home Gene Testing Gene Therapy Pharmacogenomics ... Genetic Counseling Ethical, Legal, Social Issues Home Privacy Legislation Gene Testing Gene Therapy ... Human Migration Education Teachers Students Careers Webcasts ... Genética Websites en Español Research Home Sequence Databases Landmark Papers Insights Publications Chromosome Poster Primer Molecular Genetics List of All Publications Search This Site Contact Us Privacy Statement Site Stats and Credits Site Map Quick Links to questions and answers on this page: What is pharmacogenomics? What are the anticipated benefits of pharmacogenomics? Is pharmacogenomics in use today? What are some of the barriers to pharmacogenomics progress? ... Pharmacogenomics resources What is pharmacogenomics? Pharmacogenomics is the study of how an individual's genetic inheritance affects the body's response to drugs. The term comes from the words pharmacology and genomics and is thus the intersection of pharmaceuticals and genetics.

94. Pharmacogenomics Factsheet Definitions, current research, and future predictions of the use of pharmacogenomics in drug response. http://www.ncbi.nlm.nih.gov/About/primer/pharm.html

National Center for Biotechnology Information About NCBI NCBI at a Glance A Science Primer Databases and Tools ... Site Map Science Primer: Bioinformatics Genome Mapping Molecular Modeling SNPs ... Phylogenetics Just the Facts: A Basic Introduction to the Science Underlying NCBI Resources ONE SIZE DOES NOT FIT ALL: THE PROMISE OF PHARMACOGENOMICS Adverse Drug Reaction. These three simple words convey little of the horror of a severe negative reaction to a prescribed drug. But such negative reactions can nonetheless occur. A 1998 study of hospitalized patients published in the Journal of the American Medical Association reported that in 1994, adverse drug reactions accounted for more than 2.2 million serious cases and over 100,000 deaths, making adverse drug reactions (ADRs) one of the leading causes of hospitalization and death in the United States. Currently, there is no simple way to determine whether people will respond well, badly, or not at all to a medication; therefore, pharmaceutical companies are limited to developing drugs using a "one size fits all" system. This system allows for the development of drugs to which the "average" patient will respond. But, as the statistics above show, one size does NOT fit all, sometimes with devastating results. What is needed is a way to solve the problem of ADRs before they happen. The solution is in sight though, and it is called pharmacogenomics.

95. Pharmacogenomics Research Network - National Institute Of General Medical Scienc Provides information on the institute s pharmacogenetics research network . Includes links to program announcements, news and events, and resources. http://www.nigms.nih.gov/pharmacogenetics/

Skip Navigation NIGMS Home Site Map Staff Search Search: Back to: NIGMS Home Featured Areas NIH Pharmacogenomics Research Network The Pharmacogenomics Research Network and PharmGKB have been renewed. Go to http://www.pgrn.org to learn more about network activities. The next PGRN open scientific meeting will be held April 27, 2011 at University of Maryland at Baltimore. The Pharmacogenomics Knowledge Base ( PharmGKB is an integrated knowledge base for pharmacogenomics linking phenotypes and genotypes. The NIH Pharmacogenomics Research Network (PGRN) is a network of scientists focused on understanding how a person’s genes affect his or her response to medicines. Funded since 2000, the PGRN has a Vision and Mission. The following institutes contribute support to the Pharmacogenomics Research Network: NIGMS NHLBI NCI NIDA ... Research Network Discover more about PGRN scientists, publications, and governing structure. External Scientific Panel Members and purpose of PGRN's scientific advisory panel Global Alliance for Pharmacogenomics Learn about partnerships between PGRN and global scientists. Consortia Learn about PharmGKB projects with the scientific community.

96. Pharmacist.com | Your Access To The World Of Pharmacy And Home Of The American P Provides the history, technology, and application of pharmacogenetics. http://www.aphanet.org/govt/policycomm2000/pharmacobackground.html

97. Pharmacogenetics - Wikipedia, The Free Encyclopedia Online encyclopedia entry on this field which is generally regarded as the study or clinical testing of genetic variation that gives rise to differing response to drugs. http://en.wikipedia.org/wiki/Pharmacogenetics

Pharmacogenetics From Wikipedia, the free encyclopedia Jump to: navigation search For the journal, see Pharmacogenetics (journal) This article needs additional citations for verification Please help improve this article by adding reliable references . Unsourced material may be challenged and removed (May 2007) The terms pharmacogenomics and pharmacogenetics tend to be used interchangeably, and a precise, consensus definition of either remains elusive. Pharmacogenetics is generally regarded as the study or clinical testing of genetic variation that gives rise to differing response to drugs , while pharmacogenomics is the broader application of genomic technologies to new drug discovery and further characterization of older drugs. Pharmacogenetics refers to genetic differences in metabolic pathways which can affect individual responses to drugs, both in terms of therapeutic effect as well as adverse effects. Contents Pharmacogenetics and adverse drug reactions History Thiopurines and TPMT (thiopurine methyl transferase) Hepatitis C ... edit Pharmacogenetics and adverse drug reactions Much of current clinical interest is at the level of pharmacogenetics, involving variation in genes involved in

98. PAAR4Kids Home Identify and evaluate polymorphisms in drug metabolizing enzymes, transporters, or targets relevant to anticancer agents. Includes publications, training, and related links. http://www.pharmacogenetics.org/

Pharmacogenomics of Anticancer Agents Research: PAAR Pharmacogenomics of Anticancer Agents Research Pharmacogenomics of Anticancer Agents Research in Children

99. The Pharmacogenomics Knowledge Base [PharmGKB] Integrated resource about how variation in human genetics leads to variation in response to drugs. http://www.pharmgkb.org/

Sign In Feedback Home Home ... Clinical PGx Our Mission: To collect, encode, and disseminate knowledge about the impact of human genetic variations on drug response. We curate primary genotype and phenotype data, annotate gene variants and gene-drug-disease relationships via literature review, and summarize important PGx genes and drug pathways. You can find what you're looking for by browsing or searching the four major data types we store. If you need a pointer, check out our tutorial . You can also do a general search in the search box at the top of the page. Genes Important PGx genes Pharmacokinetic genes Pharmacodynamic genes Genotyped genes ... examples hint: enter a gene, rsid, drug, disease Variants Annotated SNPs by gene Annotated SNPs by drug Annotated SNPs by disease Download all annotated SNPs ... examples hint: enter a gene, rsid, drug, disease Pathways Pathways by therapeutic categories Pharmacokinetic pathways Pharmacodynamic pathways All pathways ... examples hint: enter a gene, drug, disease Drugs by therapeutic categories Drugs with genetic information Drugs with data examples hint: enter a gene, rsid, drug, disease

100. UCSF PMT - Pharmacogenetics Of Membrane Transporters Database Conduct research and a series of integrated studies to elucidate the pharmacogenetics of membrane transport proteins. Includes information on personnel, publications, training, and available data. http://pharmacogenetics.ucsf.edu/

Gene search: Pharmacogenetics of Membrane Transporters Database You are in: Pharmacogenetics of Membrane Transporters Database The UCSF Pharmacogenetics of Membrane Transporters (PMT) Project is sponsored by the National Institutes of Health's National Institute of General Medical Sciences (grant U01 GM61390). The Project is part of the Pharmacogenetics Research Network and Knowledgebase. Information about the entire Network can be found at PharmGKB . Pharmacogenetics is the study of the genetic basis for variation in response to drugs. Membrane transporters play a major role in drug response in two ways. First, many drugs work by affecting function of transporters. Second, transporters determine the level of drugs within the body by mediating drug absorption, distribution and elimination. Transporters are also determinants of drug resistance. The goal of the UCSF PMT Project is to understand the genetic basis for variation in response for drugs that interact with membrane transporters. Support for the bioinformatics activities of the PMT project also comes from the NIH National Center for Research Resources (grant P41 RR01081).

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