21. Articles By Author: Brown, Michael S.; Collins, Francis; Goldstein, Joseph L.; W Free Online Library Articles by Brown, Michael S.; Collins, Francis; Goldstein, Joseph L.; Watson, James D.; Wexler, Nancy Sabin http://www.thefreelibrary.com/Brown, Michael S.; Collins, Francis; Goldstein, Jo

CacheBuster('') Printer Friendly 18,321,027 articles and books Periodicals Literature Keyword Title Author Topic Member login User name Password Remember me Join us Forgot password? Submit articles free The Free Library Browse Brown, Michael S.; Collins, Francis; Goldstein, Joseph L.; Watson, James D.; Wexler, Nancy Sabin out of article(s) Title Type Date Words Roundtable: the human genome project. Transcript Sep 22, 1993 Publications by Name Publications by Date Authors Literature A-D E-O P-T U-Z ... Submit articles

22. Michael Stuart Brown: Facts, Discussion Forum, And Encyclopedia Article A geneticist is a scientist who studies genetics, the science of heredity and variation of organisms. A geneticist can be employed as a researcher or lecturer. http://www.absoluteastronomy.com/topics/Michael_Stuart_Brown

Home Discussion Topics Dictionary ... Login Michael Stuart Brown Michael Stuart Brown Topic Home Discussion Discussion Ask a question about ' Michael Stuart Brown Start a new discussion about ' Michael Stuart Brown Answer questions from other users Full Discussion Forum Encyclopedia Michael Stuart Brown (born April 13, 1941 in Brooklyn, New York) is an American geneticist Geneticist A geneticist is a scientist who studies genetics, the science of heredity and variation of organisms. A geneticist can be employed as a researcher or lecturer. Some geneticists perform experiments and analyze data to interpret the inheritance of traits.... and Nobel Laureate. He was awarded the Nobel Prize in Physiology or Medicine Nobel Prize in Physiology or Medicine The Nobel Prize in Physiology or Medicine administered by the Nobel Foundation, is awarded once a year for outstanding contributions in the medical field. It is one of five Nobel Prizes established in 1895 by Swedish chemist Alfred Nobel, the inventor of dynamite, in his will, the others being... with Joseph L. Goldstein

23. Regeneron Pharmaceuticals, Inc. (REGN.O) Insider Trading | Reuters.com GOLDSTEIN JOSEPH L Name Age Since Current Position; Vagelos, P. Roy 80 1995 Chairman of the Board Schleifer http://www.reuters.com/finance/stocks/insiderTrading?symbol=REGN.O&name=GOLD

24. Scientific Commons Homocystinuria Heterozygote Detection Using Goldstein, Joseph L., Campbell, Barbara K., Gartler, Stanley M. Abstract Deficiency of cystathionine synthase activity results in the clinical syndrome of homocystinuria. http://en.scientificcommons.org/19150161

25. Michael S. Brown News - The New York Times more on michael s. brown and quotation of the day, blood, medicine and health, cholesterol, goldstein, joseph l http://topics.nytimes.com/topics/reference/timestopics/people/b/michael_s_brown/

@import url(http://graphics8.nytimes.com/css/topic/screen/200704/topic.css); Log In Register Now Help Home Page ... Times Topics Search All NYTimes.com Monday, November 1, 2010 Times Topics World U.S. N.Y. / Region ... B > Brown, Michael S. E-MAIL Michael S. Brown News about Michael S. Brown, including commentary and archival articles published in The New York Times. ARTICLES ABOUT MICHAEL S. BROWN Newest First Oldest First Page: Nation's Largest Medical Prize Goes to 2 for Cholesterol Work By RICHARD PÉREZ-PEÑA Albany Medical Center Prize, nation's largest prize in medicine, is awarded to Dr Joseph L Goldstein and Dr Michael S Brown for their pioneering work on function and control of cholesterol May 1, 2003 MORE ON MICHAEL S. BROWN AND: HEART RESEARCH ALBANY MEDICAL CENTER PRIZE IN MEDICINE AND BIOMEDICAL RESEARCH CHOLESTEROL ... 5 GET LASKER AWARDS FOR ADVANCING PUBLIC HEALTH By WALTER SULLIVAN Five individuals who in diverse ways have made significant contributions to the public health of the nation have been named this year's winners of the Albert Lasker Medical Research and Public Service Awards, each of which includes a $15,000 prize. The Basic Medical Research Award will go to Dr. Michael S. Brown and Dr. Joseph L. Goldstein, of the University of Texas Health Science Center. The two men were recently chosen for the Nobel Prize in Medicine and Physiology for their research on chol... November 21, 1985

26. Retinal Degeneration In Choroideremia: Deficiency Of Rab Geranylgeranyl Transfer Title Retinal Degeneration in Choroideremia Deficiency of Rab Geranylgeranyl Transferase Authors Seabra, Miguel C.; Brown, Michael S.; Goldstein, Joseph L. http://adsabs.harvard.edu/abs/1993Sci...259..377S

Sign on SAO/NASA ADS General Science Abstract Service Find Similar Abstracts (with default settings below Electronic Refereed Journal Article (HTML) References in the article Citations to the Article (7) ... Translate This Page Title: Retinal Degeneration in Choroideremia: Deficiency of Rab Geranylgeranyl Transferase Authors: Publication: Science, Volume 259, Issue 5093, pp. 377-381 ( Sci Homepage Publication Date: Origin: JSTOR DOI: 10.1126/science.8380507 Bibliographic Code: Abstract Rab geranylgeranyl transferase (GG transferase) is a two-component enzyme that attaches 20-carbon isoprenoid groups to cysteine residues in Rab proteins, a family of guanosine triphosphate-binding proteins that regulate vesicular traffic. The mutant gene in human choroideremia, an X-linked form of retinal degeneration, encodes a protein that resembles component A of rat Rab GG transferase. Lymphoblasts from choroideremia subjects showed a marked deficiency in the activity of component A, but not component B, of Rab GG transferase. The deficiency was more pronounced when the substrate was Rab3A, a synaptic vesicle protein, than it was when the substrate was Rab1A, a protein of the endoplasmic reticulum. The data imply the existence of multiple component A proteins, one of which is missing in choroideremia. Bibtex entry for this abstract Preferred format for this abstract (see Preferences Find Similar Abstracts: Use: Authors Title Abstract Text Return: Query Results Return items starting with number

27. A Receptor-Mediated Pathway For Cholesterol Homeostasis Title A ReceptorMediated Pathway for Cholesterol Homeostasis Authors Brown, Michael S.; Goldstein, Joseph L. Publication Science, Volume 232, Issue 4746, pp. 34-47 http://adsabs.harvard.edu/abs/1986Sci...232...34B

Sign on SAO/NASA ADS General Science Abstract Service Find Similar Abstracts (with default settings below Electronic Refereed Journal Article (HTML) References in the article Citations to the Article (61) ... Translate This Page Title: A Receptor-Mediated Pathway for Cholesterol Homeostasis Authors: Publication: Science, Volume 232, Issue 4746, pp. 34-47 ( Sci Homepage Publication Date: Origin: JSTOR DOI: 10.1126/science.3513311 Bibliographic Code: Abstract Not Available Bibtex entry for this abstract Preferred format for this abstract (see Preferences Find Similar Abstracts: Use: Authors Title Return: Query Results Return items starting with number Query Form Database: Astronomy Physics arXiv e-prints

28. Scientific Commons Cystathionine Synthase Activity In Human Goldstein, Joseph L., Campbell, Barbara K., Gartler, Stanley M. Abstract Uncultured human leukocytes contain no detectable cystathionine synthase activity. http://en.scientificcommons.org/11759605

29. Regeneron - Statement Of Changes Of Beneficial Ownership GOLDSTEIN JOSEPH L 2. Issuer Name and Ticker or Trading Symbol REGENERON PHARMACEUTICALS INC REGN 5. Relationship of Reporting Person(s) to Issuer (Check all http://investor.regeneron.com/secfiling.cfm?filingID=1237899-10-23

30. Abstracts: SREBP Cleavage-activating Protein (SCAP) Is Required For Increased Li author Brown, Michael S., Goldstein, Joseph L., Shimomura, Iichiro, Matsuda, Morihiro, Korn, Bobby S., Hammer, Robert E., Moon, YoungAh, Komuro, Ryutaro, Horton, Jay D. http://www.faqs.org/abstracts/Biological-sciences/SREBP-cleavage-activating-prot

@import "/abstracts/css/default.css"; Abstracts search Faqs.org homepage Abstracts index Biological sciences Regulated step in cholesterol feedback localized to budding of SCAP from ER membranes Article Abstract: Results demonstrate that in sterol-treated mammalian cells, the polytopic membrane SREBP Cleaving-Activating-Protein budding is reduced. Data further point out that the budding is from endoplasm reticulum of the sterol treated cells. author: Brown, Michael S., Goldstein, Joseph L., Nohturfft, Axel, Yabe, Daisuke, Espenshade, Peter J. Publisher: Elsevier B.V. Publication Name: Cell Subject: Biological sciences ISSN: Year: Japan, Analysis, Endoplasmic reticulum, Metabolic regulation User Contributions: Comment about this article or add new information about this topic: Comment: (50-4000 characters) Name: E-mail: Security Code: Display my email: SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation Article Abstract: Sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP) has been found to be necessary for increased lipid synthesis in liver brought on by cholesterol deprivation and insulin elevation. The SCAP gene was targeted by flanking exon1 with loxP sites, targets for bacteriophage P1Cre recombinase. Mice homozygous for the loxP-tagged SCAP allele were generated. They carry a transgene encoding Cre under control of the interferon-inducible MX1 promoter. The mice have a major lowering in synthesis of cholesterol and fatty acids. They do not have normal increase in the processes in response to insulin or to cholesterol deprivation.

31. Joseph L. Goldstein (Joseph L. Goldstein Kimdir? - Joseph L. Goldstein Hakkýnda) Joseph L. Goldstein MsXLabs.org Joseph L. Goldstein.jpg Joseph L. Goldstein (d. 18 Nisan 1940) Kingstree, G ney Karolina Nobel d l kazanmış bir biyokimyacı ve http://www.msxlabs.org/forum/bilim-ww/236556-joseph-l-goldstein-joseph-l-goldste

32. Abolish The Insanity Defense-Why Not?1 : The Journal Of Nervous And Mental Disea Abolish the Insanity DefenseWhy Not?1 KATZ, JAY M.D.; GOLDSTEIN, JOSEPH L.L.B., PH.D. http://journals.lww.com/jonmd/Abstract/1964/01000/Abolish_the_Insanity_Defense_W

33. University Of Texas Southwestern Medical Center At Dallas: Facts, Discussion For Start a new discussion about ' University of Texas Southwestern Medical Center at Dallas ' http://www.absoluteastronomy.com/topics/University_of_Texas_Southwestern_Medical

Home Discussion Topics Dictionary ... Login University of Texas Southwestern Medical Center at Dallas University of Texas Southwestern Medical Center at Dallas Topic Home Discussion Discussion Ask a question about ' University of Texas Southwestern Medical Center at Dallas Start a new discussion about ' University of Texas Southwestern Medical Center at Dallas Answer questions from other users Full Discussion Forum Encyclopedia The University of Texas Southwestern Medical Center UT Southwestern or UTSW ) is one of the leading academic medical centers Medical Center A Medical Center is a concentration of medical care providers. The term can be used to refer to* A clinic* A hospital* A larger complex of medical facilities often including hospitals, research facilities, medical schools, and/or other health care facilities.Medical Center may also refer... in the world. It is the flagship biomedical research institution of the University of Texas System University of Texas System The University of Texas System comprises fifteen educational institutions in Texas, of which nine are for academy universities and six are health institutions. The UT System also offers online courses and degrees from UT institutions via the UT TeleCampus. The system is headquartered in Downtown... , incorporating three degree-granting institutions, four affiliated hospitals, including Parkland Memorial Parkland Memorial Hospital Parkland Memorial Hospital is a hospital located at 5201 Harry Hines Boulevard, just west of Oak Lawn in Dallas, Texas . It is the main hospital of the Dallas County Hospital District and serves as Dallas County's public hospital.- History :The original hospital opened in 1894 in a wooden...

34. DANGEROUSNESS AND MENTAL ILLNESS Some Observations On The De... : The Journal Of DANGEROUSNESS AND MENTAL ILLNESS Some Observations on the Decision to Release Persons Acquitted by Reason of Insanity KATZ, JAY M.D.; GOLDSTEIN, JOSEPH L.L.B., Ph.D. http://journals.lww.com/jonmd/Citation/1960/11000/DANGEROUSNESS_AND_MENTAL_ILLNE

35. Sterol Regulatory Elements Brown, Michael S.; Goldstein, Joseph L.; Russell, David W.; Sudhof, Thomas C.; Disclosed are discrete functionally translocatable DNA segments, termed Sterol http://www.devileye.net/catalog/gravity_flow_shelving_system/sterol_regulatory_e

Sterol Regulatory Elements Brown, Michael S.; Goldstein, Joseph L.; Russell, David W.; Sudhof, Thomas C.; BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to DNA segments which may be employed as functionally translocatable genetic control elements. More particularly, the invention relates to sterol regulatory elements and promoter sequences which serve to promote transcription and/or confer a sterol-mediated suppression capability to selected structural genes. 2. Description of the Related Art In the 25 years since Jacob and Monod first proposed the lac operon model and the concept of messenger RNA (see, Jacob et al. (1961), J. Mol. Biol., 3: 318-350), the structure and function of a number of prokaryotic operons has been elucidated in elegant detail. For example, in the case of the lac operon, it has been shown that transcriptional control of the various structural genes of the operon (e.g., B-galactosidase) resides in an upstream (i.e., 5' with respect to the structural genes) regulator gene and operator gene. The regulator gene produces a protein "repressor" that interacts with the operator to prevent transcription initiation of the structural gene. Inducers such as IPTG (isopropyl thiogalactoside) bind to the repressor and thereby induce transcription by preventing the binding of the repressor to the operator. Additionally, there is a promoter site P, upstream of the operator and downstream of the regulatory gene, which serves as an RNA polymerase binding site.

36. Familial Hypercholesterolemia: Defective Binding Of Lipoproteins To Cultured Fib Brown Michael S, Dana Suzanna E, Goldstein Joseph L. Regulation of 3Hydroxy-3-Methylglutaryl Coenzyme A Reductase Activity in Human Fibroblasts by Lipoproteins. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC388099/

window.name="mainwindow"; initRedirectClicks('/pmc/extredirect/') Journal List Proc Natl Acad Sci U S A v.71(3); Mar 1974 Formats: Summary Page Browse PDF (1.0M) Proc Natl Acad Sci U S A. 1974 March; PMCID: Familial Hypercholesterolemia: Defective Binding of Lipoproteins to Cultured Fibroblasts Associated with Impaired Regulation of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Activity Michael S. Brown and Joseph L. Goldstein Division of Gastroenterology-Liver, Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, Texas 75235 Division of Medical Genetics, Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, Texas 75235 This article has been cited by other articles in PMC. Abstract Monolayers of cultured fibroblasts from normal human subjects bind I-labeled low-density lipoproteins from the binding sites, but high-density lipoproteins, the lipoprotein-deficient fraction of serum, and abetalipoproteinemic serum did not. This binding appears to be a required step in the process by which low-density lipoproteins normally suppress the synthesis of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase, the rate-controlling enzyme in cholesterol biosynthesis. The demonstration of a defect in binding of low-density lipoproteins to cells from subjects with the homozygous form of familial hypercholesterolemia appears to explain the previously reported failure of lipoproteins to suppress the synthesis of this enzyme and hence may account for the overproduction of cholesterol that occurs in these cultured cells.

37. Joseph Goldstein - Research Profile On BiomedExperts 2002 Goldstein Joseph L; Rawson Robert B; Brown Michael S Mutant mammalian cells as tools to delineate the sterol regulatory elementbinding protein pathway for feedback regulation http://www.biomedexperts.com/Profile.bme/474938/Joseph_L_Goldstein

38. Joseph Goldstein - Wikipédia, A Enciclopédia Livre Rpt Per GOLDSTEIN JOSEPH L EDGAR is a federally registered trademark of the U.S. Securities and Exchange http://pt.wikipedia.org/wiki/Joseph_L._Goldstein

Joseph Goldstein Origem: Wikipédia, a enciclopédia livre. (Redirecionado de Joseph L. Goldstein Ir para: navegação pesquisa Joseph Leonard Goldstein Nascimento 18 de Abril de Kingstree Nacionalidade Estadunidense Campo(s) Medicina Prêmio(s) Prêmio Albert Lasker de Pesquisa Médica Básica (1985) Nobel de Fisiologia/Medicina (1985) Joseph Leonard Goldstein Kingstree 18 de Abril de ) é um médico geneticista molecular estadunidense Foi agraciado com o Nobel de Fisiologia/Medicina de , por descobertas relativas ao metabolismo do colesterol editar Ligações externas Perfil no sítio oficial do Nobel de Fisiologia/Medicina 1985 (em inglês Precedido por Niels Jerne Georges Köhler e César Milstein Nobel de Fisiologia/Medicina com Michael Stuart Brown Sucedido por Stanley Cohen e Rita Levi-Montalcini v e Nobel de Fisiologia ou Medicina (1976 — 2000) ... Baruch Blumberg e Daniel Gajdusek Roger Guillemin Andrzej Schally e Rosalyn Yalow Werner Arber Daniel Nathans e Hamilton Smith Allan Cormack e Godfrey Hounsfield Baruj Benacerraf Jean Dausset e George Snell Roger Sperry David Hubel e Torsten Wiesel Sune Bergström Bengt Samuelsson e John Vane Barbara McClintock Niels Jerne Georges Köhler e César Milstein Michael Stuart Brown e Joseph Goldstein Stanley Cohen e Rita Levi-Montalcini Susumu Tonegawa James Black Gertrude Elion e George Hitchings John Michael Bishop e Harold Varmus Joseph Murray e Edward Donnall Thomas Erwin Neher e Bert Sakmann Edmond Fischer e Edwin Krebs Richard Roberts e Phillip Sharp Alfred Gilman e Martin Rodbell Edward Lewis Christiane Nüsslein-Volhard e

39. Abstracts: How A Jolt And A Bolt In A DentistEs Chair Revolutionized Cataract Su author Goldstein, Joseph L. Publisher Nature America, Inc. Publication Name Nature Medicine Subject Health http://www.faqs.org/abstracts/Health/How-a-jolt-and-a-bolt-in-a-dentistEs-chair-

@import "/abstracts/css/default.css"; Abstracts search Faqs.org homepage Abstracts index Health Laskers for 2001: knockout mice and test-tube babies Article Abstract: The author discusses this year Lasker Awards that honor the development of two technologies. The technology that allows the scientists to manipulate the mouse genome with exquisite precision and the technology that has revolutionalized the treatment of human infertility have been honored. author: Goldstein, Joseph L. Publisher: Nature America, Inc. Publication Name: Nature Medicine Subject: Health ISSN: Year: Recombinant DNA, Genomes, Infertility User Contributions: Comment about this article or add new information about this topic: Comment: (50-4000 characters) Name: E-mail: Security Code: Display my email: How a jolt and a bolt in a dentistEs chair revolutionized cataract surgery Article Abstract: Cataracts were the leading cause of blindness in the United States until 1970, but today in the United States and many other countries, cataracts no longer hold a significant cause of blindness. A major credit for this goes to Charles D. Kelman, who has received considerable recognition for his legendary contributions to medicine, including every major award in fields of ophthalmology and cataract surgery. author: Goldstein, Joseph L.

40. REGN Insider Trading Transactions, Insider Planned Sales - MSN Money GOLDSTEIN JOSEPH L Sold 400 $28.06 11,224.00 05/14/10 GOLDSTEIN JOSEPH L Exercise 5,000 $25.43 127,150.00 05/14/10 VAGELOS P ROY Sold 20,000 $27.08 541,500.00 http://moneycentral.msn.com/investor/invsub/insider/trans.asp?Symbol=REGN

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