1. Biographies Of Stanley B. Prusiner Biographies of Prusiner Stanley B. and more Prusiner Stanley B. biography. http://www.biography-center.com/biographies/2647-Prusiner_Stanley_B_.html

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2. Neuroscience > Neuroscientists > Prusiner, Stanley B. Rae Fry talks to the discoverer of prions (which cause CreutzfeldtJakob disease) Dr Stanley Prusiner who won the Nobel Prize for his discovery http://www.einet.net/directory/181924/Prusiner_Stanley_B.htm

3. Dictionary - MSN Encarta Enter a search term above to find Dictionary definitions or click the Thesaurus tab to find synonyms and antonyms. http://www.encarta.msn.com/encyclopedia_761596664/Prusiner_Stanley_B_.html

4. Stanley B. Prusiner - Autobiography Nobelprize.org, The Official Web Site of the Nobel Prize http://nobelprize.org/nobel_prizes/medicine/laureates/1997/prusiner-autobio.html

Home FAQ Press Contact Us ... Nobel Prize in Medicine Stanley B. Prusiner - Autobiography About the Nobel Prizes Facts and Lists Nobel Prize in Physics Nobel Prize in Chemistry ... Nobel Prize Award Ceremonies Sort and list Nobel Prizes and Nobel Laureates Create a List All Nobel Prizes Nobel Prize Awarded Organizations Women Nobel Laureates Nobel Laureates and Universities Prize category: Physics Chemistry Medicine Literature Peace Economics The Nobel Prize in Physiology or Medicine 1997 Stanley B. Prusiner The Nobel Prize in Physiology or Medicine 1997 Summary Press Release Illustrated Information ... Other Resources Autobiography My history is not atypical of many Americans: born in the midwest, educated in the East, and now living in the West. My early years were shared between Des Moines, Iowa and Cincinnati, Ohio. Shortly after I was born on May 28, 1942 in Des Moines, my father, Lawrence, was drafted into the United States Navy. I was named for my father's younger brother who died of Hodgkin's disease at the age of 24. We moved to Boston briefly where my father enrolled in Naval officer training school before being sent to the south Pacific. He served as a communications officer for the remainder of World War II on an island called Eniwetok where the first hydrogen bomb was detonated a decade later. During my father's absence, my mother, Miriam, and I lived in Cincinnati where her mother, Mollie Spigel, also lived. Prior to moving to Cincinnati, Mollie had lived in Norfolk, Virginia, where she raised three children after her husband Benjamin was killed at age 50 in a traffic accident. Besides many special memories of my maternal grandmother, I have many fond reminiscences of my paternal grandfather, Ben, who emigrated to the United States in 1896 as a young boy from Moscow. He grew up in Sioux City, Iowa, as did my father with many other Russian Jews. Shortly after the end of World War II, we returned to Des Moines where I attended primary school and my brother, Paul, was born. In 1952, we moved back to Cincinnati with the hope that my father would be able to find a much better job as an architect. In Cincinnati, he practiced architecture for the next 25 years, which enabled him to provide a very comfortable home for his family.

5. Stanley B. Prusiner - Article And Reference From OnPedia.com Since that time, Prusiner has held various faculty and visiting faculty positions at both UCSF and University of California, Berkeley. Prusiner, Stanley B. Prusiner, Stanley B http://www.onpedia.com/encyclopedia/stanley-b.-prusiner

Stanley B. Prusiner Stanley B. Prusiner, M.D. is a Professor of Neurology and Biochemistry at the University of California, San Francisco . He received the Albert Lasker Award for Basic Medical Research in and was awarded the Nobel Prize in physiology or medicine in for his discovery of prions , a class of infectious self-reproducing agents composed of protein . Born in Des Moines, Iowa , Prusiner spent his childhood in Des Moines and Cincinnati, Ohio , where he attended Walnut Hills High School . Upon his graduation, Prusiner attended the University of Pennsylvania . Prusiner received both his undergraduate degree in Chemistry and his M.D. from Penn. Prusiner then completed an internship in medicine at UCSF. From there, Prusiner went to the National Institutes of Health , where he studied glutaminases in E. coli in the laboratory of Earl Stadtman. After three years at NIH, Prusiner returned to UCSF to complete a residency in Neurology. Upon completion of that residency in 1974, Prusiner joined the faculty of the Neurology department at UCSF. Since that time, Prusiner has held various faculty and visiting faculty positions at both UCSF and University of California, Berkeley

6. Stanley B. Prusiner - Wikipedia, The Free Encyclopedia Stanley Ben Prusiner (born May 28, 1942) is an American neurologist and biochemist. Currently the director of the Institute for Neurodegenerative Diseases at University of California http://en.wikipedia.org/wiki/Stanley_B._Prusiner

Stanley B. Prusiner From Wikipedia, the free encyclopedia Jump to: navigation search Stanley Prusiner Prusiner in 2007 Born May 28, 1942 Des Moines, Iowa , United States Residence San Francisco , United States Nationality American Fields Neurology infectious disease Institutions University of California, San Francisco Alma mater University of Pennsylvania University of Pennsylvania School of Medicine ... Creutzfeldt-Jakob disease Notable awards Nobel Prize in Physiology or Medicine Potamkin Prize Lasker Award Stanley Ben Prusiner (born May 28, 1942 ) is an American neurologist and biochemist . Currently the director of the Institute for Neurodegenerative Diseases at University of California, San Francisco (UCSF). Prusiner discovered prions , a class of infectious self-reproducing pathogens primarily or solely composed of protein . He received the Albert Lasker Award for Basic Medical Research in 1994 and the Nobel Prize in Physiology or Medicine in 1997 for his prion research. Contents Early life and career Nobel prize and academic societies Awards References ... edit Early life and career Prusiner was born in Des Moines, Iowa

7. Abstracts: Propagation Of Prions With Artificial Properties In Transgenic Mice E author Prusiner, Stanley B., Scott, Michael, DeArmond, Stephen J., Cohen, Fred E., Torchia, Marilyn, Suppaattapone, Surachai, Bosque, Patrick, Muramoto, tamaki, Wille, Holger http://www.faqs.org/abstracts/Biological-sciences/Propagation-of-prions-with-art

@import "/abstracts/css/default.css"; Abstracts search Faqs.org homepage Abstracts index Biological sciences Propagation of prions with artificial properties in transgenic mice expressingchimeric PrP genes Article Abstract: Transgenic mice with chimeric prior protein genes derived from Syrian hamster and mouse genes show, when constructed, that one Syrian hamster gene designated MH2M PrP contains five amino acid substitutions while another construct, designated MHM2 PrP, has possess two substitutions. Transgenic MH2M PrP mice were vulnerable to both Syrian hamster and mouse prions. Findings of the study support genetic evidence for homophilic intercourse between PrPSc in the inoculum and Prpc absorbed by the host. author: Prusiner, Stanley B., Scott, Michael, Foster, Dallas, DeArmond, Stephen J., Groth, Darlene, Torchia, Marilyn, Shu-Lian Yang Publisher: Elsevier B.V. Publication Name: Cell Subject: Biological sciences ISSN: Year: Genetic aspects, Mice, Mice (Rodents), Genetics User Contributions: Comment about this article or add new information about this topic: Comment: (50-4000 characters) Name: E-mail: Security Code: Display my email: Prion protein of 106 residues creates an artificial transmission barrier for prion replication in transgenic mice Article Abstract: A study was conducted to determine the minimal size and the number of N-terminal residues that can be deleted from transgenic mice's cellular prion proteins without inhibiting prion propagation. Results indicate that a redacted prion protein (PrP) of 106 amino acids with two deletions can still support prion propagation. Further studies revealed that removal of 50% of the residues of PrP will still allow prion propagation through its remaining polypeptides.

8. Prusiner, Stanley B. Definition - Medical Dictionary Definitions Of Popular Medi Online Medical Dictionary and glossary with medical definitions http://www.medterms.com/script/main/art.asp?articlekey=26278

9. Prusiner, Stanley B. PRUSINER, STANLEY B., U.S.A 1997 for his discovery of Prions a new biological principle of infection DOHERTY, PETER C., Australia ZINKERNAGEL, ROLF M., Switzerland http://www.cartage.org.lb/fr/themes/Biographies/mainbiographie/P/Prusiner/Prusin

Prusiner, Stanley B. Mon histoire n'est pas atypique de beaucoup d'Américains: né au Midwest, instruit à l'Est et vivant maintenant à l'Ouest. Mes premières années ont été partagées entre Des Moines, l'Iowa et Cincinnati, l'Ohio. Peu de temps après je suis né le 28 mai 1942 dans Des Moines, mon père, Lawrence, ai été rédigé dans les Etats-Unis la Marine. J'ai été nommé pour le frère plus jeune de mon père qui est mort de la maladie d'Hodgkin à l'âge 24. Nous n'avons déplacé à Boston brièvement où mon père inscrit à l'école de formation d'officier Navale avant (auparavant) être envoyé au Pacifique du sud. Il a servi comme un officier de communications pour le reste de Deuxième Guerre mondiale dans une île appelée Eniwetok où la première bombe hydrogène a été faite détoner une décennie plus tard. Pendant mon temps au Lycée de Collines de Noix, j'ai étudié le latin pendant cinq ans, qui devaient m'aider immensément plus tard dans l'écriture de papiers scientifiques. Mais j'ai trouvé le lycée assez non intéressant et étais le plus chanceux pour être accepté par l'Université de la Pennsylvanie où je me suis spécialisé en Chimie. Au NIH, j'ai travaillé dans le laboratoire du Comte Stadtman où j'ai étudié glutaminases dans E. coli. Mes trois ans au NIH étaient critique dans mon éducation scientifique. J'ai appris une quantité (somme) immense du processus de recherche: des essais de développement, des macromolécules d'épuration, la documentation une découverte par beaucoup d'approches et l'écriture purifie des manuscrits décrivant que l'on sait (connaît) et quels restes être examiné. Comme la fin de mon temps au NIH a commencé à près, j'ai examiné des camaraderies post-doctorales dans la neurobiologie, mais ai décidé qu'une résidence dans la Neurologie était un meilleur itinéraire au développement d'une carrière utile dans la recherche. La résidence m'a offert une occasion d'apprendre et de système nerveux normal et incorrect.

10. UCSF - Prusiner Laboratory - Stanley B. Prusiner, M.D. The Prusiner Laboratory website has been moved. The new address is below. Please update your bookmarks. We look forward to seeing you on our new site. http://prusinerlab.ucsf.edu/people/director.php

Director Faculty Post Docs Research Staff Administration The Prusiner Laboratory website has been moved. The new address is below. Please update your bookmarks. We look forward to seeing you on our new site. http://ind.ucsf.edu Last updated: June 09 2010 16:50. Prusiner Lab Home Overview Publications Jobs ... Print version

11. From Sheep To Humans: Scrapie And Creutzfeldt-Jakob Disease Prusiner, Stanley B Prions causing degenerative neurological diseases. Annual Review of Medicine, Vol. 38, 1987, 381398. For a summary of other theories cf. the http://www.ecclectica.ca/issues/2002/2/george.asp

From Sheep to Humans: Scrapie and Creutzfeldt-Jakob Disease From Sheep to Humans: Scrapie and Creutzfeldt-Jakob Disease by Rolf George Professor of Philosophy, University of Waterloo Creutzfeldt-Jakob Disease , first described in 1920, is an always fatal degenerative disease of the central nervous system and belongs to the class of transmissible spongiform encephalopathies (TSE). "Classical" CJD can run in families (15%), while other infections have followed surgical procedures and transplants of cornea or brain tissue (dura), and administration of growth hormone (5%). The remaining cases are sporadic, that is, without explanation. They are widely and irregularly distributed, with the incidence rarely higher than, and usually below, one case in a million population per year. In several countries women are infected more often, sometimes twice as often, as men are. TSE's in other species are the bovine form (BSE), or mad cow disease, scrapie in sheep, and chronic wasting disease (CWD) in deer and elk. TSE's cross species barriers and are now found, or have been induced in, mice, cats, bisons, cheetahs, pumas, tigers, ocelots, kudus, apes and other mammals and birds. As well, BSE has crossed to humans, forming a "variant" of Creutzfeldt Jakob (vCJD) Scrapie was first identified in the 18th century. It was widely thought to be hereditary until in March 1935 18,000 sheep were injected with a scrapie contaminated vaccine aimed at controlling another disease (louping-ill). A surprising aspect of the case was that the infective agent had survived weeklong storage in formaldehyde. A controlled experiment using 788 animals confirmed the transmissible nature of the disease. After four and a half years 60% of intracerebrally, and 30% of subcutaneously inoculated were clinically affected

12. Stanley B. Prusiner Winner Of The 1997 Nobel Prize In Medicine Stanley B. Prusiner, a Nobel Prize Laureate in Physiology and Medicine, at the Nobel Prize Internet Archive. http://nobelprizes.com/nobel/medicine/1997a.html

S TANLEY B P RUSINER 1997 Nobel Laureate in Medicine for his discovery of Prions - a new biological principle of infection. Background Born: May 28, 1942 Place of birth: U.S.A. Residence: San Francisco, U.S.A. Affiliation: Department of Neurology, University of California, School of Medicine, San Francisco, CA 94143, USA Book Store Books by Stanley B Prusiner Prion Biology and Diseases (Cold Spring Harbor Monograph Series, No. 38) Books on Prion Diseases Books on Alzheimer's Disease Books on Kuru Books on Neuropathology ... Books on Neurodegenerative Diseases Featured Internet Links Official award announcement and background Illustrated Presentation Biography Curriculum Vitae ... DC Gajdusek and BS Blumberg 1976 Nobel Prize winning research on kuru PubMedline search results for this laureate PubMedline search results for prions Search WWW Search The Nobel Prize Internet Archive Links added by Nobel Internet Archive visitors A backgrounder on prions in the context of the Mad Cow Disease The Official Mad Cow Disease Home Page National Institute of Neurological Disorders and Stroke Scientific American prion article by Dr. Prusiner (submitted by Bob Hadsell CNN coverage of Dr. Prusiner's prizewinning experience

13. Patent 6,419,916 Title Assay for compounds which affect conformationally altered proteins United States Patent 6,419,916 . Inventors Prusiner; Stanley B. (San Francisco, CA http://www.pharmcast.com/Patents/Yr2002/July2002/071602/6419916_Protein071602.ht

Pharm/Biotech Resources Outsourcing Guide Cont. Education ... Site Map Title: Assay for compounds which affect conformationally altered proteins United States Patent: Inventors: Prusiner; Stanley B. (San Francisco, CA); Supattapone; Surachai (San Francisco, CA); Scott; Michael R. (San Francisco, CA) Assignee: The Regents of the University of California (Oakland, CA) Appl. No.: Filed: September 28, 1999 Abstract An assay comprises contacting cells containing a conformationally altered protein with test compound and determining if the altered protein is cleared. The cells may be scrapie-infected neuroblastoma cells. Another assay comprises contacting organ or tissue homogenate (at pH 5.0 or less) with test compound to determine if altered protein in the homogenate is 10 cleared. The homogenate may be brain homogenate from a transgenic mouse infected with human prions. Compounds which are found to clear the altered protein are useful in preventing, arresting and/or reversing (i.e. treating) a disease associated with the conformationally altered protein. SUMMARY OF THE INVENTION An assay is provided whereby compounds are tested to determine their potential efficacy as therapeutics for the treatment of disorders associated with conformationally altered protein, e.g. prion diseases associated with the PrP

14. Prusiner, Stanley B - Define Prusiner, Stanley B At WordIQ Online Dictionary Prusiner, Stanley B. Prusiner, Stanley B. American neurologist (1942) and winner of the Nobel Prize for the discovery of prions - a new biological principle of infection. http://www.wordiq.com/prusiner,_stanley_b

/**/ @import "/knowledge/stylesheets/monobook/main.css"; /**/ Prusiner, stanley b - Dictionary Definition and Overview Prusiner, Stanley B. Prusiner, Stanley B.: American neurologist (1942-) and winner of the Nobel Prize for the discovery of "prions - a new biological principle of infection." Prusiner received his A.B. in chemistry in 1964 and his M.D. in 1968 from the University of Pennsylvania. Following his internship at the University of California, San Francisco (UCSF), he came to the National Heart and Lung Institute, part of the National Institutes of Health (NIH), in 1969. Working there in Earl Stadtman's laboratory, he learned various aspects of the research process in biochemistry: developing assays, purifying macromolecules, documenting a discovery by many approaches, and writing clear manuscripts describing what is known and what remains to be investigated. As he later recalled, his three years at NIH were critical in his scientific education. In 1972, Prusiner began a residency at UCSF in the department of neurology, where he became interested in a "slow virus" infection called Creutzfeld-Jakob disease (CJD) and the seemingly related diseases nucleic acid having genetic information. Prusiner's paper immediately set off a firestorm of criticism, especially from virologists, but by the mid-1990s, his discovery had become widely accepted. And in 1997 he was awarded the Nobel Prize in Physiology or Medicine.

15. Patent 6,406,864 Title Assay for disease related conformation of a protein and isolating same United States Patent 6,406,864. Inventors Prusiner; Stanley B. (San Francisco, CA http://www.pharmcast.com/Patents/Yr2002/June2002/061802/6406864_Protein061802.ht

Pharm/Biotech Resources Outsourcing Guide Cont. Education ... Site Map Title: Assay for disease related conformation of a protein and isolating same United States Patent: Inventors: Prusiner; Stanley B. (San Francisco, CA); Safar; Jiri G. (Concord, CA) Assignee: The Regents of the University of California (Oakland, CA) Appl. No.: Filed: January 3, 2001 Abstract An assay method is disclosed which isolates and detects the presence of a disease related conformation of a protein (e.g., PrP Sc ) present in a sample also containing the non-disease related conformation of the protein (e.g., PrP C ). The sample is treated (e.g., contacted with protease) in a manner which hydrolyzes the disease related conformation and not the non-disease related conformation. The treated sample is contacted with a binding partner (e.g., a labeled antibody which binds PrP Sc ) and the occurrence of binding provides and indication that PrP Sc is present. Alternatively the PrP

16. PRUSINER, STANLEY B. - CIRS PRUSINER, STANLEY B. Email stanley (AT) itsa.ucsf.edu Professor of Neurology and Biochemistry and Biophysics at the University of California, San Francisco, CA, USA http://www.cirs-tm.org/researchers/researchers.php?id=389

17. - Encyclopedie - Medicalorama Prusiner, Stanley B. 5/28/1942 to American Discovery of prions; a new biological principle of infection; 2000 Carlsson, Arvid 1/25/1923 to Swedish Signal transduction in the nervous http://www.medicalorama.com/encyclopedie/10915

18. Stanley B. Prusiner - CIRS PRUSINER, STANLEY B. stanley@itsa.ucsf.edu. Professor of Neurology and Biochemistry and Biophysics http://www.cirs.net/researchers/medicine/PRUSINER.htm

PRUSINER, STANLEY B. stanley@itsa.ucsf.edu Professor of Neurology and Biochemistry and Biophysics at the University of California , San Francisco, CA, USA Research interests : Stanley Prusiner discovered an entirely new class of pathogens that replicate without nucleic acid. Through this work, he created a new field of research that has resulted in significant progress in understanding degenerative diseases of the central nervous system (CNS). His revolutionary studies have made conceptual advances in elucidating mechanisms of age-dependent CNS diseases. Awards : - Potamkin Prize for Alzheimer's Disease Research, American Academy of Neurology, 1991 - Christopher Columbus Quincentennial Discovery Award in Biomedical Research, NIH, 1992 Metropolitan Life Foundation Award for Medical Research, 1992 - Dickson Prize for Distinguished Scientific Accomplishments, University of Pittsburgh, 1992 - Charles A. Dana Award for Pioneering Achievements in Health, 1992 - Richard Lounsbery Award for Extraordinary Scientific Research, NAS, 1993 - Gairdner Foundation Award for Outstanding Achievement in Medical Science, 1993

19. Stanley B. Prusiner - Discussion And Encyclopedia Article. Who Is Stanley B. Pru Stanley B. Prusiner Stanley B. Prusiner, M.D., a Professor of Neurology and Biochemistry at the University of California, San Francisco. was awarded the Nobel Prize in physiology or http://www.knowledgerush.com/kr/encyclopedia/Stanley_B._Prusiner/

20. Stanley B. Prusiner (American Biochemist And Neurologist) -- Britannica Online E Stanley B. Prusiner (American biochemist and neurologist), May 28, 1942Des Moines, Iowa, U.S.American biochemist and neurologist whose discovery in 1982 of diseasecausing proteins http://www.britannica.com/EBchecked/topic/480887/Stanley-B-Prusiner

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