21. Prions Title Prions Authors Prusiner, Stanley B. Publication Proceedings of the National Academy of Sciences of the United States of America, Volume 95, Issue 23, pp. 1336313383 http://adsabs.harvard.edu/abs/1998PNAS...9513363P

Sign on SAO/NASA ADS General Science Abstract Service Find Similar Abstracts (with default settings below Electronic On-line Article (HTML) Full Printable Article (PDF/Postscript) Citations to the Article (69) ... Translate This Page Title: Prions Authors: Publication: Proceedings of the National Academy of Sciences of the United States of America, Volume 95, Issue 23, pp. 13363-13383 Publication Date: Origin: JSTOR Bibliographic Code: Abstract Prions are unprecedented infectious pathogens that cause a group of invariably fatal neurodegenerative diseases by an entirely novel mechanism. Prion diseases may present as genetic, infectious, or sporadic disorders, all of which involve modification of the prion protein (PrP). Bovine spongiform encephalopathy (BSE), scrapie of sheep, and Creutzfeldt-Jakob disease (CJD) of humans are among the most notable prion diseases. Prions are transmissible particles that are devoid of nucleic acid and seem to be composed exclusively of a modified protein (PrP Sc ). The normal, cellular PrP (PrP

22. Molecular Biology And Genetics Of Prion Diseases Title Molecular Biology and Genetics of Prion Diseases Authors Prusiner, Stanley B. Publication Philosophical Transactions Biological Sciences, Volume 343, Issue 1306, pp http://adsabs.harvard.edu/abs/1994RSPTB.343..447P

Sign on SAO/NASA ADS General Science Abstract Service Find Similar Abstracts (with default settings below Electronic Refereed Journal Article (HTML) References in the article Citations to the Article (1) ... Translate This Page Title: Molecular Biology and Genetics of Prion Diseases Authors: Publication: Philosophical Transactions: Biological Sciences, Volume 343, Issue 1306, pp. 447-463 Publication Date: Origin: JSTOR Bibliographic Code: Abstract Sc and PrP C suggest that the difference is conformational. Whether one or more putative alpha -helices in PrP C are converted into beta -sheets during synthesis of PrP Sc is unknown. Distinct prion isolates or `strains' exhibit different patterns of PrP Sc accumulation which are independent of incubation times. Whether variations in PrP Sc conformation are responsible for prion diversity remains to be established. Prion studies have given new insights into the etiologies of infectious, sporadic and inherited degenerative diseases. Bibtex entry for this abstract Preferred format for this abstract (see Preferences Find Similar Abstracts: Use: Authors Title Abstract Text Return: Query Results Return items starting with number Query Form Database: Astronomy Physics arXiv e-prints

23. Stanley B. Prusiner: Books By Stanley B. Prusiner @ BookFinder.com Search engine that finds the best buys from among 150 million new, used, rare, and outof-print books for sale, including books by Stanley B. Prusiner. http://www.bookfinder.com/author/stanley-b-prusiner/

24. Prion Biology And Diseases-2nd Ed-#41 By Stanley B. Prusiner, Stanley B. Pruisne Flipkart.com Prion Biology And Diseases2nd Ed- 41 by Stanley B Prusiner Stanley B Pruisner Stanley B Prusiner. Rs.8691. Buy Prion Biology And Diseases-2nd Ed- 41, All India http://www.flipkart.com/prion-biology-diseases-2nd-ed-book-0879696931

Home My Account Wishlist Help ... View Cart Books Music Games Mobiles The store at your door Books Prion Biology And Diseases-2nd Ed-#41 (Hardcover) by Stanley B. Prusiner (Author) Stanley B. Pruisner (Author) Stanley B Prusiner (Author) Write a Review List Price: Rs. 8369 Our Price: Rs. 8369 (Inclusive of all taxes) Discount: Rs. Imported Edition. Order now and get it in 14-21 business days See Details Buy online using: - Credit Card / Debit Card / Internet Banking - Cash-on-Delivery. See Details Publisher: Cold Spring Harbor Laboratory Press (Jan 2004) OR Book Summary of Prion Biology And Diseases-2nd Ed-#41 This volume is a new edition of the most authoritative book on Prion Biology, first published in 1999 and edited by the Nobel Prize-winning founder of the field. This expanded edition has been completely updated, and includes chapters on therapeutics, and diagnostic methods and approaches. top Details of Book: Prion Biology And Diseases-2nd Ed-#41 Book: Prion Biology And Diseases-2nd Ed-#41 Author: Stanley B. Prusiner, Stanley B. Pruisner, Stanley B Prusiner ISBN: ISBN-13: Binding: Hardcover Publishing Date: Jan 2004 Publisher: Cold Spring Harbor Laboratory Press Edition: 2nd Edition Number of Pages: Language: English Related Tags prion biology and diseases stanley b prusiner contact stanley prusiner prion biology and diseases by stanley b prusiner prion biology and diseases second edition stanley b prusiner prion biology diseases by prusiner diseases spring harbor 2nd stanley prusiner 2009 stanley b prusiner y los priones

25. Models Of Prion Disease Prusiner, Stanley B.; Korth, Carsten; The present invention provides a novel PrP protein, and nucleic acids encoding http://www.devileye.net/catalog/slotting_cutter/models_prion_disease.html

Models of prion disease Prusiner, Stanley B.; Korth, Carsten; The present invention provides a novel PrP protein, and nucleic acids encoding this protein, where the PrP protein is characterized in vivo by 1) incomplete glycosylation relative to glycosylation of wild-type PrP.sup.C and 2) proper cellular localization, i.e. an ability to be transported to the cell surface. This novel, under-glycosylated PrP, unlike its normal cellular counterpart, can easily be converted into a protease-resistant isoform by incubation with infectious prions. The invention further provides systems for the study of prion disorders and methods of using these systems, e.g. the study of the mechanical processes in progression of prion-mediated disease or the identification of new therapeutic agents for treatment of prion-mediated disorders. In such systems, protease-resistant under-glycosylated PrP is generated de novo and can be detected by standard immunoblot techniques. FIELD OF THE INVENTION The present invention relates generally to systems for studying neurodegenerative disorders, and in particular to systems for the study of prion-associated disease. BACKGROUND OF THE INVENTION Prions are infectious pathogens that cause central nervous system spongiform encephalopathies in humans and animals. Prions are distinct from bacteria, viruses and viroids. The predominant hypothesis at present is that no nucleic acid component is necessary for infectivity of prion protein. Further, a prion which infects one species of animal (e.g., a human) will not readily infect another (e.g., a mouse).

26. Method Of Sterilizing Prusiner, Stanley B.; Supattapone, Surachai; Scott, Michael R.; A method of sterilizing objects as well as the sterilized objects obtained from http://www.devileye.net/catalog/toner/sterilizing.html

Method of sterilizing Prusiner, Stanley B.; Supattapone, Surachai; Scott, Michael R.; A method of sterilizing objects as well as the sterilized objects obtained from the method are disclosed. The method involves contacting an object such as a medical device to be reused with polycationic dendrimer under conditions which result in rendering a conformationally altered protein (e.g. a prion) non-infectious. A disinfecting agent or surgical scrub composition which comprises the dendrimers is also disclosed as are gelatin capsules treated with polycationic dendrimers. FIELD OF THE INVENTION The present invention relates generally to methods of sterilizing materials and particularly to a method of inactivating infectious prions. BACKGROUND OF THE INVENTION There are large numbers of known methods of sterilizing materials. Many methods involve heating a material to a temperature at which pathogens are killed or inactivated. Other methods involve exposing the material to compounds which kill or inactivate pathogens which are contacted by the compounds. Still other methods involve irradiating a material with a sufficient amount of a particular type of radiation for a period of time sufficient to inactivate, disrupt or kill pathogens in the material. These methods are generally directed toward killing bacteria and inactivating viruses present in or on the material. Although sterilization methods may be quite affective in killing bacteria or inactivating viruses, they do not generally inactivate pathogenic proteins such as prions which can be responsible for a number of fatal diseases.

27. Prusiner, Stanley B. - Personenlexikon CreutzfeldtJakob Disease and Scrapie Prions PRUSINER, STANLEY B. M.D. Creutzfeldt-Jakob disease, kuru, and Gerstmann-Straussler syndrome are http://www.personenlexikon.net/d/prusiner-stanley-b/prusiner-stanley-b.htm

Startseite Personenlexikon Thematische Gliederung Gruppen Kategorien ... Z Prusiner, Stanley B. amerikanischer Mediziner, Neurologe und Biochemiker, geboren 28.5.1942 Des Moines, Iowa; seit 1984 Professor f�r Neurologie an der University of California in San Francisco und Gastprofessor f�r Virologie in Berkeley, zudem seit 1988 Professor f�r Biochemie in San Francisco; entdeckte die Prion-Proteine und konnte mutierte Prion-Proteine als verursachendes Agens f�r die Entstehung hirnzerst�render Krankheiten wie Bovine Spongiforme Encephalopathie (BSE, Rinderwahnsinn), CreutzfelJako- -Erkrankung, Kuru und Scrapie nachweisen; die Annahme, da� Prion-Proteine keine DNA enthalten, widerspricht dem bisherigen Dogma, nach dem sich infekti�se Erreger nicht ohne genetisches Material (DNA/RNA) vermehren k�nnen; erhielt 1997 den Nobelpreis f�r Physiologie oder Medizin. Diese Seite als Bookmark speichern : addthis_url = location.href; addthis_title = document.title; addthis_pub = 'woorgle1492'; Prout, William

28. Biology Of Prion Diseases : JAIDS Journal Of Acquired Immune Deficiency Syndrome June 1993 Volume 6 - Issue 6 - ppg 663-665 Biology of Prion Diseases Prusiner, Stanley B. http://journals.lww.com/jaids/Citation/1993/06000/Biology_of_Prion_Diseases.23.a

29. What's All The Fuss About Prion Diseases? Prusiner, Stanley B. The Prion Diseases in Scientific American, Vol. 272, No. 1, January 1995. Prusiner, Stanley B. Detecting Mad Cow Disease in Scientific American, Vol. 291 http://www.northfortynews.com/Archive/A200411Prions.htm

November 2004 Events News Archive Home Page ... Community Page What's all the fuss about prion diseases? By Gary Raham Correspondent Human nervous system diseases caused by minute protein fragments called prions (pronounced "pree-ons") include Creutzfeldt-Jakob disease, kuru, Gerstmann-Straussler-Scheinker disease and fatal familial insomnia. Yes, they are incurably fatal, and yes, families must watch loved ones die slowly with a gradual loss of mental function, but only a few hundred cases have been documented worldwide. Contrast that to flu epidemics that can take millions of lives at a time. Why get unduly worried about rare transmissions of prions between species, as with the "mad cow" epidemic or recent concerns about chronic wasting disease (CWD) in deer and elk? Why pour money into research on "one-in-a-million" diseases? The answer to the first question is easy: Prion diseases are scary. The answer to the second is uniquely human: Prion diseases are weird and we want to know why. Curiosity has been a fruitful human ally in the past. Prion diseases challenge what we think we know about biology.

30. Stanley B. Prusiner Stanley B. Prusiner . Stanley B. Prusiner. Stanley B. Prusiner AKA Stanley Benjamin Prusiner. Born 28 May-1942 NNDB MAPPER, Create a map starting with, Stanley B. Prusiner http://www.kosmix.com/topic/Stanley_B._Prusiner

Kosmix One sec... we're building your guide for Stanley B. Prusiner document.k_start_apptier = "Nov 01 01:40:28.615711"; kapp.assignCol($('ads_banner_top'), 'topnav_container'); Stanley B. Prusiner Overview Reference Images Video ... Shopping kapp.nav_menu_container = $('refine_nav').down(".navs_container"); kapp.assignCol($('refine_nav'), 'topnav_container'); kapp.assignCol($('uc_kosmixarticles_shadow'), 'right_container'); Video for Stanley B. Prusiner Video Search from Truveo Interview With Stanley B. Prusiner ... From: Nobel Prize kapp.mCallback($('video_trv')); More Video from Truveo kapp.assignCol($('video'), 'left_container'); You May Also Like Kosmix Meir Wilchek Meir Wilchek (Hebrew: מאיר אשר וילצ'ק, born in 1935) is an Israeli biochemist. He is a professor at ... Roger Y. Tsien Roger Yonchien Tsien (; born February 1, 1952) is an American biochemist and a professor at the Department of Chemistry and Biochemistry ... Mario Capecchi Mario Renato Capecchi (born 6 October 1937) is an Italian-born American molecular geneticist and a co-winner of the 2007 Nobel ... Oliver Smithies Oliver Smithies (born June 23, 1925) is a British-born American geneticist and Nobel laureate, credited with the invention of ...

31. Scientific Commons Doppel-induced Cerebellar Degeneration In Prusiner, Stanley B., Hood, Leroy, Westaway, David, DeArmond, Stephen J., Tremblay, Patrick; Abstract Doppel (Dpl) is a paralog of the mammalian prion protein (PrP); it is abundant in http://en.scientificcommons.org/11570023

32. Edge: STANLEY B. PRUSINER Stanley B. Prusiner. STANLEY B. PRUSINER M.D., is Director of the Institute for Neurodegenerative Diseases and Professor of Neurology and Biochemistry at the University of California http://www.edge.org/3rd_culture/bios/prusiner.html

Home About Edge Features Edge Editions ... Search Stanley B. Prusiner STANLEY B. PRUSINER M.D., is Director of the Institute for Neurodegenerative Diseases and Professor of Neurology and Biochemistry at the University of California, San Francisco. In 1997 he was awarded the Nobel Prize in Physiology or medicine for his discovery of prions, a new class of pathogens that replicate without nucleic acid. Through this work, he created a new field of research that has resulted in significant progress in understanding degenerative diseases of the central nervous system (CNS). Beyond Edge Prusiner Laboratory Nobel Prize Autobiography

33. Stanley Prusiner - Research Profile On BiomedExperts 2003 Ryou Chongsuk; Prusiner Stanley B; Legname Giuseppe Cooperative binding of dominantnegative prion protein to kringle domains. Journal of molecular biology 2003;329(2)323-33. http://www.biomedexperts.com/Profile.bme/1142898/Stanley_B_Prusiner

34. Stanley Prusiner - Wikipédia, A Enciclopédia Livre Prusiner, Stanley B., Cohen, Fred E. Abstract Recent progress determining the structure of the hostencoded prion protein (PrPC) and the role of auxiliary molecules in prion http://pt.wikipedia.org/wiki/Stanley_B._Prusiner

Stanley Prusiner Origem: Wikipédia, a enciclopédia livre. (Redirecionado de Stanley B. Prusiner Ir para: navegação pesquisa Stanley Ben Prusiner Nascimento 18 de Maio de Des Moines Nacionalidade Estadunidense Campo(s) Medicina Prêmio(s) Prêmio Wolf de Medicina (1995/6) Nobel de Fisiologia/Medicina (1997) Stanley Ben Prusiner Des Moines 18 de Maio de ) é um médico neurologista estadunidense Foi agraciado com o Nobel de Fisiologia/Medicina de editar Ligações externas Perfil no sítio oficial do Nobel de Fisiologia/Medicina 1997 (em inglês Precedido por Peter Doherty e Rolf Zinkernagel Nobel de Fisiologia/Medicina Sucedido por Robert Furchgott Louis Ignarro e Ferid Murad v e Prêmio Wolf de Medicina (1978 — 2008) ... Leo Sachs , Sir James L. Gowans Barbara McClintock Stanley N. Cohen Jean-Pierre Changeux ... Yasutomi Nishizuka Stanley Prusiner Mary Frances Lyon Michael Sela Ruth Arnon Eric Kandel ... Baruch Blumberg e Daniel Gajdusek Roger Guillemin Andrzej Schally e Rosalyn Yalow Werner Arber Daniel Nathans e Hamilton Smith Allan Cormack e Godfrey Hounsfield Baruj Benacerraf Jean Dausset e George Snell Roger Sperry David Hubel e Torsten Wiesel Sune Bergström Bengt Samuelsson e John Vane Barbara McClintock Niels Jerne Georges Köhler e César Milstein Michael Stuart Brown e Joseph Goldstein Stanley Cohen e Rita Levi-Montalcini Susumu Tonegawa James Black Gertrude Elion e George Hitchings John Michael Bishop e Harold Varmus Joseph Murray e Edward Donnall Thomas Erwin Neher e Bert Sakmann Edmond Fischer e Edwin Krebs Richard Roberts e Phillip Sharp Alfred Gilman e Martin Rodbell Edward Lewis Christiane Nüsslein-Volhard e

35. Giuseppe Baldwin - WikiName Ilia Baskakov research profile on BiomedExperts 2004 Baskakov Ilia V; Legname Giuseppe; Gryczynski Zygmunt; Prusiner Stanley B 2002 Baskakov Ilia V; Legname Giuseppe; Baldwin http://wiki.name.com/en/Giuseppe_Baldwin

Advanced Search Page Discussion View source ... History Giuseppe Baldwin From WikiName Previous: Giuseppe Baker Next: Surnames Gender male Giuseppe Jehovah increases, God shall add Baldwin brave, friend Pronunciation BALD-win, BALD-wen Register Giuseppe Baldwin as a domain Search Results Stanley Prusiner - research profile on BiomedExperts 2009: Bae Sung-Hun; Legname Giuseppe ; Serban Ana; Prusiner Stanley B; Wright Peter E; 2002: Baskakov Ilia V; Legname Giuseppe Baldwin Michael A; Prusiner Stanley B; Cohen Copper induces increased beta-sheet content in the scrapie Stahl N, Baldwin MA, Teplow DB, Hood L, Gibson BW, Burlingame AL, Prusiner SB. Baskakov Ilia V, Legname Giuseppe Baldwin Michael A, Prusiner Stanley B, Cohen Fred Cohen - research profile on BiomedExperts Fred Cohen - research profile on BiomedExperts:Protein Conformation, Prions, Molecular Models, Amino Acid Sequence, Secondary Protein Structure, Molecular Sequence Data. MySpace - HAHAHAAAAA - 29 - Female - - myspace.com/cennateree MySpace profile for HAHAHAAAAA with pictures, videos, personal blog, interests, information about me and more Journal of Biological Chemistry, 2002; 277 (24)

36. Prion Prusiner, Stanley B. American neurologist (1942) and winner of the Nobel Prize for the discovery of prions - a new biological principle of infection. http://health-search.closerlooksearch.com/health-topics/P/prion.html

prion: Health Search Results from the Invisible Web Definition News Further Reading Search results last updated: 9/12/2008 prion - Definition: (Source: MedicineNet Prusiner, Stanley B.: American neurologist (1942-) and winner of the Nobel Prize for the discovery of "prions - a new biological principle of infection." ... read more.. News on prion Urine test may flag mad cow disease in live cattle (ReutersHealth) Further Reading on prion Mad Cow Disease - Overview ( WebMD ) What is mad cow disease ? Mad cow disease is a fatal neurological disease that slowly destroys the brain and spinal cord ( central ...may be caused by other abnormal proteins called prions . In affected... Mad Cow Disease and Variant Creutzfeldt-Jakob Disease ( WebMD ) " Mad Cow " is an infectious disease in the brain of cattle . Humans who become infected , usually by eating tissue from diseased ...143 people with vCJD had been diagnosed in the UK. Prion disease... Beauty Today Altered Appearances ( WebMD ) Tans, tattoos, cosmetics… modern society has many ways to tweak appearance. Get an overview ...it is needed to treat critically ill patients.[39] Cow collagen may carry the prions associated with bovine...

37. Copper Binding To Octarepeat Peptides Of The Prion Protein Monitored By Mass Spe James Thomas L, Liu He, Ulyanov Nikolai B, FarrJones Shauna, Zhang Hong, Donne David G, Kaneko Kiyotoshi, Groth Darlene, Mehlhorn Ingrid, Prusiner Stanley B, Cohen Fred E http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2144551/

window.name="mainwindow"; initRedirectClicks('/pmc/extredirect/') Journal List Protein Sci v.9(2); Feb 2000 Formats: Summary PDF (620K) Protein Sci. 2000 February; PMCID: Copper binding to octarepeat peptides of the prion protein monitored by mass spectrometry. R. M. Whittal, H. L. Ball, F. E. Cohen, A. L. Burlingame, S. B. Prusiner, and M. A. Baldwin Department of Pharmaceutical Chemistry, University of California San Francisco, 94143-0446, USA. This article has been cited by other articles in PMC. Abstract Full Text The Full Text of this article is available as a PDF Selected References These references are in PubMed. This may not be the complete list of references from this article. Anderson RG, Kamen BA, Rothberg KG, Lacey SW. Potocytosis: sequestration and transport of small molecules by caveolae. Science. 1992 Jan 24; PubMed Atwood CS, Moir RD, Huang X, Scarpa RC, Bacarra NM, Romano DM, Hartshorn MA, Tanzi RE, Bush AI. Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis. J Biol Chem.

38. Prion Definition - Medical Dictionary Definitions Of Popular Medical Terms Easil Dr. Stanley B. Prusiner received the 1997 Nobel Prize in Physiology or Medicine for his discovery of prions. See also Prusiner, Stanley B.. Last Editorial Review 1/22/2004 http://www.medterms.com/script/main/art.asp?articlekey=5047

39. Removal Of Prions From Blood, Plasma And Other Liquids - Prusiner, Stanley B. Devices such as flow through columns, substrates such as spherical polymer beads, and methods of using such to remove prions from any liquid sample are disclosed. A surface of a http://www.freepatentsonline.com/y2001/0005578.html

SEARCH: GO TO ADVANCED SEARCH LOGIN: Login Create Free Account HOME SEARCH PATENTS ... HELP Removal of prions from blood, plasma and other liquids United States Patent Application 20010005578 Kind Code: Devices such as flow through columns, substrates such as spherical polymer beads, and methods of using such to remove prions from any liquid sample are disclosed. A surface of a substrate is coated with a prion complexing agent, such as a salt of phosphotungstic acid. Blood or plasma passing through a column containing beads coated with prion complexing agent are rendered prion free. Related US Applications: Flow-through assay devices Yang et al. - June, 2005 - 20050136500 COMPOSITON FOR NON-TOXIC, NON-HAZARDOUS, AND ENVIRONMENTALLY FRIENDLY HUMIDITY-INDICATING AGENT AND ITS APPLICATION Song et al. - May, 2005 - 20050106735 PLATELET RICH PLASMA FORMULATIONS FOR CARDIAC TREATMENTS Mishra - April, 2010 - 20100092444 Diagnostic assay system Ray - May, 2002 - 20020055176 Device for Collecting Blood and Separating Blood Constituents, Method for Separating Blood Constituents and Use of Said Device Blankenstein et al. - November, 2007 - 20070269893 Inventors: Prusiner, Stanley B. (San Francisco, CA, US)

40. Nobel Laureates - List Prusiner, Stanley B. San Francisco 1997 Physiology or medicine Reines, Frederick* Irvine 1995 Physics Rose, Irwin Irvine 2004 Chemistry Rowland, F. Sherwood http://www.universityofcalifornia.edu/nobel/list.html

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