21. Sakmann, Bert Sakmann, Bert (b. June 12, 1942, Stuttgart, Ger.), German medical doctor and research scientist who in 1991, together with German physicist Erwin Neher, won the Nobel Prize for http://www.uv.es/EBRIT/micro/micro_519_58.html

Britannica CD Index Articles Dictionary Help Sakmann, Bert (b. June 12, 1942, Stuttgart, Ger.), German medical doctor and research scientist who in 1991, together with German physicist Erwin Neher , won the Nobel Prize for Physiology or Medicine for research into basic cell function and for their development of the patch -clamp techniquea laboratory method widely used in cell biology and neuroscience to detect electrical currents as small as a trillionth of an ampere through cell membranes. Working together they conclusively established the existence of characteristic sets of ion channels in cell membranessome of which permit the flow of only positive ions, while others pass only negatively charged ions. This established, they examined a broad range of cellular functions, eventually discovering the role that ion channels play in such diseases as diabetes, cystic fibrosis, epilepsy, several cardiovascular diseases, and certain neuromuscular disorders. These discoveries enabled the development of new and more specific drug therapies. In 1979 Sakmann became a research associate in the Max Planck Institute's membrane biology group. He was made head of the membrane physiology unit in 1983, and he became director of the institute's department of cell physiology two years later.

22. Bert Sakmann Winner Of The 1991 Nobel Prize In Medicine Bert Sakmann, a Nobel Prize Laureate in Physiology and Medicine, at the Nobel Prize Internet Archive. http://nobelprizes.com/nobel/medicine/1991b.html

B ERT S AKMANN 1991 Nobel Laureate in Medicine for their discoveries concerning the function of single ion channels in cells. Background Born: 1942 Residence: Germany Affiliation: Max-Planck-Institut für Medizinische Forschung, Heidelberg Featured Internet Links Prize co-recipient: Erwin Neher Search WWW Search The Nobel Prize Internet Archive Nobel News Links Two Germans Win NObel Prize in Medicine for Cell Research Links added by Nobel Internet Archive visitors Max-Planck-Institut für medizinische Forschung Abteilung Zellphysiologie Winner of The Gairdner Foundation Int'l Award Bert Sakmann and his patch clamp technique (submitted by john) Bert Sakmann – Autobiography (submitted by Maikl) Bert Sakmann Biography from Encyclopedia Britannica (submitted by www.britannica.com) Bert Sakmann (submitted by Lukas) Back to The Nobel Prize Internet Archive Literature Peace Chemistry ... Medicine We always welcome your feedback and comments

23. Bert Sakmann — Infoplease.com More on Bert Sakmann from Infoplease Edwin Neher Neher, Edwin Neher, Edwin, 1944–, German biophysicist, Ph.D. Technical Univ. of Munich, 1970. http://www.infoplease.com/ce6/people/A0935443.html

24. Bert Sakmann (German Scientist) -- Britannica Online Encyclopedia Facts about Sakmann, Bert, as discussed in Britannica Compton's Encyclopedia Sakmann, Bert When was Bert Sakmann born? Where was Bert Sakmann born? http://www.britannica.com/EBchecked/topic/518742/Bert-Sakmann

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25. Chegg.com: Single-Channel Recording By | 030644870X | 9780306448706 Rent and Save a ton on SingleChannel Recording by Sakmann, Bert Neher, Erwin.ISBN 030644870X EAN 9780306448706 http://www.chegg.com/details/single-channel-recording/030644870x/

mboxCreate('TT_Global_Mbox','pageName='+window.s.pageName, 'retCust=no', 'profile.retCust=no'); Sign In Rental Cart ( CHEGG.COM Rent Textbooks ... Help FIND YOUR BOOKS FIND BOOKS SEARCH TIPS x Search Tip: The best way to find your books is by searching using ISBNs. Alternatively, you can also search using book title or author's name. But better results are returned when you put in book title and one of the authors' name together. Here are some examples of good searches: Managing Human Resources George George W. Bohlander Home Science Life Sciences Single-Channel Recording by Neher, Erwin Sakmann, Bert ISBN: EDITION: 2 Edition Type: Revised BINDING: PUBLISHER: Springer (05/31/1995) PAGES: This product is not available. SUMMARY Edited by the 1991 winners of the Nobel Prize in Physiology or Medicine, this Second Edition includes new chapters covering such applications as capacitance measurements; single-cell PCR measurements; whole-cell recording from brain slices in combination with imaging techniques; atomic force microscopy of cells and membranes attached to glass pipettes; and patch clamping. SUMMARY Edited by the 1991 winners of the Nobel Prize in Physiology or Medicine, this Second Edition includes new chapters covering such applications as capacitance measurements; single-cell PCR measurements; whole-cell recording from brain slices in combination with imaging techniques; atomic force microscopy of cells and membranes attached to glass pipet...

26. AccessScience | Biography | Sakmann, Bert The content above is only an excerpt. Please log in for full access. http://www.accessscience.com/content.aspx?id=M0047957

27. Louisa Gross Horwitz Prize For Basic Research Of Biology Or Biochemistry - Colum Columbia Awards the 2009 Horwitz Prize to RNA Biologists Victor Ambros Gary Ruvkun for their Discovery of microRNA – Critical to Gene Regulation http://www.cumc.columbia.edu/horwitz/

CUMC Home Columbia University Jobs at ... Find People Search CUMC Horwitz Home Nominate Prize Awardees Prize Committee ... Members Login Nominate a Researcher Previous Awardees F. Ulrich Hartl, M.D Arthur Horwich, M.D. Honorary Horwitz Prize Rosalind Franklin, Ph.D. Joseph G. Gall, Ph.D. Elizabeth Blackburn, Ph.D. Carol Greider, Ph. D. ... H. Robert Horvitz and Stanley J. Korsmeyer Contact us horwitzprize@columbia.edu Tel: (212)-305-7970 Each year, the Louisa Gross Horwitz Prize has been awarded by Columbia University for outstanding basic research in the fields of biology or biochemistry The purpose of this prize is to honor a scientific investigator, or group of investigators, whose contributions to knowledge in either of these fields are deemed worthy of special recognition. Previous Prize Awardees 1967 - 2008 list of Recipients of the Louisa Gross Horwitz Prize Prize Committee A panel of internationally known scientists distinguished in the fields of biology, chemistry, biochemistry and physiology. Recipients of the Horwitz Prize 2009 Victor R. Ambros, Ph.D.

28. Dr. Bert Sakmann | Research Groups | Max Planck Florida Institute Dr. Bert Sakmann INAUGURAL SCIENTIFIC DIRECTOR AND RESEARCH GROUP LEADER. Dr. Sakmann, with physicist Erwin Neher, was awarded the Nobel Prize in Medicine in 1991 for their http://www.maxplanckflorida.org/bert-sakmann.html

Research Groups About Us Research Groups Lectures Press Room ... Community Digital Neuroanatomy Dr. Bert Sakmann INAUGURAL SCIENTIFIC DIRECTOR AND RESEARCH GROUP LEADER Dr. Sakmann, with physicist Erwin Neher, was awarded the Nobel Prize in Medicine in 1991 for their discoveries on single channels in cells, enabled by their invention of the patch-clamp technique. This ground-breaking technical achievement made it possible to examine, in real time, the operation of individual ion channel proteins. Ion channels are found in the membranes of virtually all cells and create selective pores across membranes that are vital for electrical signaling. Sakmann and Neher examined a broad range of cellular functions, eventually discovering the role that ion channels play in diseases such as diabetes, cystic fibrosis, several cardiovascular diseases and certain neuromuscular disorders. This technique forged new paths in the study of membrane physiology and the creation of novel therapeutics targeting ion channels. In fact, the Nobel Prize committee credited the two scientists with revolutionizing modern biology. Research of the Digital Neuroanatomy group focuses on functional anatomy of circuits in the brain – specifically the cerebral cortex – that form the basis of simple behaviors (e.g. decision making). This research involves the use of large scale, high resolution microscopic techniques to reconstruct individual morphologies, distributions and synaptic wiring of different neuron types. Neurons are recorded from using in vivo and in vitro electrophysiological techniques. The results are used to simulate signal flow in an anatomically realistic network model. Eventually, this may reveal parts of the network that trigger sensory initiated behavior and lead to new discoveries about the brain's process of learning.

29. Sakmann, Bert Professor - School Of Biomedical Sciences Sakmann, Bert Professor. Professor Biomedical Sciences http://biomed.science.ulster.ac.uk/Sakmann-Bert-Professor.html

Contact Us E: s.cassley@ulster.ac.uk T: +44(0)28 7012 3276 F: +44(0)28 7012 4965 You are here : Ulster Homepage School of Biomedical Sciences Staff Profiles School of Biomedical Sciences Home Research Institute Pharmacy Pedagogic Research ... Publications Sakmann, Bert Professor Professor - Biomedical Sciences Publications activatables('page', ['background', 'publications']);

30. Single-Channel Recording - Sakmann, Bert - EBSCO Book Services Customer Service Customer service hours 800 AM 600 PM Central (Monday - Thursday) 800 AM - 400 PM Friday. Inside North America 1-800-815-9627 http://www.ebsco.com/eis/books/ProductDetails.asp?CatalogID=663459

31. Bert Sakmann Bert Sakmann. Born 12Jun-1942 Birthplace Stuttgart, Germany. Gender Male Race or Ethnicity White Sexual orientation Straight Occupation Scientist, Doctor http://www.nndb.com/people/861/000133462/

This is a beta version of NNDB Search: All Names Living people Dead people Band Names Book Titles Movie Titles Full Text for Bert Sakmann Born: 12-Jun Birthplace: Stuttgart, Germany Gender: Male Race or Ethnicity: White Sexual orientation: Straight Occupation: Scientist Doctor Nationality: Germany Executive summary: Cellular ion channels German physiologist Bert Sakmann won the Nobel Prize for Medicine in 1991, for describing "the function of single ion channels in cells." Working with Erwin Neher , his long-time collaborator and co-winner of Nobel honors, Sakmann invented the patch clamp, which allows observation of the minute electrical energy produced in cellular ion channels. His wife was a prominent pediatric ophthalmologist, and as Sakmann toiled in obscurity early in his career, he said he was sometimes better known as "the eye doctor's husband". Father: Bertold Sakmann (theater director) Mother: Annemarie Sakmann (physical therapist) Wife: Christiane Sakmann (ophthalmologist) High School: Wagenburg Gymnasium, Stuttgart, Germany Medical School: Medical School: University of Freiburg Medical School: University of Berlin Medical School: University of Paris Medical School: MD, University of Munich (1974)

32. Sakmann, Bert (Ger. Physiol.) Sakmann, Bert (Ger. physiol.) collaboration with Neher http://www.uv.es/EBRIT/index/index_sa_kma.html

Britannica CD Index Articles Dictionary Help Sakmann, Bert (Ger. physiol.) collaboration with Neher

33. Full Text Translator, Language Translation | Free Translations From Dictionary.c Free full text language translations at Translate.Reference.com. Free online translator and multilingual dictionary for over 50 foreign languages. http://translate.reference.com/translate?query=sakmann, bert

34. Bert Sakmann Years make the misconduct tool of rbc countries, bert sakmann. Bert sakmann, the certain school may avoid indirectly. These psychiatrists of tests not make in the board of http://utenti.multimania.it/bineruh/bert-sakmann.html

35. Single-Channel Recording By Bert Sakmann, Bert Ed. Sakmann, Erwin Neher | Flipka Flipkart.com SingleChannel Recording by Bert Sakmann Bert Ed Sakmann Erwin Neher. Rs.7717, Save 15%. Buy Single-Channel Recording, All India Free Home Delivery. 030644870X http://www.flipkart.com/single-channel-recording-bert-sakmann-book-030644870x

Home My Account Wishlist Help ... View Cart Books Music Games Mobiles The store at your door Books Single-Channel Recording (Hardcover) by Bert Sakmann (Editor) Bert Ed. Sakmann (Editor) Erwin Neher (Editor) Write a Review List Price: Rs. 8743 Our Price: Rs. 7519 (Inclusive of all taxes) Discount: Rs. 1224 off Imported Edition. Order now and get it in 14-21 business days See Details Buy online using: - Credit Card / Debit Card / Internet Banking - Cash-on-Delivery. See Details Publisher: Kluwer Academic Publishers (May 1995) OR Book Summary of Single-Channel Recording Edited by the 1991 winners of the Nobel Prize in Physiology or Medicine, this Second Edition includes new chapters covering such applications as capacitance measurements; single-cell PCR measurements; whole-cell recording from brain slices in combination with imaging techniques; atomic force microscopy of cells and membranes attached to glass pipettes; and patch clamping. top Related News for Single-Channel Recording FIRST PRESENTERS ANNOUNCED FOR "THE 44TH ANNUAL CMA AWARDS," WEDNESDAY, NOVEMBER 10 ON THE ABC TELEVISION NETWORK (October 26) Among the first wave: Luke Bryan, Easton Corbin, Little Big Town, Tim McGraw, Jerrod Niemann, Kellie Pickler, LeAnn Rimes, Darius Rucker, The Band Perry, Chris Young and Jeff Gordon.

36. Location Of A Threonine Residue In The Alpha -subunit M2 Transmembrane Segment Villarroel, Alfredo; Herlitze, Stefan; Koenen, Michael; Sakmann, Bert Publication Proceedings Biological Sciences, Volume 243, Issue 1306, pp. 6974 http://adsabs.harvard.edu/abs/1991RSPSB.243...69V

Sign on SAO/NASA ADS General Science Abstract Service Find Similar Abstracts (with default settings below Electronic Refereed Journal Article (HTML) Citations to the Article (3) Citation History ... Translate This Page Title: Location of a Threonine Residue in the alpha -subunit M2 Transmembrane Segment that Determines the Ion Flow through the Acetylcholine Receptor Channel Authors: Publication: Proceedings: Biological Sciences, Volume 243, Issue 1306, pp. 69-74 Publication Date: Origin: JSTOR Bibliographic Code: Abstract By the combination of cDNA manipulation and functional analysis of normal and mutant acetylcholine receptor (AChR) channels of Torpedo expressed in Xenopus laevis oocytes determinants of ion flow were localized in the bends bordering the putative M2 transmembrane segment (Imoto et al. 1988). We now report that in the rat muscle AChR, substitution of a threonine residue in the alpha -subunit localized in the M2 transmembrane segment increases or decreases the channel conductance, depending on the size of the amino acid side chain located at this position. This threonine residue (alpha T264) is located adjacent to the cluster of charged amino acids that form the intermediate anionic ring (Imoto et al. 1988). This effect is pronounced for the large alkali cations Cs , Rb , K whereas for Na the effect is much smaller. Taken together the results suggest that the threonine residues at position 264 in the two alpha -subunits together with the amino acids of the intermediate anionic ring form part of a narrow region close to the cytoplasmic mouth of the AChR channel.

37. Sakmann, Bert - Personenlexikon Enter your search terms Submit search form Top International Italiano Salute Medicina Medici e Ricercatori Sakmann, Bert http://www.personenlexikon.net/d/sakmann-bert/sakmann-bert.htm

Startseite Personenlexikon Thematische Gliederung Gruppen Kategorien ... Z Sakmann, Bert deutscher Mediziner, geboren 12.6.1942 Stuttgart; ab 1985 Direktor der Abteilung für Zellphysiologie des MPI-Instituts für biophysikalische Chemie in Göttingen, ab 1989 am MPI für medizinische Forschung in Heidelberg; erforschte in den 70er Jahren in Göttingen zusammen mit E. s Neher Ionenkanäle und erhielt zusammen mit Neher für die Entwicklung der patch-clamp-Methode (zur Messung der äußerst schwachen Ionenkanal-Ströme) 1991 den Nobelpreis für Physiologie oder Medizin. Diese Seite als Bookmark speichern : addthis_url = location.href; addthis_title = document.title; addthis_pub = 'woorgle1492'; Sainte-Claire Deville, Henri Étienne Salam, Abdus Weitere Begriffe : Empedokles, griechischer Naturphilosoph und Wanderarzt Buys-Ballot, Christophorus Henricus Didericus Rutherford, Ernest Personenlexikon Neuen Artikel hinzufügen Rechtliche Hinweise Impressum der Bände, »Antibiotika-Fibel« (9. sur chimiques 1832 übergegangen) (9. des Harrison, John

38. Erwin Neher: Facts, Discussion Forum, And Encyclopedia Article Landsberg am Lech is a town in southwest Bavaria, Germany, about 65 kilometers west of Munich and 35 kilometers south of Augsburg. It is the capital of the district of Landsberg am http://www.absoluteastronomy.com/topics/Erwin_Neher

Home Discussion Topics Dictionary ... Login Erwin Neher Erwin Neher Topic Home Discussion Overview Erwin Neher (born 20 March 1944 in Landsberg am Lech Landsberg am Lech Landsberg am Lech is a town in southwest Bavaria, Germany, about 65 kilometers west of Munich and 35 kilometers south of Augsburg. It is the capital of the district of Landsberg am Lech.... Bavaria Bavaria Bavaria, formally the Free State of Bavaria , is a state of Germany, located in the southeast of the country. With an area of and almost 12.5 million inhabitants, it is the largest German state by area, forming almost 20% of the total land area of Germany... ) is a German Germany Germany , officially the Federal Republic of Germany , is a country in Central Europe. It is bordered to the north by the North Sea, Denmark, and the Baltic Sea; to the east by Poland and the Czech Republic; to the south by Austria and Switzerland; and to the west by France, Luxembourg, Belgium,... biophysicist Biophysics Biophysics is an interdisciplinary science that uses the methods of physics and physical chemistry to study biological systems. Studies included under the branches of biophysics span all levels of biological organization, from the molecular scale to whole organisms and ecosystems... Erwin Neher studied physics at the Technical University of Munich Technical University of Munich The Technische Universität München is a research university with campuses in Munich, Garching, and Weihenstephan....

39. Bert Sakmann - Research Profile On BiomedExperts 2006 Hahn Thomas T G; Sakmann Bert; Mehta Mayank R Phaselocking of hippocampal interneurons' membrane potential to neocortical up-down states. http://www.biomedexperts.com/Profile.bme/1228097/Bert_Sakmann

40. Scientific Commons Otto D. Creutzfeldt An experimental comparison between the ganglion cell receptive field and the receptive field of the adaptation pool in the cat retina (1969) Sakmann,Bert http://en.scientificcommons.org/otto_d_creutzfeldt

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