21. Sharping - Hutchinson Encyclopedia Article About Sharping Sharpe, William Forsyth Sharpeville sharping Sharples, James Sharpless, K Barry Sharpness Sharpsburg Sharpton, Al, Jr Sharqiya Sharswood, George http://encyclopedia.farlex.com/sharping

22. Accelerated Catalysis Of Olefinic Epoxidations Sharpless, K. Barry; Rudolph, Joachim; Rheniumcatalyzed epoxidation of olefinic substrates is accelerated by the use http://www.devileye.net/catalog/record_grooving/accelerated_catalysis_olefinic_e

Accelerated catalysis of olefinic epoxidations Sharpless, K. Barry; Rudolph, Joachim; Rhenium-catalyzed epoxidation of olefinic substrates is accelerated by the use of acclerants having a nitrogenous aromatic heterocyclic structure. Use of the accelerants also enables the use of aqueous hydrogen peroxide as an oxidant. To achieve optimum acceleration, the accelerant should have a concentration within a range from 2.0 mole percent to 100 mole percent of the acclerant with respect to 1 mole of the olefinic substrate. Use of the accelerant also results in an increased yield with respect to the conversion of the olefinic substrate to epoxide product. TECHNICAL FIELD The present invention relates to the epoxidation of olefins. More particularly, the present invention relates to the acceleration of organorhenium catalyzed olefinic epoxidations using nitrogenous aromatic heterocycles as accelerants, hydrogen peroxide as an oxidant, and water as a solvent. BACKGROUND Many catalyzed reactions may be accelerated by the use of ligands which bind to the catalyst and enhance its catalytic activity. Ligand acceleration of catalytic transformations is a desirable phenomenon since, in addition to increasing the rate of the reaction, the ligand may also influence the selectivity features of the reaction. (Berrisford et al. Angew. Chem. 1995, 107, 1159-1171; Berrisford et al. Angew. Chem., Int. Ed. Engl. 1995, 34, 1059-1070.) Use of aqueous H.sub.2 O.sub.2 as the oxidant in transition metal-catalyzed epoxidations was first described by Venturello et al. (Venturello et al. J. Org. Chem. 1983, 48, 3831-3833; Venturello et al. J. Org. Chem. 1988, 53, 1553-1557; Prandi et al. Tetrahedron Lett. 1986, 27, 2617-2620.) Venturello disclosed the use of a tungstate catalyst under phase transfer conditions. This method is unemployable for less reactive olefins. However, Noyori recently introduced a solvent-free variation which is more effective. (Sato et al. J. Org. Chem. 1996, 61, 8310-8311.) However, the scope of the Noyori variation is limited by epoxide opening-problems caused by the slight acidity of the reaction milieu. This is a recurring problem encountered by most epoxidation methods in use today.

23. Chemists-S Sharpless, K. Barry Shirakawa, Hideki Sidgwick, Nevil Vincent Skou, Jens C. Smalley, Richard E. Smith, Michael http://www.cartage.org.lb/en/themes/Biographies/Categories/Scientists/Chemists/i

Sabatier, Paul Saint-Claire Deville, Henri Etienne Sanger, Frederick Scheele, Karl Wilhelm Sabatier, Paul Saint-Claire Deville, Henri Etienne Sanger, Frederick Scheele, Karl Wilhelm ... Synge, Richard

24. Robert Hilgraf - Research Profile On BiomedExperts 2003 Wang Qian; Chan Timothy R; Hilgraf Robert; Fokin Valery V; Sharpless K Barry; Finn M G Bioconjugation by copper(I)catalyzed azide-alkyne 3 + 2 cycloaddition. http://www.biomedexperts.com/Profile.bme/563185/Robert_Hilgraf

25. MIT Office Of The Provost, Institutional Research Sharpless, K. Barry 2001 Chemistry (shared) Townes, Charles H. 1964 Physics (shared) Weinberg, Steven 1979 Physics (shared) Staff Former 14 Barton, Derek - Visiting Faculty http://web.mit.edu/ir/pop/awards/nobel.html

Nobel Prize Nobel Foundation Royal Swedish Academy of Sciences Awards and Honors Home Institutional Research Staff Home View by Relationship View by Discipline View by Year Faculty - Current: 9 Diamond, Peter A. Economic Sciences (shared) Horvitz, H. Robert Medicine/Physiology (shared) Ketterle, Wolfgang Physics (shared) Merton, Robert C.* Economic Sciences (shared) Schrock, Richard R. Chemistry (shared) Sharp, Phillip A. Medicine/Physiology (shared) Ting, Samuel C. C. Physics (shared) Tonegawa, Susumu Medicine/Physiology Wilczek, Frank Physics (shared) MIT Alumni: 20 Akerlof, George A. Economic Sciences (shared) Altman, Sidney Chemistry (shared) Annan, Kofi Peace (shared) Aumann, Robert Economic Sciences (shared) Corey, Jr., Elias J. Chemistry Cornell, Eric A. Physics (shared) Fire, Andrew Medicine/Physiology (shared) Gell-Mann, Murray Physics Hao, Wei M. Peace (one of 13 U.S. Forest Service researchers recognized under Intergovernmental Panel on Climate Change (IPCC) - shared) Hartwell, Leland H. Medicine/Physiology (shared) Klein, Lawrence R. Economic Sciences Laughlin, Robert B.

26. MIT Office Of The Provost, Institutional Research Sharpless, K. Barry 2001 Whitesides, George M. 2009 Staff Former 2 St rmer, Horst L. 1998 shared with Daniel C. Tsui Tsui, Daniel C. 1998 shared with Horst L. Stormer http://mit.edu/ir/pop/awards/franklin.html

Franklin Institute Awards Franklin Institute Awards and Honors Home Institutional Research Staff Home Benjamin Franklin Medal Faculty - Current: 4 Goldwasser, Shafrira Guth, Alan H. Ketterle, Wolfgang Stubbe, JoAnne MIT Alumni: 1 Widrow, Bernard Faculty - Emeritus: 4 Biemann, Klaus Chomsky, Noam Flemings, Merton C. Minsky, Marvin L. Faculty - Former: 2 Sharpless, K. Barry Whitesides, George M. Staff - Former: 2 shared with Daniel C. Tsui Tsui, Daniel C. shared with Horst L. Stormer Benjamin Franklin Medal total: 13 List generated 10-20-2010 Bower Award Faculty - Current: 1 Rich, Alexander MIT Alumni: 1 Jacobs, Irwin M. Faculty - Former: 1 Cahn, John W. Bower Award total: 3 List generated 10-20-2010 Institutional Research Office of the Provost Massachusetts Institute of Technology 77 Massachusetts Avenue, Room 11-268 Cambridge, MA 02139-4307 617.258.5876 phone 617.253.1986 fax

27. K. Barry Sharpless: Facts, Discussion Forum, And Encyclopedia Article A chemist is a scientist trained in the science of chemistry. Chemists study the composition of matter and its properties such as density, acidity, size and shape. http://www.absoluteastronomy.com/topics/K._Barry_Sharpless

Home Discussion Topics Dictionary ... Login K. Barry Sharpless K. Barry Sharpless Topic Home Discussion Quotations Overview Karl Barry Sharpless (born 28 April 1941) is an American chemist Chemist A chemist is a scientist trained in the science of chemistry. Chemists study the composition of matter and its properties such as density, acidity, size and shape. Chemists carefully describe the properties they study in terms of quantities, with detail on the level of molecules and their component... known for his work on stereoselective reactions. Sharpless was born in Philadelphia. He graduated from Friends' Central School Friends' Central School Friends' Central School is a Religious Society of Friends school located in Wynnewood, a section of Lower Merion Township, Pennsylvania, United States... in 1959. He continued his studies at Dartmouth College Dartmouth College Dartmouth College is a private, coeducational university, comprising a liberal arts college, Dartmouth Medical School, Thayer School of Engineering, and Tuck School of Business, as well as 19 graduate programs in the arts and sciences.. It is located in Hanover, New Hampshire... (1963) and earned his Ph.D from

28. 1,5-Cyclooctadiene - Wikipedia, The Free Encyclopedia nonane2,6-dione , Org. Synth., http//www.orgsyn.org/orgsyn/orgsyn/prepContent.asp?prep=CV9P0692 ; Coll. Vol. 9 692 D az, David D az; Converso, Antonella; Sharpless, K. Barry http://en.wikipedia.org/wiki/1,5-Cyclooctadiene

1,5-Cyclooctadiene From Wikipedia, the free encyclopedia Jump to: navigation search 1,5-Cyclooctadiene Identifiers CAS number Y ChemSpider Y EC-number SMILES InChI InChI=1/C8H12/c1-2-4-6-8-7-5-3-1/h1-2,7-8H,3-6H2/b2-1-,8-7- InChI key VYXHVRARDIDEHS-QGTKBVGQSA-N VYXHVRARDIDEHS-QGTKBVGQBM Properties Molecular formula C H Molar mass 108.18 g/mol Appearance clear colorless liquid Density 0.882 g/ml, liquid Melting point -69.5 °C Boiling point 151 °C Solubility in water Y (what is this?) (verify) Except where noted otherwise, data are given for materials in their Infobox references 1,5-Cyclooctadiene is the organic compound with the chemical formula C H . Generally abbreviated COD, this diene is a useful precursor to other organic compounds and serves as a ligand in organometallic chemistry Contents Synthesis Reactions and applications Organic reactions Metal complexes ... edit Synthesis 1,5-Cyclooctadiene can be prepared by dimerization of butadiene in the presence of a nickel catalyst, a coproduct being vinylcyclohexene. Approximately 10,000 tons were produced in 2005. edit Reactions and applications edit Organic reactions COD reacts with borane to give 9-borabicyclo[3.3.1]nonane

29. CAS Science Spotlight Most Requested Journal Articles 1Q04-Chemistry And Related Kolb, Hartmuth C.; Sharpless, K. Barry Department of Chemistry, The Scripps Research Institute, La Jolla, CA, 92037, USA Drug Discovery Today http://www.cas.org/spotlight/rlist1q04j/rlist1q04j.html

CAS Journals ACS Home ... Sign up to receive notice of future updates. Home Spotlight Most Requested Journal Articles 1Q04-Chemistry and Related Listed below are the chemistry and related science journal articles which researchers have most frequently requested while using CAS electronic products (SciFinder, SciFinder Scholar, STN, and CA on CD). This is a list of the journal articles most requested during 1Q2004. Title Author/Affiliation Source 1. Suzuki Cross-Couplings of Unactivated Secondary Alkyl Bromides and Iodides [details] Zhou, Jianrong; Fu, Gregory C. Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA J. Am. Chem. Soc. American Chemical Society 2. The growing impact of click chemistry on drug discovery [details] Kolb, Hartmuth C.; Sharpless, K. Barry Department of Chemistry, The Scripps Research Institute, La Jolla, CA, 92037, USA Drug Discovery Today Elsevier Science Ltd. 3. Advances in biomaterials, drug delivery, and bionanotechnology [details] Langer, Robert; Peppas, Nicholas A. Dept. of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA

30. (WO/2007/011967) METHOD OF USING CLICK CHEMISTRY TO FUNCTIONALIZE SHARPLESS, K., Barry US/US; (US) (US Only). Inventors WU, Peng; (US). FOKIN, Valery; (US). SHARPLESS, K., Barry; (US). Agent FITTING, Thomas et al.; THE SCRIPPS RESEARCH http://www.wipo.int/pctdb/en/wo.jsp?wo=2007011967

31. Sharpish - Definition Of Sharpish By The Free Online Dictionary, Thesaurus And E Sharpless, K Barry Sharpling sharply sharply sharply sharply sharply sharply sharply defined sharpness sharpness sharpness sharpness sharpness sharpness Sharpness (visual) http://www.thefreedictionary.com/sharpish

32. The Scripps Research Institute Sharpless, K. Barry discovers new and useful transformations for organic synthesis, particularly employing inorganic catalysts and olefinderived compounds of high reactivity; he http://www.scripps.edu/research/fac_int_list.php?int_id=48&interest=HIV/AIDS

33. Iterative In Situ Click Chemistry Creates Antibody-like Protein-capture Agents - Nag, Arundhati and Yeo, WoonSeok and Hein, Jason E. and Pitram, Suresh M. and Tariq, Abdul Ahad and Burns, Vanessa M. and Krom, Russell J. and Fokin, Valery V. and Sharpless, K. Barry and http://resolver.caltech.edu/CaltechAUTHORS:20090804-133827150

@import url(http://authors.library.caltech.edu/style/auto.css); @import url(http://authors.library.caltech.edu/style/print.css); @import url(http://authors.library.caltech.edu/style/nojs.css); CaltechAUTHORS A Caltech Library Service Home About ... Create Account Iterative in situ click chemistry creates antibody-like protein-capture agents Agnew, Heather D. and Rohde, Rosemary D. and Millward, Steven W. and Nag, Arundhati and Yeo, Woon-Seok and Hein, Jason E. and Pitram, Suresh M. and Tariq, Abdul Ahad and Burns, Vanessa M. and Krom, Russell J. and Fokin, Valery V. and Sharpless, K. Barry and Heath, James R. Iterative in situ click chemistry creates antibody-like protein-capture agents. Angewandte Chemie International Edition, 48 (27). pp. 4944-4948. ISSN 1433-7851 http://resolver.caltech.edu/CaltechAUTHORS:20090804-133827150 PDF - Published Version Restricted to Repository administrators only See Usage Policy. PDF - Supplemental Material Restricted to Repository administrators only See Usage Policy. Use this Persistent URL to link to this item: http://resolver.caltech.edu/CaltechAUTHORS:20090804-133827150

34. On Water Reaction: Facts, Discussion Forum, And Encyclopedia Article Organic reactions are chemical reactions involving organic compounds. The basic organic chemistry reaction types are addition reactions, elimination reactions, substitution http://www.absoluteastronomy.com/topics/On_water_reaction

Home Discussion Topics Dictionary ... Login On water reaction On water reaction Topic Home Discussion Overview On water reactions are a group of organic reaction Organic reaction Organic reactions are chemical reactions involving organic compounds. The basic organic chemistry reaction types are addition reactions, elimination reactions, substitution reactions, pericyclic reactions, rearrangement reactions and redox reactions. In organic synthesis, organic reactions are used... s that take place as an emulsion Emulsion An emulsion is a mixture of two or more immiscible liquids. Emulsions are part of a more general class of two-phase systems of matter called colloids. Although the terms colloid and emulsion are sometimes used interchangeably, emulsion tends to imply that both the dispersed and the continuous... in water and that exhibit an unusual reaction rate Reaction rate The reaction rate or rate of reaction for a reactant or product in a particular reaction is intuitively defined as how fast a reaction takes place... acceleration compared to the same reaction in an organic solvent or compared to the corresponding dry media reaction Dry media reaction A dry media reaction or solid-state reaction or solventless reaction is a chemical reaction system in the absence of a solvent. The drive for the development of dry media reactions in chemistry is* economics...

35. MIT Office Of The Provost, Institutional Research Sharpless, K. Barry 2001 Whitesides, George M. 2009 Staff Former 2 St rmer, Horst L. 1998 shared with Daniel C. Tsui Tsui, Daniel C. 1998 shared with Horst L. Stormer http://web.mit.edu/ir/pop/awards/franklin.html

Franklin Institute Awards Franklin Institute Awards and Honors Home Institutional Research Staff Home Benjamin Franklin Medal Faculty - Current: 4 Goldwasser, Shafrira Guth, Alan H. Ketterle, Wolfgang Stubbe, JoAnne MIT Alumni: 1 Widrow, Bernard Faculty - Emeritus: 4 Biemann, Klaus Chomsky, Noam Flemings, Merton C. Minsky, Marvin L. Faculty - Former: 2 Sharpless, K. Barry Whitesides, George M. Staff - Former: 2 shared with Daniel C. Tsui Tsui, Daniel C. shared with Horst L. Stormer Benjamin Franklin Medal total: 13 List generated 10-20-2010 Bower Award Faculty - Current: 1 Rich, Alexander MIT Alumni: 1 Jacobs, Irwin M. Faculty - Former: 1 Cahn, John W. Bower Award total: 3 List generated 10-20-2010 Institutional Research Office of the Provost Massachusetts Institute of Technology 77 Massachusetts Avenue, Room 11-268 Cambridge, MA 02139-4307 617.258.5876 phone 617.253.1986 fax

36. Archive Of Famous Organic Chemists Sharpless, K. Barry (1941; USA) Stanford; Sheehan, John C. (1915; USA) Michigan; with Bachmann http://orgchem.chem.uconn.edu/colleges/oldchemists.html

An Archive of Famous Organic Chemists Return to the Intercollegiate Site A total of people have accessed this page since April 7, 1998. Click here to add a name or make a comment. A B C D ... Z Name (birth - death; country) [Ph.D. granting school; thesis advisor] A Adams, Roger (1889-1971; USA) [Harvard; with Torrey, Richards] Adkins, Homer (1892-1949; USA) [Ohio State; with Evans] Alder, Kurt (1902-1958; Germany) [Kiel; with Diels] Arigoni, Duilio (; Switzerland) [ETH; -] Arndt, Fritz (1885-; Germany) [Freiburg; with Howitz] Arrhenius, Svanate (1859-1927; ) [; ] Auwers, Karl von (1863-1939; Germany) [Berlin; with Hofmann] Avogadro, Amadeo (1776-1856; Italian) [; ] B Bader, Alfred R. (1924-; Austria/USA) [Harvard; with Fieser] Baeyer, Adolph von (1835-1917; Germany) [; ] Bamberger, Eugen (1857-1932; Germany) [Berlin; with Liebermann]

37. CAS Science Spotlight Most Requested Journal Articles 2004-Chemistry And Related Kolb, Hartmuth C.; Sharpless, K. Barry CORPORATE SOURCE Department of Chemistry, The Scripps Research Institute, La Jolla, CA, 92037, USA SOURCE http://www.cas.org/spotlight/rlist2004j/200502j2.html

CAS Journals ACS Home ... Spotlight Most Requested Journal Articles 2004-Chemistry and Related (2) Most Requested Journal Articles 2004-Chemistry and Related Following is one of the journal articles most requested by researchers using CAS online services. CAS indexed 1 chemical substance from this document. CAS subject entries for this document include: Combinatorial chemistry; Combinatorial library; Drug design; and 3 additional concepts TITLE: The growing impact of click chemistry on drug discovery AUTHOR(S): Kolb, Hartmuth C.; Sharpless, K. Barry CORPORATE SOURCE: Department of Chemistry, The Scripps Research Institute, La Jolla, CA, 92037, USA SOURCE: Drug Discovery Today (2003), 8(24), 1128-1137 CODEN: DDTOFS; ISSN: 1359-6446 PUBLISHER: Elsevier Science Ltd. LANGUAGE: English ABSTRACT: A review. Click chem. is a modular approach that uses only the most practical and reliable chem. transformations. Its applications are increasingly found in all aspects of drug discovery, ranging from lead finding through combinatorial chem. and target-templated in situ chem., to proteomics and DNA research, using bioconjugation reactions. The copper-(I)-catalyzed 1,2,3-triazole formation from azides and terminal acetylenes is a particularly powerful linking reaction, due to its high degree of dependability, complete specificity, and the bio-compatibility of the reactants. The triazole products are more than just passive linkers; they readily assoc. with biol. targets, through hydrogen bonding and dipole interactions. Click chem., a modular approach based on highly reliable chem. transformations, is being applied in all aspects of drug discovery, ranging from lead finding to proteomics and DNA research.

38. Aziridination Of Olefins - US Patent 5929252 Claims Sharpless, K. Barry; Jeong, Jae Uk; Application No. 097845 filed on 06/15/1998 . US Classes 548/968, Chalcogen attached indirectly to the hetero ring by nonionic bonding 548/969 The three http://www.patentstorm.us/patents/5929252/claims.html

39. Cyclic Sulfate Compounds - US Patent 5023342 Claims Sharpless, K. Barry; Gao, Yun; Assignee. Massachusetts Institute of Technology; Application No. 199157 filed on 05/26/1988 . US Classes 549/34, Three or more ring hetero atoms in the hetero http://www.patentstorm.us/patents/5023342/claims.html

40. Www.nature.com AU Sharpless, K Barry. AU - Omura, Satoshi. TI - Chitinase inhibitors extraction of the active framework from natural argifin and use of in situ click chemistry http://www.nature.com/ja/journal/v62/n5/ris/ja200928a.ris

Content-type: text/application/x-research-info-systems TY - JOUR AU - Hirose, Tomoyasu AU - Sunazuka, Toshiaki AU - Sugawara, Akihiro AU - Endo, Ayako AU - Iguchi, Kanami AU - Yamamoto, Tsuyoshi AU - Ui, Hideaki AU - Shiomi, Kazuro AU - Watanabe, Takeshi AU - Sharpless, K Barry AU - Omura, Satoshi TI - Chitinase inhibitors: extraction of the active framework from natural argifin and use of in situ click chemistry JA - J Antibiot PY - 2009/03/27/online VL - 62 IS - 5 SP - 277 EP - 282 PB - Japan Antibiotics Research Association SN - 0021-8820 UR - http://dx.doi.org/10.1038/ja.2009.28 L3 - http://www.nature.com/ja/journal/v62/n5/suppinfo/ja200928s1.html ER -

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