41. Willkommen Bei Öko-Recherche Analyses of material flows of chemicals in the environment, including endocrine-disrupting industrial chemicals. Site in English and German. Flags are language selectors. http://www.oekorecherche.de/

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42. Endocrine Disruptors State Activity Page Endocrine disruptors or EDCs (endocrine disrupting chemicals) are external agents that interfere in some way with the role of natural http://www.serconline.org/endoDisrupt.html

Home State Info Innovative Legislation ISSUE: ENDOCRINE DISRUPTORS Center for Bioenvironmental Research at Tulane and Xavier Universities: e.hormone Medical Research Council: Institute for Environment and Health: REDIPED (Relational Database of Information on Potential Endocrine Disrupters) Atrazine One known endocrine disruptor, atrazine, has been the subject of numerous studies documenting its effects on wildlife and humans. According to a press release issued on August 20, 2003 by the Natural Resources Defense Council (NRDC): Even though atrazine has been banned in several European countries, the EPA has been reluctant to determine the full danger it presents. In another press release study file suit against the EPA in August 2003 for failing to consider the implications of atrazine on endangered wildlife. Background Decline in sperm quality Male reproductive abnormalities Early puberty Decline in neurological functions Cancers, including breast, endometrial, testicular, prostate, and thyroid

43. Endocrine Disrupters Information from the Why Files about the endocrine system, effects of pesticides/PCBs/dioxins on wildlife and people, and prospects for action to resolve this concern. http://whyfiles.org/045env_hormone/

In July, an EPA committee met in Chicago. Their problem: are synthetic chemicals causing hormonal chaos? [Posted August 7, 1997] Wildlife woes : Pesticides don't discriminate Human woes : DES, DDT, PCB's, dioxin 'n more Hormone basics Hormone confusion : How disrupters do their work History : DDT and eagles' eggs The EPA's action plan Prospects for success There are documents. Bibliography Credits Search

44. Endocrine Disruptors: Characteristics The endocrine system is a complex communication system between chemical signals and their targets responsible for regulating internal functions of the body (for more info see http http://enhs.umn.edu/current/5103/endocrine/character.html

Endocrine Disruptors Characteristics Fate and Transport in the Environment Methods for Monitoring in the Environment Methods for Measuring Human ... 5103/5104 Home What are endocrine disruptors? The endocrine system is a complex communication system between chemical signals and their targets responsible for regulating internal functions of the body (for more info see http://www.emc.maricopa.edu/faculty/farabee/BIOBK/BioBookENDOCR.html). 1. By mimicking the sex steroid hormones estrogen and androgen by binding to their natural receptors either as agonists or antagonists. 2. By altering the synthesis and breakdown of natural hormones. 3. By modifying the production and functioning of hormone receptors. In general, compounds that mimic estrogens are termed environmental estrogens whereas compounds that block hormone action are termed anti-estrogens or anti-androgens (male sex hormone). Environmental estrogens have been the focus of the majority of research on endocrine disruptors. This includes, but is not limited to chemicals that mimic the female sex hormone estradiol-17b. Chemical structures of EDCs Interestingly, the chemical structures of natural hormones and environmental hormones are most often very different. It is not possible to determine whether a chemical is an endocrine disruptor or not by merely looking at its chemical structure. Because the structures of endocrine disruptors are so variable and unpredictable, they are sometimes synthesized unintentionally. A couple examples include the pesticide DDT and polychlorinated biphenyls (PCBs), both of which have estrogenic activity, but were originally synthesized for a completely unrelated purpose. The figure below demonstrates the structural diversity of chemicals in the environment reported to be estrogenic (1).

45. Fox River Watch Provides information on the PCB pollution of the Fox River, Green Bay, Wisconsin and Lake Michigan including research on PCBs, history, health effects, toxicity, sediment remediation, dredging, cleanup, and politics. http://www.foxriverwatch.com/

PCB contamination of the Fox River, Green Bay, and Lake Michigan is a health risk and requires cleanup. Fox River Watch How YOU Can Help Frequently Asked Questions ... Maps of the PCB Contaminated Area Why is PCB Cleanup Needed? Human Health Risks Wildlife Health Risks Economic Damages Actions Proposed Sediment Cleanup (Superfund) PCB Cleanup Technologies Government Involvement State Federal Local Governments Technical Assistance Grant (TAG) Comments by TAG Project Experts: Dr. Peter deFur, Consultant Dr. Jeffrey Foran, Toxicologist Donna Boreck, Geologist William G. Acker, Engineer ... Political Cartoons Newsletter articles by Clean Water Action Council on Fox River Cleanup and Paper Mills Join our discussion of current events Health Research News: Breast Cancer Risks Due to Fish Eating PCBs change boy/girl behavior PCBs add to sun cancer risk Pollutants may produce more boys ... PCB Chemistry, "Those who eat fish from lower Green Bay and below the DePere Dam face a cancer risk due to PCBs equal to smoking 2 to 3 packs of cigarettes a day." Dr. Jeffery Foran, toxicologist

46. Endocrine Disrupting Pesticides Endocrine disrupting pesticides Many pesticides are now suspected of being endocrine disruptors chemicals that can lead to an increase in birth defects, sexual abnormalities and http://www.pan-uk.org/pestnews/Actives/endocrin.htm

Endocrine disrupting pesticides Many pesticides are now suspected of being endocrine disruptors - chemicals that can lead to an increase in birth defects, sexual abnormalities and reproductive failure. Gwynne Lyons of WWF-UK examines the current evidence and potential for adverse effects to occur in both wildlife and human populations. Endocrine disrupting chemicals (EDCs) are substances that can cause adverse effects by interfering in some way with the body's hormones or chemical messengers. These substances are therefore called hormone disruptors or endocrine disruptors, as it is the endocrine glands that secrete the hormones. Hormones play a crucial role in guiding normal cell differentiation in early life forms, and so exposure to endocrine disrupting substances in the egg or in the womb can alter the normal process of development. Mature animals can also be affected, but it is the developing organism that is especially vulnerable. Exposure at this sensitive time may cause effects that are not evident until later in life, such as effects on learning ability, behaviour, reproduction and increased susceptibility to cancer and other diseases. Effects of EDCs The effects that can be seen in an organism exposed to an endocrine disrupting chemical (EDC) depend on which hormone system is targeted. For example, if an organism is exposed to sex hormone disrupting pesticides in the womb, then the sort of effects that may be evident include effects on sexual behaviour, structural deformities of the reproductive tract, including intersex type conditions and undescended testes, deficits in sperm counts, and effects on sex ratios. However, if the primary action is on the thyroid hormones, then as these hormones are responsible for metabolism and normal brain development, exposure in the womb may cause effects on intelligence and growth. Laboratory tests have confirmed that endocrine disrupting chemicals do indeed cause such effects in exposed animals, but all the effects listed above have also been noted in wildlife or humans heavily exposed to endocrine disrupting pesticides or industrial chemicals.

47. Hormonally Active Agents In The Environment 1999 National Academy of Sciences report (1) examines the science behind the ominous prospect of estrogen mimics threatening health and well-being and (2) identifies research needs. Purchase book or read it online. http://www.nap.edu/catalog/6029.html

48. 'Endocrine Disruptor' Won't Be On Label - USATODAY.com But it doesn't require companies to study whether products contain chemicals such as endocrine disruptors. These chemicals — which include preservatives called parabens that are http://www.usatoday.com/news/health/2007-10-30-endocrine-main_N.htm

49. Introduction To Hormone Disrupting Chemicals An introduction to the effects of hormone disrupting chemicals on man and the environment, and the response of governments and industry to this problem. Written for anyone interested in the subject. Includes internet links and other references. http://website.lineone.net/~mwarhurst

Home Health concerns Suspect chemicals The endocrine system Issues ... About this site Introduction to Hormone Disrupting Chemicals These pages provide an introduction to the effects of hormone disrupting chemicals on man and the environment, and the response of Governments and industry to this problem. Other terms used to describe these chemicals include xenoestrogens, oestrogenic (estrogenic), hormone mimicking and endocrine disrupting chemicals. These pages are aimed at anyone interested in the subject, and include references to other research and reviews for those interested in investigating the field further. 1) Revised links This site has not been updated for some years. If you want to know what is happening now with chemicals policy in Europe, try the following sites: ChemTrust Greenpeace European Unit - Chemicals Chemicals Health Monitor Project International Chemicals Secretariat The " substitute it now " campaign against the worst chemicals WWF's European Policy Office - Chemicals 2) A new blog on European Environmental Policy In July 2009 I started a new personal internet project (the first since this web site), a blog on European Envronmental Policy, find out more at:

50. OSH Answers: Endocrine Disruptors What is the endocrine system? What are some examples of hormones? Why should we be concerned about the endocrine system? http://www.ccohs.ca/oshanswers/chemicals/endocrine.html

@import url(/css/base2.css); Canadian Centre for Occupational Health and Safety www.ccohs.ca Skip to content Common menu bar links Home Contact Us Help Search ... OSH Answers Institutional links CCOHS About CCOHS Newsroom Web Information Service OSH Answers ... Where are endocrine disruptors often found and what are examples? What is the endocrine system? The endocrine system is comprised of a number of glands in the body that do not have ducts and other similar structures. Glands in the endocrine system include the ovaries; the testes; the thyroid, parathyroid, adrenal, and pituitary glands; the pineal body; the pancreas; as well as cells of the gastrointestinal tract, and the placenta. What distinguishes endocrine glands from other glands is that endocrine glands secrete certain chemical called hormones and other glands produce other chemicals or fluids; for example, lacrimal glands secrete tears, salivary glands produce saliva, and sweat glands produce sweat. Hormones (so-called "chemical messengers") produced by endocrine glands enter the capillaries (and lymph vessels) of the blood circulatory system. They travel through the bloodstream to specific "receptors" in target organs or systems where they can trigger their biological effects. The endocrine system is important because it coordinates and regulates many essential body functions such as growth and maturation;

51. Welcome IPEN IPEN works for the global elimination of persistent organic pollutants. Information on PCBs (polychlorinated biphenyls) including health effects, international, national and local policy efforts, elimination technology, and links to further research and resources. http://www.ipen.org/

Welcome to the International POPs Elimination Network: "IPEN is a unique global network of people and public interest organizations, which respects and enjoys a wide diversity of cultures, skills and knowledge. Together we share a common commitment to achieve a toxic-free future where chemical production, use and disposal does not harm people and the environment. We welcome you to the IPEN family to work together for the elimination of the world's toxic legacy and to ensure safe alternatives for the protection of all living things and the prevention of future contamination world wide." Co-chairs: Dr. Mariann Lloyd-Smith. Dr. Olga Speranskaya. New to the Issues? See the Movie View a 6 minute movie about IPEN and the threat of POPs International POPs Projects Learn from examples of NGO POPs Projects on the Ground. What Are POPs? Read about the impacts of the chemicals called persistent organic polluants or POPs. What is the Stockholm Convention? Read about the Stockholm Convention and how it protects us all from POPs. Envisioning a Toxics-Free Future Read how IPEN groups all over the world are working for a toxics free future.

52. Endocrine Disruptors: 1. What Are Endocrine Disruptors (EDCs)? The endocrine system is a set of glands and the hormones they produce, which help guide the development, growth, reproduction, and behaviour of animals and humans. Some http://www.greenfacts.org/en/endocrine-disruptors/l-2/endocrine-disruptors-1.htm

Publications Blog About us Press Room ... Links Languages: English [en] Español [es] Français [fr] Home Endocrine Disruptors Level 2 » Question 1 Source document: IPCS GreenFacts (2004) Scientific Facts on Endocrine Disruptors Information on our Three-Level Structure Level 2 Questions Next Question Level 1: ... Next Sub-Question 1. What are Endocrine Disruptors (EDCs)? 1.1 What is the endocrine system? What is the definition of endocrine disruptors? Why is there concern about endocrine disruptors? 1.1 What is the endocrine system? The endocrine system is a complex system consisting of glands in the body that produce hormones . Examples are the thyroid gland in the throat, the pituitary gland in the brain, the adrenals , pancreas and ovaries in the abdomen, and the testicles, which lie outside the abdomen. Hormones act as chemical messengers, controlling many basic functions, such as growth, development, reproduction, how food is utilised in the body, blood pressure, blood glucose levels and fluid balance. Examples of hormones are insulin from the pancreas, which controls blood glucose, and the sex hormones, oestrogen from the ovary and testosterone from the testicles, which affect reproductive function. Hormones are carried in the blood stream to distant target organs or cells where they perform particular functions. Examples are the

53. NTP: Center For The Evaluation Of Risks To Human Reproduction (CERHR) Resource for the latest information about potentially hazardous effects of chemicals on human reproduction and development. http://cerhr.niehs.nih.gov/

Skip to Page Content Skip to Main Navigation Search the CERHR Website National Toxicology Program Home Testing Information Public Health ... Help The NTP-CERHR Draft NTP Brief on Soy Infant Formula (available March 16, 2010) to be reviewed at the NTP Board of Scientific Counselors (BSC) meeting on May 10, 2010 (See Federal Register Notice The NTP-CERHR announces the availability of the Expert Panel Report on Soy Infant Formula (January 15, 2010) and request for comments Federal Register The NTP-CERHR announces plans for updated evaluations of Soy Formula and requests public comments and nomination of Expert Panel Members; see October 2, 2008 Federal Register Federal Register Notices Press Releases CERHR Home ... Español Welcome! The Center for the Evaluation of Risks to Human Reproduction (CERHR) web site is your resource for the latest information about potentially hazardous effects of chemicals on human reproduction and development. Back to Top Page last updated on 01/17/2007 Home Testing Information Public Health About the NTP ... Inspector General For questions, comments, and suggestions: Contact Us

54. Weed Killer Deforms Frogs In Sex Organs, Study Finds - New York Times New York Times report on University of California study that found that male frogs exposed to very low doses of atrazine are deficient in testosterone and can develop multiple sex organs. http://www.nytimes.com/2002/04/17/science/17FROG.html

Home Page Today's Paper Video Most Popular ... Login Search All NYTimes.com Archives COLLECTIONS ATRAZINE Weed Killer Deforms Frogs In Sex Organs, Study Finds Published: April 17, 2002 WASHINGTON, April 16 — Male frogs exposed to very low doses of a common weed killer can develop multiple sex organs, sometimes both male and female, researchers in California have discovered. The weed killer, atrazine, is the most commonly used one in North America and can be found in rainwater, snow runoff and ground water, said Tyrone B. Hayes of the University of California, who led the research. ''There is virtually no atrazine-free environment,'' Dr. Hayes said. The Environmental Protection Agency permits up to three parts per billion of atrazine in drinking water. The University of California team found it affected frogs at doses as small as 0.1 part per billion. As the amount of atrazine increased, as many as 20 percent of frogs exposed during their early development produced multiple sex organs or had both male and female organs. Many had small, feminized larynxes. The research is reported today in The Proceedings of the National Academy of Science.

55. NRDC: Atrazine: Poisoning The Well NRDC website describes research suggesting the atrazine is a carcinogen and causes sexual abnormalities in male frogs. http://www.nrdc.org/health/pesticides/natrazine.asp

@import url(/stylesheets/frame.css); @import url(/stylesheets/main.css); @import url(/stylesheets/oneoffs/col-left-rightborder.css); @import url(/stylesheets/oneoffs/file-4584.css); @import url(/stylesheets/lightwindow.css); @import url(/stylesheets/print.css); Skip to main content NRDC gets top ratings from the charity watchdogs About Us News ... Take Action NRDC's mission is to safeguard the Earth: its people, its plants and animals and the natural systems on which all life depends. In this Section Main Page Global Warming Energy Air ... All Health Documents Atrazine: Poisoning the Well Atrazine Continues to Contaminate Surface Water and Drinking Water in the United States Banned in the European Union and clearly linked to harm to wildlife and potentially to humans, the pesticide atrazine provides little benefit to offset its risks. In 2009, NRDC analyzed results of surface water and drinking water monitoring data for atrazine and found pervasive contamination of watersheds and drinking water systems across the Midwest and Southern United States. This May 2010 report summarizes scientific information that has emerged since the publication of our initial report and includes more recent monitoring data. Approximately 75 percent of stream water and about 40 percent of all groundwater samples from agricultural areas tested in an extensive U.S. Geological Survey study contained atrazine. NRDC found that the U.S. EPA's inadequate monitoring systems and weak regulations have compounded the problem, allowing levels of atrazine in watersheds and drinking water to peak at extremely high concentrations.

56. Endocrine Disruptors: Preventing Or Controlling Exposure The following is a brief outline of legislation and activities surrounding the process of understanding the impact of endocrine disruptors in the environment. http://enhs.umn.edu/current/5103/endocrine/prevent.html

Endocrine Disruptors Characteristics Fate and Transport in the Environment Methods for Monitoring in the Environment Methods for Measuring Human ... 5103/5104 Home Strategies For Preventing or Controlling Exposure The following is a brief outline of legislation and activities surrounding the process of understanding the impact of endocrine disruptors in the environment. As is shown, the serious study of EDCs is barely a decade old. The progress highlights the current lack of knowledge about the nature of EDCs and the level of exposure required to effect human health. According to the Executive Summary of Endocrine Active Substances written by Junshi Miyamota and Joanna Burger one of the main questions facing scientists and policy makers is when is there enough scientific understanding to proceed with actions. 1972 - Clean Water Act (CWA) regulates toxic water pollutants. 1974 - Safe Drinking Water Act (SDWA) sets enforceable maximum contaminant levels for certain substances in drinking water such as pesticides, non-pesticide organics, and inorganic chemicals that are suspected endocrine disruptors. 1995 - The NSTC Committee on Environment and Natural Resources (CENR) identified endocrine disruptors as an initiative.

57. Welcome This conservative, industry/government funded site provides very cautious interpretations of scientific findings about endocrine disruption. http://www.emcom.ca/welcome/index.shtml

the information site on endocrine disruption Welcome to provides up-to-date authoritative information on endocrine modulation and endocrine disruptors and offers scientifically based opinion on reproductive and developmental health outcomes in humans including breast cancer endometrial cancer endometriosis fecundity and fertility ... thyroid hormones and immune system Our site has been organized in various layers that provide easy-to-understand information for the non-expert public about environmental estrogens and hormonally active agents as well as more complex scientific data and an extensive bibliography to allow for further research on a subject of interest. to be an up-to-date information resource for endocrine disruption that is widely trusted, authoritative, and user-friendly to become the preferred source of information and commentary on this issue for members of the public, journalists, public-interest groups, and media commentators to provide a specific focus on the human and animal health studies that seek to define the risks associated with endocrine disrupting substances info@emcom.ca

58. Questions About Endocrine Disruptors Here are some of the most frequently asked questions about the endocrine system and endocrine disruptors What is the endocrine system? http://extoxnet.orst.edu/faqs/pesticide/endocrine.htm

Questions about Endocrine Disruptors Here are some of the most frequently asked questions about the endocrine system and endocrine disruptors: What is the endocrine system? What are hormones? How do hormones work? How do scientists study hormones? ... Links to more information about Endocrine Disruptors What is the endocrine system? The endocrine system is composed of ductless glands that secret hormones into the blood stream to act at distant sites. Together with the nervous system, the endocrine system is responsible for the integration of many different processes which allow complicated organisms to function as a unit (maintain homeostasis). What does the endocrine system look like? What are hormones? Hormones can be proteins, polypeptides, amino acids, or steroids. The most well known hormones are the sex steroids estrogen, produced in the ovaries, and testosterone, produced in the testes. Estrogen and testosterone are also produced in the adrenal glands of both sexes. Other hormones include thyroxin, produced in the thyroid, and insulin, produced in the pancreas. The pituitary and hypothalamus in the brain release a variety of hormones that affect other organs, including the sex glands. How do hormones work?

59. Persistent Organic Pollutants(POPs) These chemical substances persist in the environment, bioaccumulate through the food web, and pose a risk of causing adverse effects to human health and the environment. From the United Nations Environment Programme (UNEP). http://www.chem.unep.ch/pops/

Opportunity for Consultants Persistent Organic Pollutants (POPs) are chemical substances that persist in the environment, bioaccumulate through the food web, and pose a risk of causing adverse effects to human health and the environment. With the evidence of long-range transport of these substances to regions where they have never been used or produced and the consequent threats they pose to the environment of the whole globe, the international community has now, at several occasions called for urgent global actions to reduce and eliminate releases of these chemicals. POPs analysis and monitoring activities Proceedings, Reports and Documents Information on POPs, their Alternatives and Alternative Approaches Global Monitoring of POPs ... CHEMICALS POPs Site Map Search Contact us

60. Endocrine Disruptors, Endocrine Disruption, Endocrine Disrupting Chemicals, Endo Endocrine disruptors; when, where and how they came about http://www.womenlivingnaturally.com/articlepage.php?id=164

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