41. CDC Features - Learn More About Fragile X Syndrome July 22, 2010 is National Fragile X Awareness Day. Fragile X syndrome is the most common known cause of intellectual disability that can be inherited. CDC and its partners have http://www.cdc.gov/Features/FragileX/

42. Fragile X Syndrome / Family Village Fragile X Syndrome Synonyms Martin-Bell Syndrome, Marker X Syndrome, FRAXA, X-Linked Mental Retardation and Macroorchidism. Who to Contact; Where to Go to Chat with Others http://www.familyvillage.wisc.edu/lib_frgx.htm

Fragile X Syndrome Synonyms - Martin-Bell Syndrome, Marker X Syndrome, FRAXA, X-Linked Mental Retardation and Macroorchidism Who to Contact Where to Go to Chat with Others Learn More About It Web Sites ... Waisman Center Fragile X Syndrome Research and Programs Who to Contact FRAXA Research Foundation, Inc. 45 Pleasant St. Newburyport, MA 01950 Fax: (978) 463-9985 E-mail: info@fraxa.org Web: http://www.fraxa.org/ FRAXA was founded in 1994 by three parents of children with Fragile X, Katie Clapp, Michael Tranfaglia MD, and Kathy May, to support scientific research aimed at finding a treatment and a cure for Fragile X. Fragile X research is drastically underfunded, considering its high prevalence, prospects for a cure, and the promise that this research holds for advancing understanding of other disorders like autism, Alzheimer's disease, and X-linked mental retardation. FRAXA funds grants and fellowships at universities all over the world. We have funded more than $7.5 million dollars in top-notch science. FRAXA's overhead expenses have always been just 9% or less of income, as we have just two paid staff and hundreds of volunteer parents. Since FRAXA was founded, the Fragile X field has grown tremendously, due in large part to our grass-roots efforts. You can help us accomplish much more. The National Fragile X Foundation PO Box 37 Walnut Creek, California 94597

43. Fragile X Syndrome - MSN Health & Fitness - Kids' Health Fragile X syndrome is the most common inherited form of mental retardation. It affects about 1 in 4000 males and 1 in 8000 females and occurs in all http://health.msn.com/kids-health/articlepage.aspx?cp-documentid=100169861

44. Fragile X Syndrome: Your Child: University Of Michigan Health System Fragile X syndrome . What is Fragile X syndrome (FXS)? Fragile X syndrome (also called FXS) is the most common cause of inherited mental retardation. http://www.med.umich.edu/yourchild/topics/fragilex.htm

45. Fragile X Syndrome - Definition Of Fragile X Syndrome In The Medical Dictionary Fragile X Syndrome Definition. Fragile X syndrome is the most common form of inherited mental retardation. Individuals with this condition have developmental delay, variable http://medical-dictionary.thefreedictionary.com/fragile X syndrome

46. Fragile X Syndrome fragile syndrome, fragile x syndrome, sex linked disease, sex linked genes, genetic diseases, fragile x, genetical dna errors http://fragilexsyndrome.blogspot.com/

skip to main skip to sidebar Fragile X Syndrome fragile syndrome, fragile x syndrome, sex linked disease, sex linked genes, genetic diseases, fragile x, genetical dna errors Frequently Asked Questions Did I do anything to cause fragile X syndrome? No. There is nothing you did before or during the pregnancy or after your child was born to cause fragile X syndrome. Fragile X syndrome is genetic which means it is caused by a change in a gene, in this case, the FMR1 gene. The change causes the gene not to work the way it should, leading to the problems seen in fragile X syndrome. Because fragile X syndrome is genetic, it can be passed on and you are at risk for having another child with fragile X syndrome. It is important to know that you have no control over whether this change gets passed on to your child or not. In addition, other family members may also be at risk of having children with fragile X syndrome, so it is important to inform them of your child's diagnosis. What does cause fragile X syndrome? Explaining how fragile X happens is not very easy simply because of the way it is inherited. To start, let's talk broadly about genes and chromosomes. Genes are the instructions that tell our bodies how to work and are made up of DNA. We inherit two copies of all of our genes: one copy from our mother and one copy from our father. The DNA is packed into larger structures called chromosomes, and each chromosome contains hundreds to thousands of genes. Most people have 23 pairs of chromosomes, for a total of 46 chromosomes. The first 22 pairs are the same in males and females and are called the autosomes. The 23rd pair, called the sex chromosomes, are different in males and females. Females have two "X" chromosomes, and males have one "X" and one "Y" chromosome.

47. Fragile X Syndrome - Symptoms, Treatment And Prevention of Fragile X Syndrome; Symptoms of Fragile X Syndrome......Symptoms, Treatment and Prevention of Fragile X Syndrome Definition of Fragile X Syndrome; http://www.healthscout.com/ency/68/599/main.html

48. Fragile X Syndrome: Chromosomal And Genetic Abnormalities: Merck Manual Home Edi Fragile X syndrome is a genetic abnormality in the X chromosome that leads to delayed development and other symptoms. The symptoms of fragile X syndrome are caused by abnormalities http://www.merck.com/mmhe/sec23/ch266/ch266c.html

49. Fragile X Syndrome Because Fragile X Syndrome is the leading genetic cause of autism, we've created the Fragile X Awareness bracelet. http://www.lucasworks.org/fragile-x-syndrome.html

LucasWorks TM Products for autism and other special needs. Home About LucasWorks What's New Contact Info ... Cafepress Store Fragile X Syndrome Orders received during that time will be processed and shipped by November 19. Fragile X Syndrome Bracelet Blue, #15FX-B, $22.00 Wrist size: Small-Medium Medium-Large Gift Wrap, $3.00 More about Gift Wrap Our newest addition to the Fragile X Syndrome awareness line, this beautiful bracelet is done in an aqua blue color that reflects the colors used by the FRAXA research foundation. Fragile X Syndrome Bracelet Pink, #15FX-P, $22.00 Wrist size: Small-Medium Medium-Large Gift Wrap, $3.00 More about Gift Wrap The original LucasWorks Fragile X Syndrome bracelet, with a pastel pink base color that goes with everything. Just click on the photos to see a close up of any Fragile X Syndrome jewelry item. Fragile X Syndrome Keychain/Purse Charm Gift Wrap, $3.00 More about Gift Wrap Attach to your keys, your purse, your backpack or computer case! Just like the Fragile X Syndrome Bracelet, this beautiful keychain or purse charm comes complete with a card showing how the beads and charms explain something about Fragile X Syndrome. The Fragile X Syndrome Keychain/Purse charm hangs from a lanyard clip to easily attach to your purse, your keys, or anywhere else, and measures just under six inchs long.

50. Fragile X Syndrome: Chromosomal Anomalies: Merck Manual Professional Fragile X syndrome is a genetic abnormality in an X chromosome that leads to mental retardation and behavioral disorders. Fragile X syndrome is the most common inherited cause http://www.merck.com/mmpe/sec19/ch294/ch294b.html

51. Fragile-X Syndrome What are trinucleotide repeats? DNA, the chemical that makes up our genes, contains a code of three letter words known as codons or trinucleotide repeats. http://www.childrenshospital.org/az/Site1788/mainpageS1788P0.html

advanced search or find by letter: A-F G-L M-R S-Z My Child Has... Home Fragile-X Syndrome Fragile-X Syndrome What are trinucleotide repeats? DNA, the chemical that makes up our genes, contains a "code" of three letter words known as "codons" or "trinucleotide repeats." Many genes normally contain a trinucleotide repeat which is present several times. When the number of trinucleotide repeats increases to a larger than normal number of copies, the DNA is altered, and the gene may not function properly, or may not work at all. It is not well understood what causes a trinucleotide repeat to expand into more than the usual number of copies that should be in a gene. Sometimes, a person may have more than the usual number of copies, but not enough to alter the function of the gene. These individuals are referred to as "permutation carriers." When they pass on these extra copies to a child, however, the extra trinucleotide repeats cause the DNA to become unstable, and the area of DNA expands even more. The result is that the child has a gene that no longer functions, or is not functioning properly and they are said to have the "full mutation." An example of a trinucleotide repeat disease is Fragile-X syndrome. What is Fragile-X syndrome?

52. The National Fragile X Foundation At CNC The National Fragile X Foundation's website contains over 3000 pages of content on the genetic mutation called Fragile X including fragile X syndrome (FXS), fragile http://www.nfxf.org/html/home.shtml

53. Fragile X Syndrome: What Is It? Your Genes, Your Health, DNA Learning Center's multimedia guide to genetic, inherited disorders Fragile X syndrome, sexlinked disorder http://www.ygyh.org/fragx/whatisit.htm

Concept 15 : DNA and proteins are key molecules of the cell nucleus. Learn the basic chemistry of DNA and proteins. Concept 27 : Mutations are changes in genetic information. Find out how mutations affect gene expression. Concept 33 : Genes can be turned on and off. Learn how gene expression is controlled.

54. Genetic Disorders: Fragile X Syndrome What is Fragile X Syndrome? Fragile X Syndrome (FXS) is a hereditary disease and the most common inherited cause of mental impairment. Fragile X Syndrome causes mild to severe http://www.pregnancy-info.net/complications_fragileX.html

getTrigger('5184'); Pregnancy Info HOME Getting Pregnant Pregnancy Pregnancy Health ... Share Fragile X Syndrome netseer_tag_id = "1104"; netseer_ad_width = "480"; netseer_ad_height = "40"; netseer_task = "ad"; What is Fragile X Syndrome? Fragile X Syndrome (FXS) is a hereditary disease and the most common inherited cause of mental impairment. Fragile X Syndrome causes mild to severe mental impairment and includes physical and behavioral characteristics. Related Articles Risk Factors Pregnancy Complications Complications with Baby Chromosomal Abnormalities ... Pregnancy Pain netseer_tag_id = "1105"; netseer_ad_width = "480"; netseer_ad_height = "90"; netseer_task = "ad"; Causes of Fragile X Syndrome Fragile X Syndrome occurs when a certain gene (FMR-1) mutates or changes. The FMR-1 gene mutates by expanding or repeating certain chemical components of DNA (CGG). Everyone has the FMR-1 gene, but whereas the general population has between 5 and 40 repeats, carriers of FXS have between 55 and 200 repeats. This is called the premutation stage. Individuals with the full mutation have over 200 repeats. The full mutation causes the FMR-1 gene to turn off. That means the FMR-1 gene is not working properly and not producing the protein it is supposed to. This protein is crucial to intellectual development and functioning. Characteristics of Fragile X Syndrome Characteristics of Fragile X Syndrome fall into three categories: physical, behavioral and cognitive. Males are usually more affected by these characteristics than females.

55. Abington Pediatric Associates-Medical Conditions: Fragile X Syndrome by Randi Hagerman, M.D. Professor of Pediatrics, University of Colorado Health Sciences Center and The Children's Hospital Denver, Colorado. What is fragile X syndrome? http://www.abingtonpeds.com/resources/fragilexsyndrome.asp

@import "/meta/template168.css"; @import "/meta/printtemplate168.css"; Fragile X Syndrome What is fragile X syndrome? What causes fragile X syndrome? Who gets fragile X syndrome? How does a FMR1 mutation cause disease? ... Reading for children by Randi Hagerman, M.D. Professor of Pediatrics, University of Colorado Health Sciences Center and The Children's Hospital Denver, Colorado What is fragile X syndrome? Fragile X syndrome, also known as FXS, is a genetic disorder, which causes a wide range of problems, from learning disabilities or attention deficits to more significant developmental delays or mental retardation. Fragile X syndrome also can cause significant emotional or behavioral problems, including anxiety, panic attacks, and hyperactivity or Attention Deficit Hyperactivity Disorder (ADHD). Fragile X syndrome is the most common cause of inherited mental retardation. top What causes fragile X syndrome? Fragile X syndrome is caused by a mutation in the Fragile X Mental Retardation 1 gene (FMR1), which is located on the bottom end of the X chromosome. The FMR1 gene produces a protein that is important for normal brain development. In studies, where the X chromosome is viewed under the microscope, it narrows at the site of the mutation. This narrowing makes the X chromosome look fragile, as if it would break, hence the name, fragile X syndrome. The mutation is made up of a repeat of the DNA nucleotide code, CGG. If you think of DNA as a twisted ladder, the nucleotides represent the rungs on the ladder, and, at the FMR1 gene, one side of the ladder has the repetitive CGG sequence. In normal individuals, there are approximately 5 to 50 CGG repeats. In individuals who are carriers of fragile X syndrome, but, usually, are not intellectually affected, the CGG repeat is expanded from approximately 50 to 200 repeats. In individuals who are significantly affected by fragile X syndrome, the CGG repetitions expand to greater than 200, and, sometimes, up to 2,000. This is called the full mutation.

56. Mountain States Genetics Foundation Fragile X Syndrome. Introduction. Fragile X syndrome is the most common cause of inherited mental retardation with an incidence of approximately 1 in 2000 male, and 1 in 2500 http://www.mostgene.org/gd/gdvol16d.htm

Home About Us Board of Directors 2010 Annual Education Conference ... Next Section Vol. 16: Summer, 1998 Management of Common Genetic Disorders Fragile X Syndrome Introduction Fragile X syndrome is the most common cause of inherited mental retardation with an incidence of approximately 1 in 2000 male, and 1 in 2500 female, live births. The carrier frequency in females is 1/259 and in males is 1/755. Fragile X syndrome is an X-linked disorder and occurs with equal frequency in all ethnic groups. Fragile X syndrome is responsible for approximately 10% of all cases of inherited mental retardation and 30% of cases of X-linked mental retardation. The gene responsible for fragile X syndrome is located on the X chromosome and is known as the Fragile X Mental Retardation 1 (FMR1) gene. Within the FMR1 gene is a specific region of CGG repeats. Individual with fewer than 40 repeats are not at risk to pass on fragile X syndrome to their offspring. Individuals with 55 to 200 repeats are said to carry the FMR1 premutation. Male individuals with more than 200 repeats have fragile X syndrome. Females with more than 200 repeats have a 50-70% risk to have a low or borderline IQ and a 30-50% chance to have a normal IQ. Approximately 60% of females with more than 200 repeats and a normal IQ have learning problems and emotional or behavioral difficulties. There are a few reports in the literature documenting fragile X syndrome due to deletions of the FMR1 gene, but the vast majority of cases are the result of expansion of the CGG triplet repeat within the FMR1 gene. Expansion occurs when the gene mutation is passed from the mother to the child.

A  B  C  D  E  F  G  H  I  J  K  L  M  N  O  P  Q  R  S  T  U  V  W  X  Y  Z

Page 3     41-56 of 56    Back | 1  | 2  | 3