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         Gene Therapy:     more books (100)
  1. The Ethics of Human Gene Therapy by LeRoy Walters, Julie Gage Palmer, 1996-11-14
  2. A Guide to Human Gene Therapy by Roland W. Herzog, 2010-06-18
  3. Molecular Genetics & Gene Therapy of Cardiovascular Diseases (Fundamental and Clinical Cardiology) by S. C. Mockrin, 1996-01-02
  4. Gene Therapy Protocols (Methods in Molecular Medicine)
  5. Gene Therapy: Treating Disease by Repairing Genes (New Biology) by Joseph, Ph.D. Panno, 2004-10
  6. A Guide to Complementary Treatments for Diabetes: Using Natural Supplements, Nutrition, and Alternative Therapies to Better Manage Your Diabetes by Gene Bruno, 2009-11
  7. Stem Cell and Gene-Based Therapy: Frontiers in Regenerative Medicine
  8. Immunology of Gene Therapy by Roland W. Herzog, 2008-12-03
  9. Gene Therapy and Gene Delivery Systems (Advances in Biochemical Engineering Biotechnology)
  10. Cell, Gene and Molecular Therapy: New Concepts (Nova Biomedical) by Viroj Wiwanitkit, 2009-01
  11. Gene and Cell Therapy: Therapeutic Mechanisms and Strategies, Third Edition
  12. Gene Therapy for Cancer (Cancer Drug Discovery and Development)
  13. Viral Vectors: Gene Therapy and Neuroscience Applications
  14. Human Gene Therapy by Eve Nichols, 1988-03-22

1. Gene Therapy - Wikipedia, The Free Encyclopedia
Gene therapy is the insertion of genes into an individual's cell and biological tissues to treat disease, such as cancer where deleterious mutant alleles are replaced with
http://en.wikipedia.org/wiki/Gene_therapy
Gene therapy
From Wikipedia, the free encyclopedia Jump to: navigation search Gene therapy Gene therapy is the insertion of genes into an individual's cell and biological tissues to treat disease , such as cancer where deleterious mutant alleles are replaced with functional ones. Although the technology is still in its infancy, it has been used with some success. Scientific breakthroughs continue to move gene therapy toward mainstream medicine.
Contents

2. Gene Therapy: News & Videos About Gene Therapy - CNN.com
Researchers at the University of Pennsylvania announced in April 2008 the use of an innovative gene therapy treatment to safely restore vision in three adults with a rare form of
http://topics.cnn.com/topics/gene_therapy

3. Gene Therapy And Children
Development information for the clinical use of gene therapy for children with severe illnesses.
http://kidshealth.org/parent/system/medical/gene_therapy.html

4. Gene Therapy - An Overview
Gene Therapy An Overview BIO. Biotechnology in Perspective. Washington, D.C. Biotechnology Industry Organization, 1990.
http://www.accessexcellence.org/RC/AB/BA/Gene_Therapy_Overview.html

5. Gene Therapy - Encyclopedia Article - Citizendium
This is a draft article, under development and not meant to be cited; you can help to improve it. These unapproved articles are subject to a disclaimer.
http://locke.citizendium.org:8080/wiki/Gene_therapy
Gene therapy
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This is a draft article , under development and not meant to be cited; you can help to improve it. These unapproved articles are subject to edit intro According to hematologist Arthur Nienhuis, former president of the American Society of Gene Therapy, gene therapy ....is the addition of new genes to a patient’s cells to replace missing or malfunctioning genes. Researchers typically use a virus to carry the genetic cargo into cells, because that is what viruses evolved to do with their own genetic material. In 2008, Arthur Nienhuis reported that gene therapy cured 90% of the 30 treated patients with a genetic disorder called severe combined immunodeficiency disease (SCID), children who cannot ward off routine infections and die in childhood (bubble-boys). The gene therapists inserted the therapeutic gene in the SCID patients using a category of virus known as retroviruses, which have an easy time inserting their genes among the DNA of the patient. The method has the possibility the retrovirus will insert its genes where it can adversely affect other genes and cause leukemia. Fortunately the risk seems small, and the leukemia mostly curable. With larger numbers of patients treated and followed throughout their life, gene therapist can assess the full potential for cure and for adverse effects in SCID.

6. Online NewsHour: Gene Therapy -- December 8, 1999
December 8, 1999 . The National Institutes of Health and the Food and Drug Administration opened hearings to explore the safety of gene therapy treatment after
http://www.pbs.org/newshour/bb/health/july-dec99/gene_therapy.htm
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GENE THERAPY
December 8, 1999
The National Institutes of Health and the Food and Drug Administration opened hearings to explore the safety of gene therapy treatment after a teen died while receiving the experimental care. Susan Dentzer reports on the procedure and its controversy. The Health Unit is a partnership with the Henry J. Kaiser Family Foundation.
Health Spotlight on

Gene Therapy
Dec. 2, 1999:

Breaking the Code
Nov. 30, 1999:
Medical Errors
Focus: Internet Rx Nov. 11, 1999:
Hope for the Heart
Nov. 9, 1999:
What the Doctor Ordered
Nov. 1, 1999:
Patient Privacy
Browse the NewsHour's coverage of health. American Society of Gene Therapy Dr. W. French Anderson Human Gene Therapy RAY SUAREZ: Now, an inquiry into the developing science of gene therapy, reported by Susan Dentzer of our health unit, a partnership with the Henry J. Kaiser Family Foundation.

7. Online NewsHour: Gene Therapy -- February 2, 2000
February 2, 2000 . As gene therapy trials come under fire for underreporting harmful side effects, Congress begins investigating the proper balance between regulation
http://www.pbs.org/newshour/bb/health/jan-june00/gene_therapy_2-2.html
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GENE THERAPY
February 2, 2000
As gene therapy trials come under fire for underreporting harmful side effects, Congress begins investigating the proper balance between regulation and research. Susan Dentzer reports on developments in controversial gene therapy treatments. The Health Unit is a partnership with the Henry J. Kaiser Family Foundation.
Health Spotlight on Gene Therapy
Dec. 8, 1999:

Controversial Therapy
Dec. 2, 1999:
Breaking the Code
Nov. 30, 1999:
Medical Errors
Focus: Internet Rx Browse the NewsHour's coverage of health. American Society of Gene Therapy Dr. W. French Anderson SUSAN DENTZER: The promise of gene therapy has long seemed spectacular: Prevent or cure illness by injecting healthy copies of defective or missing genes into the body. But the death of a teenager last fall in a controversial gene therapy clinical trial focused a harsh spotlight on the ways these experiments are being carried out and monitored. That was the subject of a senate subcommittee hearing today chaired by Republican Senator William Frist of Tennessee. SEN. WILLIAM FRIST: If we ask patients to participate in moving science forward, then we must be assured that gene therapy clinical trails are safe. I hope that today's hearing will be a thoughtful discussion and provide a thorough review of the oversight mechanisms that are in place. There is absolutely no room, no place for mistakes that compromise patient safety.

8. American Hair Loss Association - Hair Loss Research / Gene Therapy
Consumer hair loss information. Devoted to finding a cure for hair loss and increasing worldwide awareness and understanding of this disease.
http://americanhairloss.org/hair_loss_research/gene_therapy.asp
Home Community Donate About Us ... Site Index Site Search
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Gene Therapy
Gene Therapy
An even more advanced technique for solving inherited hair loss in the future is gene therapy. Gene therapy is the process of changing genes of existing cells in the body, and thereby altering cell function. It is a medical treatment still in its infancy, and there have only been a few recent examples of gene therapy working. But it is a potential future baldness treatment method worth exploring. Gene therapy requires learning how an inherited medical condition occurs at the DNA molecule level, and then going in and fixing it. With gene therapy, the hair follicles with DHT-sensitive cells could be changed into follicles with DHT-resistant cells, and the hair follicles would continue to grow new hairs for a lifetime. But gene therapy involves several very difficult to achieve steps. The first step is figuring out which of the tens of thousands of genes on strands of DNA are involved in the characteristic to be altered, and the second step is figuring out how exactly the target genes are to be changed, so that they give instructions for making the slightly different proteins that will achieve the desired effect. The third step is getting the target cells in the living organism to incorporate the new and improved genes as replacements for the old undesirable genes. Gene Identification:
Figuring out which genes are involved in the genetic condition to be changed is not an easy task. Despite all the advances in mapping genes in recent years, we are still very far away from knowing what most of these genes do. We certainly do not have a good understanding of all of the genes that affect the cycle of hair growth, and especially which genes are responsible for inherited hair loss. It is most likely that several genes are responsible for making proteins that cause certain hair follicles to be DHT-sensitive.

9. Gene Therapy
Gene Therapy . One of the most amazing genetic applications in medicine is gene therapy.
http://library.thinkquest.org/28599/gene_therapy.htm
Gene Therapy One of the most amazing genetic applications in medicine is gene therapy. Also known as somatic gene therapy and therapeutic gene therapy, this procedure involves inserting (or sometimes deleting) portions of the genes in diseased patients so that they can be cured and live healthier lives. Bone marrow
By permission Nanoworld Image Gallery

Posted by permission Mark Parisi

Liver cell nucleus
There are other gene therapy techniques, although they aren’t as frequently used. One method involves inserting therapeutic DNA into cultured endothelium tissue (endothelium is the membrane that lines all of the blood vessels) and then grafting it into the patient. Another technique requires the patient to receive an electric shock while submerged in a bath of a therapeutic DNA solution. The shock opens the skin pores, allowing the DNA to enter. Still other options include skin grafts, connective tissue grafts, and injecting the liver with the therapeutic DNA.

10. Gene Therapy Summary And Analysis Summary | BookRags.com
Gene therapy summary with 240 pages of lesson plans, quotes, chapter summaries, analysis, encyclopedia entries, essays, research information, and more.
http://www.bookrags.com/Gene_therapy

11. Gene Therapy
Gene therapy is the insertion of genes into an individual's cells and tissues to treat a disease, and hereditary diseases in which a defective mutant allele is replaced with a
http://www.sciencedaily.com/articles/g/gene_therapy.htm
Science Reference
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Gene therapy
Gene therapy is the insertion of genes into an individual's cells and tissues to treat a disease, and hereditary diseases in which a defective mutant allele is replaced with a functional one. See also: Although the technology is still in its infancy, it has been used with some success. Antisense therapy is not strictly a form of gene therapy, but is a genetically-mediated therapy and is often considered together with other methods. In most gene therapy studies, a "normal" gene is inserted into the genome to replace an "abnormal," disease-causing gene. A carrier called a vector must be used to deliver the therapeutic gene to the patient's target cells. Currently, the most common type of vectors are viruses that have been genetically altered to carry normal human DNA. Viruses have evolved a way of encapsulating and delivering their genes to human cells in a pathogenic manner. Scientists have tried to harness this ability by manipulating the viral genome to remove disease-causing genes and insert therapeutic ones. Target cells such as the patient's liver or lung cells are infected with the vector.

12. ScienceDaily: Gene Therapy News
Read all about gene therapy including current medical research on switching therapeutic genes on and off, lightactivated gene therapy and gene silencing.
http://www.sciencedaily.com/news/health_medicine/gene_therapy/
Gene Therapy News
Monday, November 1, 2010 Print Email Bookmark
Latest News
Medical Topics Your Health
Breakthrough Gene Therapy Prevents Retinal Degeneration
full story
Gene Therapy Reverses Type 1 Diabetes in Mice, Experimental Technique Shows
full story ... Toward Making the Blind See: Gene Therapy Restores Vision in Mice
Browse News Stories
1 to 10 of 310 stories (42 over past year) view headlines only

13. Gene Therapy
Definition, hurdles, ethical issues, and links to more resources on gene therapy provided by the Oak Ridge National Laboratory.
http://www.ornl.gov/sci/techresources/Human_Genome/medicine/genetherapy.shtml
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What is gene therapy?
Gene therapy is a technique for correcting defective genes responsible for disease development. Researchers may use one of several approaches for correcting faulty genes:

14. Gene Therapy Net - News, Clinical Trials, Viral Vectors And Patient Information
Information resource for gene therapy news, clinical trials, guidelines, regulation, literature, databases and educational information, scientific research articles and more gene therapy information
http://www.genetherapynet.com

15. Gene Therapy
Gene therapy is an experimental technique that uses genes to treat or prevent disease. In the future, this technique may allow doctors to treat a disorder by inserting a gene
http://www.nature.com/gt/index.html
Login Search This journal All of nature.com Advanced search
Welcome to Gene Therapy
At the forefront of medicine, Gene Therapy Free online issue Volume 17, No 10
October 2010
ISSN: 0969-7128
EISSN: 1476-5462 2009 impact factor
Editors:
J Glorioso, USA
N Lemoine, UK 2009 Journal Citation Reports (Thomson Reuters, 2010)
FEATURED ARTICLES
SHORT COMMUNICATION
Long-term transgene expression in immunocompetent mice using an EBV episome delivered with a self-circularising, helper-dependent adenovirus
ORIGINAL ARTICLE
Mifepristone increases gamma-retroviral infection efficiency by enhancing the integration of virus into the genome
ORIGINAL ARTICLE
Preclinical correction of human Fanconi anemia complementation group A bone marrow cells using a safety-modified lentiviral vector Current issue table of contents Advance online publication in full
News
'Open' option for authors now available
Open Gene Therapy now offers authors the option to publish their articles with immediate open access upon publication. Open access articles will also be deposited on PubMed Central at the time of publication and will be freely available immediately. Find out more from our FAQs page
Addgene: Recombinant DNA Technology Award
Has your lab been working on designing a unique plasmid or cDNA element that will help solve current challenges in your field? The "Recombinant DNA Technology Award" from Addgene was created to recognize laboratories that are using innovative strategies to build novel DNA tools. Visit the

16. Genetherapy
Aggregate news portal for research and news.
http://www.GeneTherapy.me
Genetherapy
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Macula Risk detects variations in genetic markers known to predict the progression of early asymptomatic AMD to blindness using a cheek swab sample.

17. University Of North Carolina At Chapel Hill's Gene Therapy Department
Dr. Samulski and members of the Gene Therapy Center have recently developed novel viral vectors with targeting capability.
http://genetherapy.unc.edu/samulski.htm
Research Samulski Lab
Kafri Lab

Monahan Lab
... Gene Therapy Links Samulski Lab Director: R. Jude Samulski, PhD Laboratory phone: 919.966.0905 Dr. Samulski and members of the Gene Therapy Center have recently developed novel viral vectors with targeting capability. These reagents will be of significant value when transducing specific cell types such as hepatocytes. One of the great aspirations of gene therapy is to eventually develop technology which will provide a feasible approach to correcting genetic defects and combating infectious diseases. The laboratory is engaged in studying the molecular biology of the defective human parvovirus adeno-associated virus (AAV) in hopes of developing a safe, efficient viral vector for human gene therapy. Ongoing research is revealing that this nonpathogenic human virus is now accessible for utilization as a vector. We have developed a packaging system which allows for efficient encapsidation of foreign genes into AAV virions. We have also indentified the essential cis -acting sequencing required for efficient integration into host cell DNA. Finally, we have characterized this integration step and uncovered the exciting result of site-specific integration. this last observation clearly sets AAV apart as a eucaryotic viral vector and its potential for gene therapy in humans. Our continued efforts to understand and manipulate this virus as a vector has required a multi-faceted approach from basic virology

18. Department Of Health: Gene Therapy Advisory Committee
Advises on the ethical acceptability of proposals for gene therapy research on humans taking account of the scientific merits and the potential benefits and risks, and provides advice to UK Health Ministers on developments in gene therapy research.
http://www.advisorybodies.doh.gov.uk/genetics/gtac/

DH Home
You are here: Advisory bodies GTAC About GTAC Gene therapy Stem cell therapy Application procedures ... Contact GTAC Gene Therapy Advisory Committee (GTAC) You are being redirected to the new site for Department of Health advisory bodies: http://www.dh.gov.uk/ab/GTAC/index.htm Please adjust your bookmarks Top Search Entire site Public Health and Clinical Quality Genetics Human Genetics Commission ... Download Adobe Acrobat reader for PDF files Help with Portable Document Format (PDF)

19. Gene Therapy: Definition From Answers.com
n. The treatment of certain disorders, especially those caused by genetic anomalies or deficiencies, by introducing specific engineered genes into a patient's cells.
http://www.answers.com/topic/gene-therapy

20. GENE THERAPY
Contents. Introduction; Potential Ethical Issues; Is it acceptable for human beings to manipulate human genes? Risk and the need for humility and prudence in genetic developments
http://www.srtp.org.uk/genthpy1.htm

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Perhaps the most basic underlying questions centre on a Christian understanding of the human being.
  • What does this tell us vis a vis our genetic and physical makeup?
  • What are therefore proper interventions into that genetic makeup?
  • What would be improper in terms of our human dignity?

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