41. Mitochondrial Genetics: A Paradigm For Aging And Degenerative Diseases? -- Walla Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions or possibly that you are using a browser http://www.sciencemag.org/cgi/content/abstract/256/5057/628

42. Gene Expression: Mitochondrial Genetics Most studies of the genetics of human traits focus on a specific disease phenotype, or some extreme of phenotypic variation that a clinician can call pathological . http://www.gnxp.com/blog/2007/06/mitochondrial-genetics.php

43. Centre For Reproduction & Development Areas of research Mitochondrial Genetics; Endocrinology immunophysiology; Amnion stem cells; Reprogramming of somatic cells http://www.monashinstitute.org/centres/crd/mitochondrial-reproductive-genes.html

Home About Us Research Centres Info at a glance ... The Ritchie Centre Mitochondrial Genetics Lab head: Professor Justin St. John The overall aim of our research is to understand how mitochondrial DNA (mtDNA) is replicated, transmitted and segregated so that cellular and reproductive strategies can be developed for current patients and to prevent the transmission of mutant mtDNA to subsequent generations. Mapping mtDNA We have mapped the patterns of replication and transmission as mtDNA passes from the fertilised oocyte into preimplantation embryos, fetuses and live offspring. Furthermore, we have studied these events following nuclear transfer and shown that donor cell mtDNA is also transmitted at highly variable levels due to the premature expression of the mtDNA specific replication factors resulting in heteroplasmy. To provide a more focussed molecular analysis during lineage specific differentiation, we have mapped mtDNA replication events in pluripotent and differentiating embryonic stem cells, which appear to coincide with the types of ATP-generating pathway used at various stages of development. Strategies in depleting mtDNA from donor cells By depleting donor cell mtDNA prior to NT, we have generated live offspring that inherit their mtDNA from the oocyte only. We will apply this knowledge to karyoplast transfer to develop strategies to prevent the transmission of mutant mtDNA to subsequent generations. These strategies will also be transferable to assisted reproduction and stem cell derivation approaches.

44. Mitochondrial Genetics Of Recovery After Brain Injury University of Pittsburgh study. Funding Agency National Institutes of Health, National Institute of Nursing Research (Grant No. R01 NR008424) http://www.neurosurgery.pitt.edu/research/projects/clinical_trials/tbi_genetics.

University Home Medical Center Home Home Overview ... Safar Center Labs: Walter L. Copeland Lab Neuroapoptosis Lab Surgical Neuroanatomy Lab Spine Biomechanics Lab Clinical Trials Mitochondrial Genetics of Recovery after Brain Injury Funding Agency: National Institutes of Health, National Institute of Nursing Research (Grant No. R01 NR008424) Total Project Period: Total Project Award: Principal Investigators: Yvette P. Conley, PhD (School of Nursing) Co-Investigators: David O. Okonkwo, MD, PhD ; Yookung Kim, PhD (School of Nursing) Project Summary: The magnitude of traumatic brain injury (TBI) related death and disability in the country supports investigating factors related to functional outcome attained after a TBI. The level of functional outcome that is attained by a TBI victim is highly variable, even when age, injury and care are similar, however the basis for this variability has never been adequately explained, and may hold the key to improving patient outcomes after a TBI. This study will take the approach that individual genetic variation may play a role in level of functional outcome attained after TBI and will specifically focus on individual mitochondrial genetics and mitochondrial energy production. A well-characterized cohort of TBI patients who have agreed to participate in a study on the genetics of recovery after TBI is available through the Brain Trauma Research Center (BTRC) at the University of Pittsburgh.

45. Mitochondrial Genetics* 1. Introduction The mitochondrial genome is indispensable to the cellular and organismal biology of Caenorhabditiselegans . An elaborate cellular machinery is employed to maintain http://www.wormbook.org/chapters/www_mitogenetics/mitogenetics.pdf

46. Mitochondrial Genetics Of Aging: Intergenomic Conflict Resolution -- Rand 2005 ( Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions or possibly that you are using a browser http://sageke.sciencemag.org/cgi/content/abstract/2005/45/re5

47. Postdoc: Mitochondrial Genetics Of Aging At Brown University - Molecular Biology Postdoc at Brown University Mitochondrial genetics of aging in Drosophila A postdoc position is available in the laboratory of David Rand and Brown University to work on http://www.molecularstation.com/forum/drosophila-forum/71679-postdoc-mitochondri

/** * vBulletin 3.8.4 CSS * Style: 'Default Style'; Style ID: 15 */ @import url("clientscript/vbulletin_css/style-8dbca84f-00015.css"); window.templatePath = 'templates/rt_hyperion'; Member Login Remember me Lost Password? Member Login Science Home Contact Us Link To Us Science Home ... Drosophila Forum Postdoc: Mitochondrial genetics of aging at Brown University User Name Remember Me? Password Register Blogs vbmenu_register("vbbloglinks"); Blogs Recent Entries Best Entries Best Blogs ... Science Groups New! Arcade Search Today's Posts Mark Forums Read Drosophila Forum Drosophila melanogaster Forum. Discuss and post questions about FlyBase, Drosophila cloning, fruit fly gene crosses expression and analysis. Postdoc: Mitochondrial genetics of aging at Brown University Postdoc: Mitochondrial genetics of aging at Brown University - Drosophila Forum Postdoc: Mitochondrial genetics of aging at Brown University - Drosophila melanogaster Forum. Discuss and post questions about FlyBase, Drosophila cloning, fruit fly gene crosses expression and analysis. LinkBack Thread Tools Display Modes permalink 10-07-2009, 06:03 PM

48. Welcome To Mitochondria Research Society THE MITOCHONDRIAL GENETICS MAZE . The inheritance patterns of the mitochondrial encephalomyopathies can be quite complicated. http://www.mitoresearch.org/mitodiseases2.html

MITOCHONDRIAL MYOPATHY: AN ENERGY CRISIS IN THE CELLS by Sharon Hesterlee :: Story Continue from Previous Screen :: THE MITOCHONDRIAL GENETICS MAZE . The inheritance patterns of the mitochondrial encephalomyopathies can be quite complicated. The mutations that cause these diseases can be in the chromosomes; this is what's usually meant when people talk about a genetic or inherited disease. But mitochondrial encephalomyopathies have a unique situation. People can also inherit one of these diseases through mutations in the mitochondrial DNA (mtDNA), which comes from the mother only. Mitochondria are the only parts of the cells that have their own DNA, separate from that of the chromosomes in the cell's nucleus, called nuclear DNA. This situation occurs because the mitochondrial respiratory chain, which is the final step in the energy-making process, is made up of proteins that come from both nuclear and mtDNA (see illustration). Although only 13 of roughly 100 respiratory chain proteins come from the mtDNA, these 13 proteins contribute to every part of the respiratory chain except complex II, and 24 other mitochondrial genes are required just to manufacture those 13 proteins. Thus, a defect in either a nuclear gene or one of the 37 mitochondrial genes can cause the respiratory chain to break down. (This respiratory chain has nothing to do with breathing.)

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