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Goldstein Joseph L:     more detail

Great Issues for Medicine in the Twenty-First Century: Ethical and Social Issues Arising Out of Advances in the Biomedical Sciences (Annals of the New York Academy of Sciences) Values and Visions. a Merck Century. by Louis, Michael S. Brown, Joseph L. Goldstein And P. Roy Vagelos. Galambos, 1991 Snoring Can Kill!!: Discover How Sleep Apnea Can Be Ruining Your Life by Joseph L. Goldstein, 1999-10-01 Roundtable: the human genome project. (forum at University of Texas Southwestern Medical Center on May 6, 1993) (Transcript): An article from: Issues in Science and Technology by Michael S. Brown, Francis Collins, et all 1993-09-22 Washington and Lee University Alumni: Pat Robertson, John J. Crittenden, Joe Wilson, John Warner, Tom Wolfe, Joseph L. Goldstein, John W. Davis Bottom Line's Brain Boosting Library: The Natural Insomnia Cure, Secrets of Super Memory, Amazing Breakthroughs for Undoing Depression, the Greatest Sex of Your Life, No More Alzheimer's (Paperback 2008 Printing, First Edition) by Paul J. Sorgi, Edward L. Schneider, et all 2008 American Geneticists: Thomas Hunt Morgan, Barbara Mcclintock, Theodosius Dobzhansky, Craig Venter, Susan Lindquist, Joseph L. Goldstein Familial hypercholesterolemia and other disorders of lipoprotein metabolism (Medical Grand Rounds) by Joseph L Goldstein, 1979 a1-Antitrypsin deficiency: From the bench to the bedside (Medical Grand Rounds) by Joseph L Goldstein, 1981 L'Expérience de la clarté intérieure by Joseph Goldstein, 1997-12-01 Everton's Genealogical Helper September/october 1991 by David L. Mishkin, Stephen H. Goldstein, et all 1991 One Dharma: The Emerging Western Buddhism by Joseph Goldstein, 2003-07 Joseph Leonard Goldstein: An entry from Gale's <i>Science and Its Times</i> by Evelyn B. Kelly, 2001 Michael S. Brown: An entry from Gale's <i>Science and Its Times</i> by Judson Knight, 2001

lists with details

21. Articles By Author: Brown, Michael S.; Collins, Francis; Goldstein, Joseph L.; W
    Free Online Library Articles by Brown, Michael S.; Collins, Francis; Goldstein, Joseph L.; Watson, James D.; Wexler, Nancy Sabin  
    http://www.thefreelibrary.com/Brown, Michael S.; Collins, Francis; Goldstein, Jo
    
    Extractions: 18,321,027 articles and books Periodicals Literature Keyword Title Author Topic Member login User name Password Remember me Join us Forgot password? Submit articles free The Free Library out of article(s) Title Type Date Words Roundtable: the human genome project. Transcript Sep 22, 1993 Publications by Name Publications by Date Authors Literature A-D E-O P-T U-Z ... Submit articles

22. Michael Stuart Brown: Facts, Discussion Forum, And Encyclopedia Article
    A geneticist is a scientist who studies genetics, the science of heredity and variation of organisms. A geneticist can be employed as a researcher or lecturer.  
    http://www.absoluteastronomy.com/topics/Michael_Stuart_Brown
    
    Extractions: Home Discussion Topics Dictionary ... Login Michael Stuart Brown Discussion Ask a question about ' Michael Stuart Brown Start a new discussion about ' Michael Stuart Brown Answer questions from other users Full Discussion Forum Encyclopedia Michael Stuart Brown (born April 13, 1941 in Brooklyn, New York) is an American geneticist Geneticist A geneticist is a scientist who studies genetics, the science of heredity and variation of organisms. A geneticist can be employed as a researcher or lecturer. Some geneticists perform experiments and analyze data to interpret the inheritance of traits.... and Nobel Laureate. He was awarded the Nobel Prize in Physiology or Medicine Nobel Prize in Physiology or Medicine The Nobel Prize in Physiology or Medicine administered by the Nobel Foundation, is awarded once a year for outstanding contributions in the medical field. It is one of five Nobel Prizes established in 1895 by Swedish chemist Alfred Nobel, the inventor of dynamite, in his will, the others being...

23. Regeneron Pharmaceuticals, Inc. (REGN.O) Insider Trading | Reuters.com
    GOLDSTEIN JOSEPH L Name Age Since Current Position; Vagelos, P. Roy 80 1995 Chairman of the Board Schleifer  
    http://www.reuters.com/finance/stocks/insiderTrading?symbol=REGN.O&name=GOLD

24. Scientific Commons Homocystinuria Heterozygote Detection Using
    Goldstein, Joseph L., Campbell, Barbara K., Gartler, Stanley M. Abstract Deficiency of cystathionine synthase activity results in the clinical syndrome of homocystinuria.  
    http://en.scientificcommons.org/19150161

25. Michael S. Brown News - The New York Times
    more on michael s. brown and quotation of the day, blood, medicine and health, cholesterol, goldstein, joseph l  
    http://topics.nytimes.com/topics/reference/timestopics/people/b/michael_s_brown/
    
    Extractions: @import url(http://graphics8.nytimes.com/css/topic/screen/200704/topic.css); Search All NYTimes.com Monday, November 1, 2010 World U.S. N.Y. / Region ... B > Brown, Michael S. E-MAIL News about Michael S. Brown, including commentary and archival articles published in The New York Times. Newest First Oldest First Page: Nation's Largest Medical Prize Goes to 2 for Cholesterol Work By RICHARD PÉREZ-PEÑA Albany Medical Center Prize, nation's largest prize in medicine, is awarded to Dr Joseph L Goldstein and Dr Michael S Brown for their pioneering work on function and control of cholesterol May 1, 2003 MORE ON MICHAEL S. BROWN AND: HEART RESEARCH ALBANY MEDICAL CENTER PRIZE IN MEDICINE AND BIOMEDICAL RESEARCH CHOLESTEROL ... 5 GET LASKER AWARDS FOR ADVANCING PUBLIC HEALTH By WALTER SULLIVAN Five individuals who in diverse ways have made significant contributions to the public health of the nation have been named this year's winners of the Albert Lasker Medical Research and Public Service Awards, each of which includes a $15,000 prize. The Basic Medical Research Award will go to Dr. Michael S. Brown and Dr. Joseph L. Goldstein, of the University of Texas Health Science Center. The two men were recently chosen for the Nobel Prize in Medicine and Physiology for their research on chol... November 21, 1985

26. Retinal Degeneration In Choroideremia: Deficiency Of Rab Geranylgeranyl Transfer
    Title Retinal Degeneration in Choroideremia Deficiency of Rab Geranylgeranyl Transferase Authors Seabra, Miguel C.; Brown, Michael S.; Goldstein, Joseph L.  
    http://adsabs.harvard.edu/abs/1993Sci...259..377S
    
    Extractions: 10.1126/science.8380507 Bibliographic Code: Abstract Rab geranylgeranyl transferase (GG transferase) is a two-component enzyme that attaches 20-carbon isoprenoid groups to cysteine residues in Rab proteins, a family of guanosine triphosphate-binding proteins that regulate vesicular traffic. The mutant gene in human choroideremia, an X-linked form of retinal degeneration, encodes a protein that resembles component A of rat Rab GG transferase. Lymphoblasts from choroideremia subjects showed a marked deficiency in the activity of component A, but not component B, of Rab GG transferase. The deficiency was more pronounced when the substrate was Rab3A, a synaptic vesicle protein, than it was when the substrate was Rab1A, a protein of the endoplasmic reticulum. The data imply the existence of multiple component A proteins, one of which is missing in choroideremia. Bibtex entry for this abstract Preferred format for this abstract (see Preferences Use: Authors Title Abstract Text Return: Query Results Return items starting with number

27. A Receptor-Mediated Pathway For Cholesterol Homeostasis
    Title A ReceptorMediated Pathway for Cholesterol Homeostasis Authors Brown, Michael S.; Goldstein, Joseph L. Publication Science, Volume 232, Issue 4746, pp. 34-47  
    http://adsabs.harvard.edu/abs/1986Sci...232...34B

28. Scientific Commons Cystathionine Synthase Activity In Human
    Goldstein, Joseph L., Campbell, Barbara K., Gartler, Stanley M. Abstract Uncultured human leukocytes contain no detectable cystathionine synthase activity.  
    http://en.scientificcommons.org/11759605

29. Regeneron - Statement Of Changes Of Beneficial Ownership
    GOLDSTEIN JOSEPH L 2. Issuer Name and Ticker or Trading Symbol REGENERON PHARMACEUTICALS INC REGN 5. Relationship of Reporting Person(s) to Issuer (Check all  
    http://investor.regeneron.com/secfiling.cfm?filingID=1237899-10-23

30. Abstracts: SREBP Cleavage-activating Protein (SCAP) Is Required For Increased Li
    author Brown, Michael S., Goldstein, Joseph L., Shimomura, Iichiro, Matsuda, Morihiro, Korn, Bobby S., Hammer, Robert E., Moon, YoungAh, Komuro, Ryutaro, Horton, Jay D.  
    http://www.faqs.org/abstracts/Biological-sciences/SREBP-cleavage-activating-prot
    
    Extractions: Faqs.org homepage Abstracts index Biological sciences Article Abstract: Results demonstrate that in sterol-treated mammalian cells, the polytopic membrane SREBP Cleaving-Activating-Protein budding is reduced. Data further point out that the budding is from endoplasm reticulum of the sterol treated cells. author: Brown, Michael S., Goldstein, Joseph L., Nohturfft, Axel, Yabe, Daisuke, Espenshade, Peter J. Publisher: Elsevier B.V. Japan, Analysis, Endoplasmic reticulum, Metabolic regulation User Contributions: Comment about this article or add new information about this topic: Comment: (50-4000 characters) Name: E-mail: Security Code: Display my email: Article Abstract: Sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP) has been found to be necessary for increased lipid synthesis in liver brought on by cholesterol deprivation and insulin elevation. The SCAP gene was targeted by flanking exon1 with loxP sites, targets for bacteriophage P1Cre recombinase. Mice homozygous for the loxP-tagged SCAP allele were generated. They carry a transgene encoding Cre under control of the interferon-inducible MX1 promoter. The mice have a major lowering in synthesis of cholesterol and fatty acids. They do not have normal increase in the processes in response to insulin or to cholesterol deprivation.

31. Joseph L. Goldstein (Joseph L. Goldstein Kimdir? - Joseph L. Goldstein Hakkýnda)
    Joseph L. Goldstein MsXLabs.org Joseph L. Goldstein.jpg Joseph L. Goldstein (d. 18 Nisan 1940) Kingstree, G ney Karolina Nobel d l kazanmış bir biyokimyacı ve  
    http://www.msxlabs.org/forum/bilim-ww/236556-joseph-l-goldstein-joseph-l-goldste

32. Abolish The Insanity Defense-Why Not?1 : The Journal Of Nervous And Mental Disea
    Abolish the Insanity DefenseWhy Not?1 KATZ, JAY M.D.; GOLDSTEIN, JOSEPH L.L.B., PH.D.  
    http://journals.lww.com/jonmd/Abstract/1964/01000/Abolish_the_Insanity_Defense_W

33. University Of Texas Southwestern Medical Center At Dallas: Facts, Discussion For
    Start a new discussion about ' University of Texas Southwestern Medical Center at Dallas '  
    http://www.absoluteastronomy.com/topics/University_of_Texas_Southwestern_Medical
    
    Extractions: Home Discussion Topics Dictionary ... Login University of Texas Southwestern Medical Center at Dallas Discussion Ask a question about ' University of Texas Southwestern Medical Center at Dallas Start a new discussion about ' University of Texas Southwestern Medical Center at Dallas Answer questions from other users Full Discussion Forum Encyclopedia The University of Texas Southwestern Medical Center UT Southwestern or UTSW ) is one of the leading academic medical centers Medical Center A Medical Center is a concentration of medical care providers. The term can be used to refer to* A clinic* A hospital* A larger complex of medical facilities often including hospitals, research facilities, medical schools, and/or other health care facilities.Medical Center may also refer... in the world. It is the flagship biomedical research institution of the University of Texas System University of Texas System The University of Texas System comprises fifteen educational institutions in Texas, of which nine are for academy universities and six are health institutions. The UT System also offers online courses and degrees from UT institutions via the UT TeleCampus. The system is headquartered in Downtown... , incorporating three degree-granting institutions, four affiliated hospitals, including Parkland Memorial Parkland Memorial Hospital Parkland Memorial Hospital is a hospital located at 5201 Harry Hines Boulevard, just west of Oak Lawn in Dallas, Texas . It is the main hospital of the Dallas County Hospital District and serves as Dallas County's public hospital.- History :The original hospital opened in 1894 in a wooden...

34. DANGEROUSNESS AND MENTAL ILLNESS Some Observations On The De... : The Journal Of
    DANGEROUSNESS AND MENTAL ILLNESS Some Observations on the Decision to Release Persons Acquitted by Reason of Insanity KATZ, JAY M.D.; GOLDSTEIN, JOSEPH L.L.B., Ph.D.  
    http://journals.lww.com/jonmd/Citation/1960/11000/DANGEROUSNESS_AND_MENTAL_ILLNE

35. Sterol Regulatory Elements
    Brown, Michael S.; Goldstein, Joseph L.; Russell, David W.; Sudhof, Thomas C.; Disclosed are discrete functionally translocatable DNA segments, termed Sterol  
    http://www.devileye.net/catalog/gravity_flow_shelving_system/sterol_regulatory_e
    
    Extractions: The present invention relates to DNA segments which may be employed as functionally translocatable genetic control elements. More particularly, the invention relates to sterol regulatory elements and promoter sequences which serve to promote transcription and/or confer a sterol-mediated suppression capability to selected structural genes. In the 25 years since Jacob and Monod first proposed the lac operon model and the concept of messenger RNA (see, Jacob et al. (1961), J. Mol. Biol., 3: 318-350), the structure and function of a number of prokaryotic operons has been elucidated in elegant detail. For example, in the case of the lac operon, it has been shown that transcriptional control of the various structural genes of the operon (e.g., B-galactosidase) resides in an upstream (i.e., 5' with respect to the structural genes) regulator gene and operator gene. The regulator gene produces a protein "repressor" that interacts with the operator to prevent transcription initiation of the structural gene. Inducers such as IPTG (isopropyl thiogalactoside) bind to the repressor and thereby induce transcription by preventing the binding of the repressor to the operator. Additionally, there is a promoter site P, upstream of the operator and downstream of the regulatory gene, which serves as an RNA polymerase binding site.

36. Familial Hypercholesterolemia: Defective Binding Of Lipoproteins To Cultured Fib
    Brown Michael S, Dana Suzanna E, Goldstein Joseph L. Regulation of 3Hydroxy-3-Methylglutaryl Coenzyme A Reductase Activity in Human Fibroblasts by Lipoproteins.  
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC388099/
    
    Extractions: window.name="mainwindow"; initRedirectClicks('/pmc/extredirect/') Journal List Proc Natl Acad Sci U S A v.71(3); Mar 1974 Proc Natl Acad Sci U S A. 1974 March; PMCID: Familial Hypercholesterolemia: Defective Binding of Lipoproteins to Cultured Fibroblasts Associated with Impaired Regulation of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Activity Michael S. Brown and Joseph L. Goldstein Division of Gastroenterology-Liver, Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, Texas 75235 Division of Medical Genetics, Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, Texas 75235 This article has been cited by other articles in PMC. Abstract Monolayers of cultured fibroblasts from normal human subjects bind I-labeled low-density lipoproteins from the binding sites, but high-density lipoproteins, the lipoprotein-deficient fraction of serum, and abetalipoproteinemic serum did not. This binding appears to be a required step in the process by which low-density lipoproteins normally suppress the synthesis of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase, the rate-controlling enzyme in cholesterol biosynthesis. The demonstration of a defect in binding of low-density lipoproteins to cells from subjects with the homozygous form of familial hypercholesterolemia appears to explain the previously reported failure of lipoproteins to suppress the synthesis of this enzyme and hence may account for the overproduction of cholesterol that occurs in these cultured cells.

37. Joseph Goldstein - Research Profile On BiomedExperts
    2002 Goldstein Joseph L; Rawson Robert B; Brown Michael S Mutant mammalian cells as tools to delineate the sterol regulatory elementbinding protein pathway for feedback regulation  
    http://www.biomedexperts.com/Profile.bme/474938/Joseph_L_Goldstein

38. Joseph Goldstein - Wikipédia, A Enciclopédia Livre
    Rpt Per GOLDSTEIN JOSEPH L EDGAR is a federally registered trademark of the U.S. Securities and Exchange  
    http://pt.wikipedia.org/wiki/Joseph_L._Goldstein
    
    Extractions: Kingstree Nacionalidade Estadunidense Campo(s) Medicina Prêmio(s) Prêmio Albert Lasker de Pesquisa Médica Básica (1985) Nobel de Fisiologia/Medicina (1985) Joseph Leonard Goldstein Kingstree 18 de Abril de ) é um médico geneticista molecular estadunidense Foi agraciado com o Nobel de Fisiologia/Medicina de , por descobertas relativas ao metabolismo do colesterol v e Nobel de Fisiologia ou Medicina (1976 — 2000) ... Baruch Blumberg e Daniel Gajdusek Roger Guillemin Andrzej Schally e Rosalyn Yalow Werner Arber Daniel Nathans e Hamilton Smith Allan Cormack e Godfrey Hounsfield Baruj Benacerraf Jean Dausset e George Snell Roger Sperry David Hubel e Torsten Wiesel Sune Bergström Bengt Samuelsson e John Vane Barbara McClintock Niels Jerne Georges Köhler e César Milstein Michael Stuart Brown e Joseph Goldstein Stanley Cohen e Rita Levi-Montalcini Susumu Tonegawa James Black Gertrude Elion e George Hitchings John Michael Bishop e Harold Varmus Joseph Murray e Edward Donnall Thomas Erwin Neher e Bert Sakmann Edmond Fischer e Edwin Krebs Richard Roberts e Phillip Sharp Alfred Gilman e Martin Rodbell Edward Lewis Christiane Nüsslein-Volhard e

39. Abstracts: How A Jolt And A Bolt In A DentistEs Chair Revolutionized Cataract Su
    author Goldstein, Joseph L. Publisher Nature America, Inc. Publication Name Nature Medicine Subject Health  
    http://www.faqs.org/abstracts/Health/How-a-jolt-and-a-bolt-in-a-dentistEs-chair-
    
    Extractions: Faqs.org homepage Abstracts index Health Article Abstract: The author discusses this year Lasker Awards that honor the development of two technologies. The technology that allows the scientists to manipulate the mouse genome with exquisite precision and the technology that has revolutionalized the treatment of human infertility have been honored. author: Goldstein, Joseph L. Publisher: Nature America, Inc. Recombinant DNA, Genomes, Infertility User Contributions: Comment about this article or add new information about this topic: Comment: (50-4000 characters) Name: E-mail: Security Code: Display my email: Article Abstract: Cataracts were the leading cause of blindness in the United States until 1970, but today in the United States and many other countries, cataracts no longer hold a significant cause of blindness. A major credit for this goes to Charles D. Kelman, who has received considerable recognition for his legendary contributions to medicine, including every major award in fields of ophthalmology and cataract surgery. author: Goldstein, Joseph L.

40. REGN Insider Trading Transactions, Insider Planned Sales - MSN Money
    GOLDSTEIN JOSEPH L Sold 400 $28.06 11,224.00 05/14/10 GOLDSTEIN JOSEPH L Exercise 5,000 $25.43 127,150.00 05/14/10 VAGELOS P ROY Sold 20,000 $27.08 541,500.00  
    http://moneycentral.msn.com/investor/invsub/insider/trans.asp?Symbol=REGN

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