Prions Title Prions Authors Prusiner, Stanley B. Publication Proceedings of the National Academy of Sciences of the United States of America, Volume 95, Issue 23, pp. 1336313383 http://adsabs.harvard.edu/abs/1998PNAS...9513363P
Extractions: JSTOR Bibliographic Code: Abstract Prions are unprecedented infectious pathogens that cause a group of invariably fatal neurodegenerative diseases by an entirely novel mechanism. Prion diseases may present as genetic, infectious, or sporadic disorders, all of which involve modification of the prion protein (PrP). Bovine spongiform encephalopathy (BSE), scrapie of sheep, and Creutzfeldt-Jakob disease (CJD) of humans are among the most notable prion diseases. Prions are transmissible particles that are devoid of nucleic acid and seem to be composed exclusively of a modified protein (PrP Sc ). The normal, cellular PrP (PrP
Molecular Biology And Genetics Of Prion Diseases Title Molecular Biology and Genetics of Prion Diseases Authors Prusiner, Stanley B. Publication Philosophical Transactions Biological Sciences, Volume 343, Issue 1306, pp http://adsabs.harvard.edu/abs/1994RSPTB.343..447P
Extractions: JSTOR Bibliographic Code: Abstract Sc and PrP C suggest that the difference is conformational. Whether one or more putative alpha -helices in PrP C are converted into beta -sheets during synthesis of PrP Sc is unknown. Distinct prion isolates or `strains' exhibit different patterns of PrP Sc accumulation which are independent of incubation times. Whether variations in PrP Sc conformation are responsible for prion diversity remains to be established. Prion studies have given new insights into the etiologies of infectious, sporadic and inherited degenerative diseases. Bibtex entry for this abstract Preferred format for this abstract (see Preferences Use: Authors Title Abstract Text Return: Query Results Return items starting with number Query Form Database: Astronomy Physics arXiv e-prints
Extractions: OR This volume is a new edition of the most authoritative book on Prion Biology, first published in 1999 and edited by the Nobel Prize-winning founder of the field. This expanded edition has been completely updated, and includes chapters on therapeutics, and diagnostic methods and approaches. top Details of Book: Prion Biology And Diseases-2nd Ed-#41 Book: Prion Biology And Diseases-2nd Ed-#41 Related Tags prion biology and diseases stanley b prusiner contact stanley prusiner prion biology and diseases by stanley b prusiner prion biology and diseases second edition stanley b prusiner prion biology diseases by prusiner diseases spring harbor 2nd stanley prusiner 2009 stanley b prusiner y los priones
Models Of Prion Disease Prusiner, Stanley B.; Korth, Carsten; The present invention provides a novel PrP protein, and nucleic acids encoding http://www.devileye.net/catalog/slotting_cutter/models_prion_disease.html
Extractions: Prusiner, Stanley B.; Korth, Carsten; The present invention provides a novel PrP protein, and nucleic acids encoding this protein, where the PrP protein is characterized in vivo by 1) incomplete glycosylation relative to glycosylation of wild-type PrP.sup.C and 2) proper cellular localization, i.e. an ability to be transported to the cell surface. This novel, under-glycosylated PrP, unlike its normal cellular counterpart, can easily be converted into a protease-resistant isoform by incubation with infectious prions. The invention further provides systems for the study of prion disorders and methods of using these systems, e.g. the study of the mechanical processes in progression of prion-mediated disease or the identification of new therapeutic agents for treatment of prion-mediated disorders. In such systems, protease-resistant under-glycosylated PrP is generated de novo and can be detected by standard immunoblot techniques. FIELD OF THE INVENTION Prions are infectious pathogens that cause central nervous system spongiform encephalopathies in humans and animals. Prions are distinct from bacteria, viruses and viroids. The predominant hypothesis at present is that no nucleic acid component is necessary for infectivity of prion protein. Further, a prion which infects one species of animal (e.g., a human) will not readily infect another (e.g., a mouse).
Method Of Sterilizing Prusiner, Stanley B.; Supattapone, Surachai; Scott, Michael R.; A method of sterilizing objects as well as the sterilized objects obtained from http://www.devileye.net/catalog/toner/sterilizing.html
Extractions: Prusiner, Stanley B.; Supattapone, Surachai; Scott, Michael R.; A method of sterilizing objects as well as the sterilized objects obtained from the method are disclosed. The method involves contacting an object such as a medical device to be reused with polycationic dendrimer under conditions which result in rendering a conformationally altered protein (e.g. a prion) non-infectious. A disinfecting agent or surgical scrub composition which comprises the dendrimers is also disclosed as are gelatin capsules treated with polycationic dendrimers. FIELD OF THE INVENTION There are large numbers of known methods of sterilizing materials. Many methods involve heating a material to a temperature at which pathogens are killed or inactivated. Other methods involve exposing the material to compounds which kill or inactivate pathogens which are contacted by the compounds. Still other methods involve irradiating a material with a sufficient amount of a particular type of radiation for a period of time sufficient to inactivate, disrupt or kill pathogens in the material. These methods are generally directed toward killing bacteria and inactivating viruses present in or on the material. Although sterilization methods may be quite affective in killing bacteria or inactivating viruses, they do not generally inactivate pathogenic proteins such as prions which can be responsible for a number of fatal diseases.
Prusiner, Stanley B. - Personenlexikon CreutzfeldtJakob Disease and Scrapie Prions PRUSINER, STANLEY B. M.D. Creutzfeldt-Jakob disease, kuru, and Gerstmann-Straussler syndrome are http://www.personenlexikon.net/d/prusiner-stanley-b/prusiner-stanley-b.htm
Extractions: Startseite Personenlexikon Thematische Gliederung Gruppen Kategorien ... Z amerikanischer Mediziner, Neurologe und Biochemiker, geboren 28.5.1942 Des Moines, Iowa; seit 1984 Professor fr Neurologie an der University of California in San Francisco und Gastprofessor fr Virologie in Berkeley, zudem seit 1988 Professor fr Biochemie in San Francisco; entdeckte die Prion-Proteine und konnte mutierte Prion-Proteine als verursachendes Agens fr die Entstehung hirnzerstrender Krankheiten wie Bovine Spongiforme Encephalopathie (BSE, Rinderwahnsinn), CreutzfelJako- -Erkrankung, Kuru und Scrapie nachweisen; die Annahme, da Prion-Proteine keine DNA enthalten, widerspricht dem bisherigen Dogma, nach dem sich infektise Erreger nicht ohne genetisches Material (DNA/RNA) vermehren knnen; erhielt 1997 den Nobelpreis fr Physiologie oder Medizin. Diese Seite als Bookmark speichern : addthis_url = location.href; addthis_title = document.title; addthis_pub = 'woorgle1492'; Prout, William
What's All The Fuss About Prion Diseases? Prusiner, Stanley B. The Prion Diseases in Scientific American, Vol. 272, No. 1, January 1995. Prusiner, Stanley B. Detecting Mad Cow Disease in Scientific American, Vol. 291 http://www.northfortynews.com/Archive/A200411Prions.htm
Extractions: Correspondent Human nervous system diseases caused by minute protein fragments called prions (pronounced "pree-ons") include Creutzfeldt-Jakob disease, kuru, Gerstmann-Straussler-Scheinker disease and fatal familial insomnia. Yes, they are incurably fatal, and yes, families must watch loved ones die slowly with a gradual loss of mental function, but only a few hundred cases have been documented worldwide. Contrast that to flu epidemics that can take millions of lives at a time. Why get unduly worried about rare transmissions of prions between species, as with the "mad cow" epidemic or recent concerns about chronic wasting disease (CWD) in deer and elk? Why pour money into research on "one-in-a-million" diseases? The answer to the first question is easy: Prion diseases are scary. The answer to the second is uniquely human: Prion diseases are weird and we want to know why. Curiosity has been a fruitful human ally in the past. Prion diseases challenge what we think we know about biology.
Stanley B. Prusiner Stanley B. Prusiner . Stanley B. Prusiner. Stanley B. Prusiner AKA Stanley Benjamin Prusiner. Born 28 May-1942 NNDB MAPPER, Create a map starting with, Stanley B. Prusiner http://www.kosmix.com/topic/Stanley_B._Prusiner
Extractions: Kosmix One sec... we're building your guide for Stanley B. Prusiner document.k_start_apptier = "Nov 01 01:40:28.615711"; kapp.assignCol($('ads_banner_top'), 'topnav_container'); kapp.nav_menu_container = $('refine_nav').down(".navs_container"); kapp.assignCol($('refine_nav'), 'topnav_container'); kapp.assignCol($('uc_kosmixarticles_shadow'), 'right_container'); Video Search from Truveo From: Nobel Prize kapp.mCallback($('video_trv')); More Video from Truveo kapp.assignCol($('video'), 'left_container'); Kosmix Meir Wilchek (Hebrew: מאיר אשר וילצ'ק, born in 1935) is an Israeli biochemist. He is a professor at ... Roger Yonchien Tsien (; born February 1, 1952) is an American biochemist and a professor at the Department of Chemistry and Biochemistry ... Mario Renato Capecchi (born 6 October 1937) is an Italian-born American molecular geneticist and a co-winner of the 2007 Nobel ... Oliver Smithies (born June 23, 1925) is a British-born American geneticist and Nobel laureate, credited with the invention of ...
Scientific Commons Doppel-induced Cerebellar Degeneration In Prusiner, Stanley B., Hood, Leroy, Westaway, David, DeArmond, Stephen J., Tremblay, Patrick; Abstract Doppel (Dpl) is a paralog of the mammalian prion protein (PrP); it is abundant in http://en.scientificcommons.org/11570023
Edge: STANLEY B. PRUSINER Stanley B. Prusiner. STANLEY B. PRUSINER M.D., is Director of the Institute for Neurodegenerative Diseases and Professor of Neurology and Biochemistry at the University of California http://www.edge.org/3rd_culture/bios/prusiner.html
Extractions: Home About Edge Features Edge Editions ... Search Stanley B. Prusiner STANLEY B. PRUSINER M.D., is Director of the Institute for Neurodegenerative Diseases and Professor of Neurology and Biochemistry at the University of California, San Francisco. In 1997 he was awarded the Nobel Prize in Physiology or medicine for his discovery of prions, a new class of pathogens that replicate without nucleic acid. Through this work, he created a new field of research that has resulted in significant progress in understanding degenerative diseases of the central nervous system (CNS). Beyond Edge
Stanley Prusiner - Research Profile On BiomedExperts 2003 Ryou Chongsuk; Prusiner Stanley B; Legname Giuseppe Cooperative binding of dominantnegative prion protein to kringle domains. Journal of molecular biology 2003;329(2)323-33. http://www.biomedexperts.com/Profile.bme/1142898/Stanley_B_Prusiner
Stanley Prusiner - Wikipédia, A Enciclopédia Livre Prusiner, Stanley B., Cohen, Fred E. Abstract Recent progress determining the structure of the hostencoded prion protein (PrPC) and the role of auxiliary molecules in prion http://pt.wikipedia.org/wiki/Stanley_B._Prusiner
Extractions: v e Prêmio Wolf de Medicina (1978 — 2008) ... Leo Sachs , Sir James L. Gowans Barbara McClintock Stanley N. Cohen Jean-Pierre Changeux ... Yasutomi Nishizuka Stanley Prusiner Mary Frances Lyon Michael Sela Ruth Arnon Eric Kandel ... Baruch Blumberg e Daniel Gajdusek Roger Guillemin Andrzej Schally e Rosalyn Yalow Werner Arber Daniel Nathans e Hamilton Smith Allan Cormack e Godfrey Hounsfield Baruj Benacerraf Jean Dausset e George Snell Roger Sperry David Hubel e Torsten Wiesel Sune Bergström Bengt Samuelsson e John Vane Barbara McClintock Niels Jerne Georges Köhler e César Milstein Michael Stuart Brown e Joseph Goldstein Stanley Cohen e Rita Levi-Montalcini Susumu Tonegawa James Black Gertrude Elion e George Hitchings John Michael Bishop e Harold Varmus Joseph Murray e Edward Donnall Thomas Erwin Neher e Bert Sakmann Edmond Fischer e Edwin Krebs Richard Roberts e Phillip Sharp Alfred Gilman e Martin Rodbell Edward Lewis Christiane Nüsslein-Volhard e
Giuseppe Baldwin - WikiName Ilia Baskakov research profile on BiomedExperts 2004 Baskakov Ilia V; Legname Giuseppe; Gryczynski Zygmunt; Prusiner Stanley B 2002 Baskakov Ilia V; Legname Giuseppe; Baldwin http://wiki.name.com/en/Giuseppe_Baldwin
Extractions: BALD-win, BALD-wen Register Giuseppe Baldwin as a domain Stanley Prusiner - research profile on BiomedExperts 2009: Bae Sung-Hun; Legname Giuseppe ; Serban Ana; Prusiner Stanley B; Wright Peter E; 2002: Baskakov Ilia V; Legname Giuseppe Baldwin Michael A; Prusiner Stanley B; Cohen Copper induces increased beta-sheet content in the scrapie Stahl N, Baldwin MA, Teplow DB, Hood L, Gibson BW, Burlingame AL, Prusiner SB. Baskakov Ilia V, Legname Giuseppe Baldwin Michael A, Prusiner Stanley B, Cohen Fred Cohen - research profile on BiomedExperts Fred Cohen - research profile on BiomedExperts:Protein Conformation, Prions, Molecular Models, Amino Acid Sequence, Secondary Protein Structure, Molecular Sequence Data. MySpace - HAHAHAAAAA - 29 - Female - - myspace.com/cennateree MySpace profile for HAHAHAAAAA with pictures, videos, personal blog, interests, information about me and more Journal of Biological Chemistry, 2002; 277 (24)
Prion Prusiner, Stanley B. American neurologist (1942) and winner of the Nobel Prize for the discovery of prions - a new biological principle of infection. http://health-search.closerlooksearch.com/health-topics/P/prion.html
Extractions: window.name="mainwindow"; initRedirectClicks('/pmc/extredirect/') Journal List Protein Sci v.9(2); Feb 2000 Protein Sci. 2000 February; PMCID: Copper binding to octarepeat peptides of the prion protein monitored by mass spectrometry. R. M. Whittal, H. L. Ball, F. E. Cohen, A. L. Burlingame, S. B. Prusiner, and M. A. Baldwin Department of Pharmaceutical Chemistry, University of California San Francisco, 94143-0446, USA. This article has been cited by other articles in PMC. Abstract Full Text The Full Text of this article is available as a PDF Selected References These references are in PubMed. This may not be the complete list of references from this article. Anderson RG, Kamen BA, Rothberg KG, Lacey SW. Potocytosis: sequestration and transport of small molecules by caveolae. Science. 1992 Jan 24; PubMed Atwood CS, Moir RD, Huang X, Scarpa RC, Bacarra NM, Romano DM, Hartshorn MA, Tanzi RE, Bush AI. Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis. J Biol Chem.
Extractions: GO TO ADVANCED SEARCH LOGIN: Removal of prions from blood, plasma and other liquids United States Patent Application 20010005578 Kind Code: Devices such as flow through columns, substrates such as spherical polymer beads, and methods of using such to remove prions from any liquid sample are disclosed. A surface of a substrate is coated with a prion complexing agent, such as a salt of phosphotungstic acid. Blood or plasma passing through a column containing beads coated with prion complexing agent are rendered prion free. Related US Applications: Flow-through assay devices Yang et al. - June, 2005 - 20050136500 COMPOSITON FOR NON-TOXIC, NON-HAZARDOUS, AND ENVIRONMENTALLY FRIENDLY HUMIDITY-INDICATING AGENT AND ITS APPLICATION Song et al. - May, 2005 - 20050106735 PLATELET RICH PLASMA FORMULATIONS FOR CARDIAC TREATMENTS Mishra - April, 2010 - 20100092444 Diagnostic assay system Ray - May, 2002 - 20020055176 Device for Collecting Blood and Separating Blood Constituents, Method for Separating Blood Constituents and Use of Said Device Blankenstein et al. - November, 2007 - 20070269893
Nobel Laureates - List Prusiner, Stanley B. San Francisco 1997 Physiology or medicine Reines, Frederick* Irvine 1995 Physics Rose, Irwin Irvine 2004 Chemistry Rowland, F. Sherwood http://www.universityofcalifornia.edu/nobel/list.html
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